Search Results - "Mourão, André Santos Dias"

Phase separation of FSP1 promotes ferroptosis by Nakamura, Toshitaka, Hipp, Clara, Santos Dias Mourão, André, Borggräfe, Jan, Aldrovandi, Maceler, Henkelmann, Bernhard, Wanninger, Jonas, Mishima, Eikan, Lytton, Elena, Emler, David, Proneth, Bettina, Sattler, Michael, Conrad, Marcus

“…Ferroptosis is evolving as a highly promising approach to combat difficult-to-treat tumour entities including therapy-refractory and dedifferentiating cancers…”
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A non-canonical vitamin K cycle is a potent ferroptosis suppressor by Mishima, Eikan, Ito, Junya, Wu, Zijun, Nakamura, Toshitaka, Wahida, Adam, Doll, Sebastian, Tonnus, Wulf, Nepachalovich, Palina, Eggenhofer, Elke, Aldrovandi, Maceler, Henkelmann, Bernhard, Yamada, Ken-ichi, Wanninger, Jonas, Zilka, Omkar, Sato, Emiko, Feederle, Regina, Hass, Daniela, Maida, Adriano, Mourão, André Santos Dias, Linkermann, Andreas, Geissler, Edward K., Nakagawa, Kiyotaka, Abe, Takaaki, Fedorova, Maria, Proneth, Bettina, Pratt, Derek A., Conrad, Marcus

“…Ferroptosis, a non-apoptotic form of cell death marked by iron-dependent lipid peroxidation 1 , has a key role in organ injury, degenerative disease and…”
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DHODH inhibitors sensitize to ferroptosis by FSP1 inhibition by Mishima, Eikan, Nakamura, Toshitaka, Zheng, Jiashuo, Zhang, Weijia, Mourão, André Santos Dias, Sennhenn, Peter, Conrad, Marcus

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Integrated chemical and genetic screens unveil FSP1 mechanisms of ferroptosis regulation by Nakamura, Toshitaka, Mishima, Eikan, Yamada, Naoya, Mourão, André Santos Dias, Trümbach, Dietrich, Doll, Sebastian, Wanninger, Jonas, Lytton, Elena, Sennhenn, Peter, Nishida Xavier da Silva, Thamara, Angeli, José Pedro Friedmann, Sattler, Michael, Proneth, Bettina, Conrad, Marcus

“…Ferroptosis, marked by iron-dependent lipid peroxidation, may present an Achilles heel for the treatment of cancers. Ferroptosis suppressor protein-1 (FSP1),…”
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MISATO: machine learning dataset of protein-ligand complexes for structure-based drug discovery by Siebenmorgen, Till, Menezes, Filipe, Benassou, Sabrina, Merdivan, Erinc, Didi, Kieran, Mourão, André Santos Dias, Kitel, Radosław, Liò, Pietro, Kesselheim, Stefan, Piraud, Marie, Theis, Fabian J, Sattler, Michael, Popowicz, Grzegorz M

“…Large language models have greatly enhanced our ability to understand biology and chemistry, yet robust methods for structure-based drug discovery, quantum…”
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DHODH inhibitors sensitize to ferroptosis by FSP1 inhibition/Reply by Mishima, Eikan, Nakamura, Toshitaka, Zheng, Jiashuo, Zhang, Weijia, Mourão, André Santos Dias, Sennhenn, Peter, Conrad, Marcus, Mao, Chao, Liu, Xiaoguang, Yan, Yuelong, Olszewski, Kellen, Gan1, Boyi

“…The observed effects on ferroptosis sensitization with this concentration of inhibitors cannot be attributed to DHODH inhibition per se. [...]applying…”
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A tangible method to assess native ferroptosis suppressor activity by Nakamura, Toshitaka, Ito, Junya, Mourão, André Santos Dias, Wahida, Adam, Nakagawa, Kiyotaka, Mishima, Eikan, Conrad, Marcus

“…Ferroptosis, a regulated cell death hallmarked by unrestrained lipid peroxidation, plays a pivotal role in the pathophysiology of various diseases, making it a…”
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