Search Results - "Mouneimne, G."

Lamellipodin promotes invasive 3D cancer cell migration via regulated interactions with Ena/VASP and SCAR/WAVE by Carmona, G, Perera, U, Gillett, C, Naba, A, Law, A-L, Sharma, V P, Wang, J, Wyckoff, J, Balsamo, M, Mosis, F, De Piano, M, Monypenny, J, Woodman, N, McConnell, R E, Mouneimne, G, Van Hemelrijck, M, Cao, Y, Condeelis, J, Hynes, R O, Gertler, F B, Krause, M

“…Cancer invasion is a hallmark of metastasis. The mesenchymal mode of cancer cell invasion is mediated by elongated membrane protrusions driven by the assembly…”
Get full text

Effect of suberoylanilide hydroxamic acid (SAHA) on breast cancer cells within a tumor-stroma microfluidic model by Peela, N, Barrientos, E S, Truong, D, Mouneimne, G, Nikkhah, M

“…Metastatic cancer is regarded as one of the largest contributors to disease-related deaths worldwide. Poor patient prognosis and treatment outcome is tied to…”
Get full text

The effect of endotoxin on functional parameters of mammary CID-9 cells by Safieh-Garabedian, B, Mouneimne, G M, El-Jouni, W, Khattar, M, Talhouk, R

“…The effect of endotoxin on mammary CID-9 cells, which differentiate in culture and express β-casein, was investigated. Cells in culture supplemented with…”
Get full text

Functional interplay between gelatinases and hyperalgesia in endotoxin-induced localized inflammatory pain by Talhouk, R S, Hajjar, L, Abou-Gergi, R, Simaa'n, C J, Mouneimne, G, Saade', N E, Safieh-Garabedian, B

“…The role of ECM-degrading proteinases in normal developmental processes and in pathological conditions is extensively studied. However, few reports describe…”
Get full text

Cofilin Promotes Actin Polymerization and Defines the Direction of Cell Motility by Ghosh, Mousumi, Song, Xiaoyan, Mouneimne, Ghassan, Sidani, Mazen, Lawrence, David S., Condeelis, John S.

“…A general caging method for proteins that are regulated by phosphorylation was used to study the in vivo biochemical action of cofilin and the subsequent…”
Get full text

activity status of cofilin is directly related to invasion, intravasation, and metastasis of mammary tumors by Wang, Weigang, Mouneimne, Ghassan, Sidani, Mazen, Wyckoff, Jeffrey, Chen, Xiaoming, Makris, Anastasia, Goswami, Sumanta, Bresnick, Anne R, Condeelis, John S

“…Understanding the mechanisms controlling cancer cell invasion and metastasis constitutes a fundamental step in setting new strategies for diagnosis, prognosis,…”
Get full text

Effect of suberoylanilide hydroxamic acid (SAHA) on breast cancer cells within a tumor-stroma microfluidic modelElectronic supplementary information (ESI) available. See DOI: 10.1039/c7ib00180k by Peela, N, Barrientos, E. S, Truong, D, Mouneimne, G, Nikkhah, M

“…Metastatic cancer is regarded as one of the largest contributors to disease-related deaths worldwide. Poor patient prognosis and treatment outcome is tied to…”
Get full text

Spatial and Temporal Control of Cofilin Activity Is Required for Directional Sensing during Chemotaxis by Mouneimne, Ghassan, DesMarais, Vera, Sidani, Mazen, Scemes, Eliana, Wang, Weigang, Song, Xiaoyan, Eddy, Robert, Condeelis, John

“…Previous work has led to the hypothesis that cofilin severing, as regulated by PLC, is involved in chemotactic sensing. We have tested this hypothesis by…”
Get full text

Phospholipase C and Cofilin Are Required for Carcinoma Cell Directionality in Response to EGF Stimulation by Mouneimne, Ghassan, Soon, Lilian, DesMarais, Vera, Sidani, Mazen, Song, Xiaoyan, Yip, Shu-Chin, Ghosh, Mousumi, Eddy, Robert, Backer, Jonathan M., Condeelis, John

“…The epidermal growth factor (EGF)-induced increase in free barbed ends, resulting in actin polymerization at the leading edge of the lamellipodium in carcinoma…”
Get full text

Cellular localization of activated N-WASP using a conformation-sensitive antibody by Sukumvanich, P., DesMarais, V., Sarmiento, C.V., Wang, Y., Ichetovkin, I., Mouneimne, G., Almo, S., Condeelis, J.

“…The main regulators of Arp2/3 activity appear to be N‐WASP and the other members of the Scar/WAVE family of proteins. We show here that after EGF stimulation,…”
Get full text

Growth hormone releasing hormone reverses endotoxin-induced localized inflammatory hyperalgesia without reducing the upregulated cytokines, nerve growth factor and gelatinase activity by Talhouk, Rabih S., Saadé, Nayef E., Mouneimne, Ghassan, Masaad, Cynthia A., Safieh-Garabedian, Bared

“…During inflammatory processes, the hypothalamic-pituitary axis is activated which can subsequently result in analgesia. For example, hypothalamic…”
Get full text

Description and characterization of a chamber for viewing and quantifying cancer cell chemotaxis by Soon, Lilian, Mouneimne, Ghassan, Segall, Jeffrey, Wyckoff, Jeffrey, Condeelis, John

“…Direct observations of cancer cell invasion underscore the importance of chemotaxis in invasion and metastasis. Yet, there is to date, no established method…”
Get full text