Search Results - "Moulding, Dale A."

The cytoplasm of living cells behaves as a poroelastic material by Moeendarbary, Emad, Valon, Léo, Fritzsche, Marco, Harris, Andrew R., Moulding, Dale A., Thrasher, Adrian J., Stride, Eleanor, Mahadevan, L., Charras, Guillaume T.

“…The cytoplasm is the largest part of the cell by volume and hence its rheology sets the rate at which cellular shape changes can occur. Recent experimental…”
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Dynamics and consequences of the HTLV-1 proviral plus-strand burst by Ramanayake, Saumya, Moulding, Dale A, Tanaka, Yuetsu, Singh, Abhyudai, Bangham, Charles R M

“…Expression of the transcriptional transactivator protein Tax, encoded on the proviral plus-strand of human T-cell leukaemia virus type 1 (HTLV-1), is crucial…”
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Systemic gene therapy with thymosin β4 alleviates glomerular injury in mice by Mason, William J., Jafree, Daniyal J., Pomeranz, Gideon, Kolatsi-Joannou, Maria, Rottner, Antje K., Pacheco, Sabrina, Moulding, Dale A., Wolf, Anja, Kupatt, Christian, Peppiatt-Wildman, Claire, Papakrivopoulou, Eugenia, Riley, Paul R., Long, David A., Vasilopoulou, Elisavet

“…Plasma ultrafiltration in the kidney occurs across glomerular capillaries, which are surrounded by epithelial cells called podocytes. Podocytes have a unique…”
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Molecular control of neutrophil apoptosis by Akgul, Cahit, Moulding, Dale A, Edwards, Steven W

“…Human neutrophils constitutively undergo apoptosis and this process is critical for the resolution of inflammation. Whilst neutrophil apoptosis can be…”
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Overexpression of Fgfr2c causes craniofacial bone hypoplasia and ameliorates craniosynostosis in the Crouzon mouse by Lee, Kevin K L, Peskett, Emma, Quinn, Charlotte M, Aiello, Rosanna, Adeeva, Liliya, Moulding, Dale A, Stanier, Philip, Pauws, Erwin

“…FGFR2c regulates many aspects of craniofacial and skeletal development. Mutations in the gene are causative of multiple forms of syndromic craniosynostosis,…”
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Unregulated actin polymerization by WASp causes defects of mitosis and cytokinesis in X-linked neutropenia by Moulding, Dale A, Blundell, Michael P, Spiller, David G, White, Michael R H, Cory, Giles O, Calle, Yolanda, Kempski, Helena, Sinclair, Jo, Ancliff, Phil J, Kinnon, Christine, Jones, Gareth E, Thrasher, Adrian J

“…Specific mutations in the human gene encoding the Wiskott-Aldrich syndrome protein (WASp) that compromise normal auto-inhibition of WASp result in unregulated…”
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The Mitochondrial Network of Human Neutrophils: Role in Chemotaxis, Phagocytosis, Respiratory Burst Activation, and Commitment to Apoptosis by Fossati, Gianluca, Moulding, Dale A, Spiller, David G, Moots, Robert J, White, Michael R. H, Edwards, Steven W

“…It is commonly assumed that human neutrophils possess few, if any, functional mitochondria and that they do not depend on these organelles for cell function…”
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BCL-2 family expression in human neutrophils during delayed and accelerated apoptosis by Moulding, Dale A., Akgul, Cahit, Derouet, Mathieu, White, Michael R. H., Edwards, Steven W.

“…The human neutrophil spontaneously undergoes apoptosis, but this type of cell death can be delayed or accelerated by a wide variety of agents. There are wide…”
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The timing of auditory sensory deficits in Norrie disease has implications for therapeutic intervention by Bryant, Dale, Pauzuolyte, Valda, Ingham, Neil J, Patel, Aara, Pagarkar, Waheeda, Anderson, Lucy A, Smith, Katie E, Moulding, Dale A, Leong, Yeh C, Jafree, Daniyal J, Long, David A, Al-Yassin, Amina, Steel, Karen P, Jagger, Daniel J, Forge, Andrew, Berger, Wolfgang, Sowden, Jane C, Bitner-Glindzicz, Maria

“…Norrie disease is caused by mutation of the NDP gene, presenting as congenital blindness followed by later onset of hearing loss. Protecting patients from…”
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Actin cytoskeletal defects in immunodeficiency by Moulding, Dale A., Record, Julien, Malinova, Dessislava, Thrasher, Adrian J.

“…Summary The importance of the cytoskeleton in mounting a successful immune response is evident from the wide range of defects that occur in actin‐related…”
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Phosphorylation of WASp is a key regulator of activity and stability in vivo by Blundell, Michael P, Bouma, Gerben, Metelo, Joao, Worth, Austen, Calle, Yolanda, Cowell, Lucy A, Westerberg, Lisa S, Moulding, Dale A, Mirando, Samuel, Kinnon, Christine, Cory, Giles O, Jones, Gareth E, Snapper, Scott B, Burns, Siobhan O, Thrasher, Adrian J

“…The Wiskott-Aldrich syndrome protein (WASp) is a key cytoskeletal regulator in hematopoietic cells. Covalent modification of a conserved tyrosine by…”
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Quantifying mechanical forces during vertebrate morphogenesis by Maniou, Eirini, Todros, Silvia, Urciuolo, Anna, Moulding, Dale A., Magnussen, Michael, Ampartzidis, Ioakeim, Brandolino, Luca, Bellet, Pietro, Giomo, Monica, Pavan, Piero G., Galea, Gabriel L., Elvassore, Nicola

“…Morphogenesis requires embryonic cells to generate forces and perform mechanical work to shape their tissues. Incorrect functioning of these force fields can…”
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Continuous MLL-ENL expression is necessary to establish a hox code and maintain immortalization of hematopoietic progenitor cells by HORTON, Sarah J, GRIER, David G, WILLIAMS, Owen, MCGONIGLE, Glenda J, THOMPSON, Alexander, MORROW, Michelle, DE SILVA, Inusha, MOULDING, Dale A, KIOUSSIS, Dimitris, LAPPIN, Terence R. J, BRADY, Hugh J. M

“…The t[(11;19)(p22;q23)] translocation, which gives rise to the MLL-ENL fusion protein, is commonly found in infant acute leukemias of both the myeloid and…”
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Somatic mutations and progressive monosomy modify SAMD9-related phenotypes in humans by Buonocore, Federica, Kühnen, Peter, Suntharalingham, Jenifer P, Del Valle, Ignacio, Digweed, Martin, Stachelscheid, Harald, Khajavi, Noushafarin, Didi, Mohammed, Brady, Angela F, Blankenstein, Oliver, Procter, Annie M, Dimitri, Paul, Wales, Jerry K H, Ghirri, Paolo, Knöbl, Dieter, Strahm, Brigitte, Erlacher, Miriam, Wlodarski, Marcin W, Chen, Wei, Kokai, George K, Anderson, Glenn, Morrogh, Deborah, Moulding, Dale A, McKee, Shane A, Niemeyer, Charlotte M, Grüters, Annette, Achermann, John C

“…It is well established that somatic genomic changes can influence phenotypes in cancer, but the role of adaptive changes in developmental disorders is less…”
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Identifying cellular signalling molecules in developmental disorders of the brain: Evidence from focal cortical dysplasia and tuberous sclerosis by Li, Yao‐Feng, Scerif, Fatma, Picker, Simon R., Stone, Thomas J., Pickles, Jessica C., Moulding, Dale A., Avery, Aimee, Virasami, Alex, Fairchild, Amy R., Tisdall, Martin, Harkness, William, Cross, J Helen, Hargrave, Darren, Guillemot, Francois, Paine, Simon M., Yasin, Shireena A., Jacques, Thomas S.

“…Aims We understand little of the pathogenesis of developmental cortical lesions, because we understand little of the diversity of the cell types that…”
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Excess F-actin mechanically impedes mitosis leading to cytokinesis failure in X-linked neutropenia by exceeding Aurora B kinase error correction capacity by Moulding, Dale A., Moeendarbary, Emad, Valon, Leo, Record, Julien, Charras, Guillaume T., Thrasher, Adrian J.

“…The constitutively active mutant of the Wiskott-Aldrich Syndrome protein (CA-WASp) is the cause of X-linked neutropenia and is linked with genomic instability…”
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A congenital activating mutant of WASp causes altered plasma membrane topography and adhesion under flow in lymphocytes by Burns, Siobhan O., Killock, David J., Moulding, Dale A., Metelo, Joao, Nunes, Joao, Taylor, Ruth R., Forge, Andrew, Thrasher, Adrian J., Ivetic, Aleksandar

“…Leukocytes rely on dynamic actin-dependent changes in cell shape to pass through blood vessels, which is fundamental to immune surveillance. Wiskott-Aldrich…”
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Sodium Salicylate Promotes Neutrophil Apoptosis by Stimulating Caspase-Dependent Turnover of Mcl-1 by Derouet, Mathieu, Thomas, Luke, Moulding, Dale A, Akgul, Cahit, Cross, Andrew, Moots, Robert J, Edwards, Steven W

“…Mcl-1 is an antiapoptotic member of the Bcl-2 family of proteins that plays a central role in cell survival of neutrophils and other cells. The protein is…”
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Apoptosis is rapidly triggered by antisense depletion of MCL-1 in differentiating U937 cells by Moulding, Dale A., Giles, Richard V., Spiller, David G., White, Michael R. H., Tidd, David M., Edwards, Steven W.

“…Mcl-1 is a member of the Bcl-2 protein family, which has been shown to delay apoptosis in transfection and/or overexpression experiments. As yet no gene…”
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Apoptosis is rapidly triggered by antisense depletion of MCL-1 in differentiating U937 cells by Moulding, Dale A., Giles, Richard V., Spiller, David G., White, Michael R.H., Tidd, David M., Edwards, Steven W.

“…Mcl-1 is a member of the Bcl-2 protein family, which has been shown to delay apoptosis in transfection and/or overexpression experiments. As yet no gene…”
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