Search Results - "Mould, Arne"

Cellular calcium in bipolar disorder: systematic review and meta-analysis by Harrison, Paul J., Hall, Nicola, Mould, Arne, Al-Juffali, Noura, Tunbridge, Elizabeth M.

“…Calcium signalling has long been implicated in bipolar disorder, especially by reports of altered intracellular calcium ion concentrations ([Ca 2+ ]). However,…”
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Targeting synaptic plasticity in schizophrenia: insights from genomic studies by Mould, Arne W., Hall, Nicola A., Milosevic, Ira, Tunbridge, Elizabeth M.

“…Patients with schizophrenia experience cognitive dysfunction and negative symptoms that do not respond to current drug treatments. Historical evidence is…”
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PCGF3/5–PRC1 initiates Polycomb recruitment in X chromosome inactivation by Almeida, Mafalda, Pintacuda, Greta, Masui, Osamu, Koseki, Yoko, Gdula, Michal, Cerase, Andrea, Brown, David, Mould, Arne, Innocent, Cassandravictoria, Nakayama, Manabu, Schermelleh, Lothar, Nesterova, Tatyana B., Koseki, Haruhiko, Brockdorff, Neil

“…Recruitment of the Polycomb repressive complexes PRC1 and PRC2 by Xist RNA is an important paradigm for chromatin regulation by long noncoding RNAs. Here, we…”
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Single-cell RNA-seq reveals cell type-specific transcriptional signatures at the maternal–foetal interface during pregnancy by Nelson, Andrew C., Mould, Arne W., Bikoff, Elizabeth K., Robertson, Elizabeth J.

“…Growth and survival of the mammalian embryo within the uterine environment depends on the placenta, a highly complex vascularized organ comprised of both…”
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Smchd1 regulates long-range chromatin interactions on the inactive X chromosome and at Hox clusters by Jansz, Natasha, Keniry, Andrew, Trussart, Marie, Bildsoe, Heidi, Beck, Tamara, Tonks, Ian D., Mould, Arne W., Hickey, Peter, Breslin, Kelsey, Iminitoff, Megan, Ritchie, Matthew E., McGlinn, Edwina, Kay, Graham F., Murphy, James M., Blewitt, Marnie E.

“…The regulation of higher-order chromatin structure is complex and dynamic, and a full understanding of the suite of mechanisms governing this architecture is…”
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Blimp1/Prdm1 Functions in Opposition to Irf1 to Maintain Neonatal Tolerance during Postnatal Intestinal Maturation by Mould, Arne W, Morgan, Marc A J, Nelson, Andrew C, Bikoff, Elizabeth K, Robertson, Elizabeth J

“…The neonatal intestine is a very complex and dynamic organ that must rapidly adapt and remodel in response to a barrage of environmental stimuli during the…”
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Lhx1 functions together with Otx2, Foxa2, and Ldb1 to govern anterior mesendoderm, node, and midline development by Costello, Ita, Nowotschin, Sonja, Sun, Xin, Mould, Arne W, Hadjantonakis, Anna-Katerina, Bikoff, Elizabeth K, Robertson, Elizabeth J

“…Gene regulatory networks controlling functional activities of spatially and temporally distinct endodermal cell populations in the early mouse embryo remain…”
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Kalirin as a Novel Treatment Target for Cognitive Dysfunction in Schizophrenia by Mould, Arne W., Al-Juffali, Noura, von Delft, Annette, Brennan, Paul E., Tunbridge, Elizabeth M.

“…The cognitive dysfunction experienced by patients with schizophrenia represents a major unmet clinical need. We believe that enhancing synaptic function and…”
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The transcriptional repressor Blimp1/PRDM1 regulates the maternal decidual response in mice by Goolam, Mubeen, Xypolita, Maria-Eleni, Costello, Ita, Lydon, John P., DeMayo, Francesco J., Bikoff, Elizabeth K., Robertson, Elizabeth J., Mould, Arne W.

“…The transcriptional repressor Blimp1 controls cell fate decisions in the developing embryo and adult tissues. Here we describe Blimp1 expression and functional…”
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transcriptional repressor Blimp1/Prdm1 regulates postnatal reprogramming of intestinal enterocytes by Harper, James, Mould, Arne, Andrews, Robert M, Bikoff, Elizabeth K, Robertson, Elizabeth J

“…Female mammals produce milk to feed their newborn offspring before teeth develop and permit the consumption of solid food. Intestinal enterocytes dramatically…”
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Blimp-1/PRDM1 is a critical regulator of Type III Interferon responses in mammary epithelial cells by Elias, Salah, Robertson, Elizabeth J., Bikoff, Elizabeth K., Mould, Arne W.

“…The transcriptional repressor Blimp-1 originally cloned as a silencer of type I interferon (IFN)-β gene expression controls cell fate decisions in multiple…”
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Mapping the chromatin landscape and Blimp1 transcriptional targets that regulate trophoblast differentiation by Nelson, Andrew C., Mould, Arne W., Bikoff, Elizabeth K., Robertson, Elizabeth J.

“…Trophoblast stem cells (TSCs) give rise to specialized cell types within the placenta. However, the regulatory mechanisms that guide trophoblast cell fate…”
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Long read sequencing reveals novel isoforms and insights into splicing regulation during cell state changes by Wright, David J, Hall, Nicola A L, Irish, Naomi, Man, Angela L, Glynn, Will, Mould, Arne, Angeles, Alejandro De Los, Angiolini, Emily, Swarbreck, David, Gharbi, Karim, Tunbridge, Elizabeth M, Haerty, Wilfried

“…Alternative splicing is a key mechanism underlying cellular differentiation and a driver of complexity in mammalian neuronal tissues. However, understanding of…”
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Combinatorial Smad2/3 Activities Downstream of Nodal Signaling Maintain Embryonic/Extra-Embryonic Cell Identities during Lineage Priming by Senft, Anna D., Costello, Ita, King, Hamish W., Mould, Arne W., Bikoff, Elizabeth K., Robertson, Elizabeth J.

“…Epiblast cells in the early post-implantation stage mammalian embryo undergo a transition described as lineage priming before cell fate allocation, but…”
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Blimp1/Prdm1 governs terminal differentiation of endovascular trophoblast giant cells and defines multipotent progenitors in the developing placenta by Mould, Arne, Morgan, Marc A J, Li, Li, Bikoff, Elizabeth K, Robertson, Elizabeth J

“…Developmental arrest of Blimp1/Prdm1 mutant embryos at around embryonic day 10.5 (E10.5) has been attributed to placental disturbances. Here we investigate…”
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Smchd1 regulates a subset of autosomal genes subject to monoallelic expression in addition to being critical for X inactivation by Mould, Arne W, Pang, Zhenyi, Pakusch, Miha, Tonks, Ian D, Stark, Mitchell, Carrie, Dianne, Mukhopadhyay, Pamela, Seidel, Annica, Ellis, Jonathan J, Deakin, Janine, Wakefield, Matthew J, Krause, Lutz, Blewitt, Marnie E, Kay, Graham F

“…Smchd1 is an epigenetic modifier essential for X chromosome inactivation: female embryos lacking Smchd1 fail during midgestational development. Male mice are…”
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The transcriptional repressor Blimp1 is expressed in rare luminal progenitors and is essential for mammary gland development by Ahmed, Mohammed I, Elias, Salah, Mould, Arne W, Bikoff, Elizabeth K, Robertson, Elizabeth J

“…Mammary gland morphogenesis depends on a tight balance between cell proliferation, differentiation and apoptosis, to create a defined functional hierarchy…”
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Correction to: Long read sequencing reveals novel isoforms and insights into splicing regulation during cell state changes by Wright, David J, Hall, Nicola A L, Irish, Naomi, Man, Angela L, Glynn, Will, Mould, Arne, Angeles, Alejandro De Los, Angiolini, Emily, Swarbreck, David, Gharbi, Karim, Tunbridge, Elizabeth M, Haerty, Wilfried

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Menin and p53 have non-synergistic effects on tumorigenesis in mice by Loffler, Kelly A, Mould, Arne W, Waring, Paul M, Hayward, Nicholas K, Kay, Graham F

“…While it is now more than a decade since the first description of the gene mutation underlying the tumour predisposition syndrome multiple endocrine neoplasia…”
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The Oxford study of Calcium channel Antagonism, Cognition, Mood instability and Sleep (OxCaMS): study protocol for a randomised controlled, experimental medicine study by Atkinson, Lauren Z, Colbourne, Lucy, Smith, Alexander, Harmer, Catherine H, Nobre, Anna C, Rendell, Jennifer, Jones, Helen, Hinds, Christopher, Mould, Arne, Tunbridge, Elizabeth M, Cipriani, Andrea, Geddes, John R, Saunders, Kate E A, Harrison, Paul J

“…The discovery that voltage-gated calcium channel genes such as CACNA1C are part of the aetiology of psychiatric disorders has rekindled interest in the…”
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