The Westward Journey of Alfalfa Leaf Curl Virus

Alfalfa leaf curl virus (ALCV), which causes severe disease symptoms in alfalfa ( L.) and is transmitted by the widespread aphid species, Koch, has been found throughout the Mediterranean basin as well as in Iran and Argentina. Here we reconstruct the evolutionary history of ALCV and attempt to dete...

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Bibliographic Details
Published in:	Viruses Vol. 10; no. 10; p. 542
Main Authors:	Davoodi, Zohreh, Bejerman, Nicolás, Richet, Cécile, Filloux, Denis, Kumari, Safaa G, Chatzivassiliou, Elisavet K, Galzi, Serge, Julian, Charlotte, Samarfard, Samira, Trucco, Verónica, Giolitti, Fabián, Fiallo-Olivé, Elvira, Navas-Castillo, Jesús, Asaad, Nader, Moukahel, Abdul Rahman, Hijazi, Jomana, Mghandef, Samia, Heydarnejad, Jahangir, Massumi, Hossein, Varsani, Arvind, Dietzgen, Ralf G, Harkins, Gordon W, Martin, Darren P, Roumagnac, Philippe
Format:	Journal Article
Language:	English
Published:	Switzerland MDPI 04-10-2018 MDPI AG
Subjects:	alfalfa Alfalfa leaf curl virus DNA, Viral - genetics evolutionary history Geminiviridae - classification Geminiviridae - genetics Geminiviridae - isolation & purification geminivirus Genetic Variation Genome, Viral - drug effects Geography Life Sciences Medicago sativa - virology Microbiology and Parasitology Phylogeny Plant Diseases - virology Plant Viruses - classification Plant Viruses - genetics Plant Viruses - isolation & purification Recombination, Genetic Sequence Analysis, DNA Viral Proteins - genetics Virology Alfalfa leaf curl virus alfalfa evolutionary history geminivirus
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Summary:	Alfalfa leaf curl virus (ALCV), which causes severe disease symptoms in alfalfa ( L.) and is transmitted by the widespread aphid species, Koch, has been found throughout the Mediterranean basin as well as in Iran and Argentina. Here we reconstruct the evolutionary history of ALCV and attempt to determine whether the recent discovery and widespread detection of ALCV is attributable either to past diagnostic biases or to the emergence and global spread of the virus over the past few years. One hundred and twenty ALCV complete genome sequences recovered from ten countries were analyzed and four ALCV genotypes (ALCV-A, ALCV-B, ALCV-C, and ALCV-D) were clearly distinguished. We further confirm that ALCV isolates are highly recombinogenic and that recombination has been a major determinant in the origins of the various genotypes. Collectively, the sequence data support the hypothesis that, of all the analyzed locations, ALCV likely emerged and diversified in the Middle East before spreading to the western Mediterranean basin and Argentina.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Both authors contributed equally to this work.
ISSN:	1999-4915 1999-4915
DOI:	10.3390/v10100542