Search Results - "Mouhieddine, Tarek H."

A tertiary center experience of multiple myeloma patients with COVID-19: lessons learned and the path forward by Wang, Bo, Van Oekelen, Oliver, Mouhieddine, Tarek H, Del Valle, Diane Marie, Richter, Joshua, Cho, Hearn Jay, Richard, Shambavi, Chari, Ajai, Gnjatic, Sacha, Merad, Miriam, Jagannath, Sundar, Parekh, Samir, Madduri, Deepu

“…The COVID-19 pandemic, caused by SARS-CoV-2 virus, has resulted in over 100,000 deaths in the USA. Our institution has treated over 2000 COVID-19 patients…”
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Single cell characterization of myeloma and its precursor conditions reveals transcriptional signatures of early tumorigenesis by Boiarsky, Rebecca, Haradhvala, Nicholas J., Alberge, Jean-Baptiste, Sklavenitis-Pistofidis, Romanos, Mouhieddine, Tarek H., Zavidij, Oksana, Shih, Ming-Chieh, Firer, Danielle, Miller, Mendy, El-Khoury, Habib, Anand, Shankara K., Aguet, François, Sontag, David, Ghobrial, Irene M., Getz, Gad

“…Multiple myeloma is a plasma cell malignancy almost always preceded by precursor conditions, but low tumor burden of these early stages has hindered the study…”
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Blocking IFNAR1 inhibits multiple myeloma-driven Treg expansion and immunosuppression by Kawano, Yawara, Zavidij, Oksana, Park, Jihye, Moschetta, Michele, Kokubun, Katsutoshi, Mouhieddine, Tarek H, Manier, Salomon, Mishima, Yuji, Murakami, Naoka, Bustoros, Mark, Pistofidis, Romanos Sklavenitis, Reidy, Mairead, Shen, Yu J, Rahmat, Mahshid, Lukyanchykov, Pavlo, Karreci, Esilida Sula, Tsukamoto, Shokichi, Shi, Jiantao, Takagi, Satoshi, Huynh, Daisy, Sacco, Antonio, Tai, Yu-Tzu, Chesi, Marta, Bergsagel, P Leif, Roccaro, Aldo M, Azzi, Jamil, Ghobrial, Irene M

“…Despite significant advances in the treatment of multiple myeloma (MM), most patients succumb to disease progression. One of the major immunosuppressive…”
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The Akt/mTOR pathway in cancer stem/progenitor cells is a potential therapeutic target for glioblastoma and neuroblastoma by Bahmad, Hisham F, Mouhieddine, Tarek H, Chalhoub, Reda M, Assi, Sahar, Araji, Tarek, Chamaa, Farah, Itani, Muhieddine M, Nokkari, Amaly, Kobeissy, Firas, Daoud, Georges, Abou-Kheir, Wassim

“…Nervous system tumors represent some of the highly aggressive cancers in both children and adults, particularly neuroblastoma and glioblastoma. Many studies…”
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Differences in Nanoparticle Uptake in Transplanted and Autochthonous Models of Pancreatic Cancer by Tao, Zhimin, Muzumdar, Mandar Deepak, Detappe, Alexandre, Huang, Xing, Xu, Eric S, Yu, Yingjie, Mouhieddine, Tarek H, Song, Haiqin, Jacks, Tyler, Ghoroghchian, P. Peter

“…Human pancreatic ductal adenocarcinoma (PDAC) contains a distinctively dense stroma that limits the accessibility of anticancer drugs, contributing to its poor…”
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MicroRNA-34a regulates WNT/TCF7 signaling and inhibits bone metastasis in Ras-activated prostate cancer by Chen, Wei-Yu, Liu, Shih-Yang, Chang, Yung-Sheng, Yin, Juan Juan, Yeh, Hsiu-Lien, Mouhieddine, Tarek H, Hadadeh, Ola, Abou-Kheir, Wassim, Liu, Yen-Nien

“…Aberrant activation of Ras and WNT signaling are key events that have been shown to be up-regulated in prostate cancer that has metastasized to the bone…”
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Hemophagocytic relapsed intramedullary plasmacytoma by Mouhieddine, Tarek H., Barlogie, Bart, Teruya-Feldstein, Julie

“…We report a case of a relapsed hemophagocytic intramedullary plasmacytoma, previously non-phagocytic, in conjunction with development of a new clone with…”
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Berberis libanotica Ehrenb extract shows anti-neoplastic effects on prostate cancer stem/progenitor cells by El-Merahbi, Rabih, Liu, Yen-Nien, Eid, Assaad, Daoud, Georges, Hosry, Leina, Monzer, Alissar, Mouhieddine, Tarek H, Hamade, Aline, Najjar, Fadia, Abou-Kheir, Wassim

“…Cancer stem cells (CSCs), including those of advanced prostate cancer, are a suggested reason for tumor resistance toward conventional tumor therapy…”
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Metformin and Ara-a Effectively Suppress Brain Cancer by Targeting Cancer Stem/Progenitor Cells by Mouhieddine, Tarek H, Nokkari, Amaly, Itani, Muhieddine M, Chamaa, Farah, Bahmad, Hisham, Monzer, Alissar, El-Merahbi, Rabih, Daoud, Georges, Eid, Assaad, Kobeissy, Firas H, Abou-Kheir, Wassim

“…Gliomas and neuroblastomas pose a great health burden worldwide with a poor and moderate prognosis, respectively. Many studies have tried to find effective…”
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The Effect of Chronic Methamphetamine Exposure on the Hippocampal and Olfactory Bulb Neuroproteomes of Rats by Zhu, Rui, Yang, Tianjiao, Kobeissy, Firas, Mouhieddine, Tarek H, Raad, Mohamad, Nokkari, Amaly, Gold, Mark S, Wang, Kevin K, Mechref, Yehia

“…Nowadays, drug abuse and addiction are serious public health problems in the USA. Methamphetamine (METH) is one of the most abused drugs and is known to cause…”
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Assessing the Lebanese population for their knowledge, attitudes and practices of antibiotic usage by Mouhieddine, Tarek H, Olleik, Zeinab, Itani, Muhieddine M, Kawtharani, Soumayah, Nassar, Hussein, Hassoun, Rached, Houmani, Zeinab, Zein, Zeinab El, Fakih, Ramy, Mortada, Ibrahim K, Mohsen, Youssef, Kanafani, Zeina, Tamim, Hani

“…Summary Antibiotic-resistant bacteria has become a global phenomenon, mainly due to the inappropriate use of antibiotics. There are no studies in Lebanon to…”
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How to Identify and Manage High-Risk Smoldering Multiple Myeloma by Mouhieddine, Tarek H

“…It elucidates advancements in identifying and managing high-risk smoldering multiple myeloma (SMM), moving from observation strategies to intervention…”
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Characterization of the Kallikrein-Kinin System Post Chemical Neuronal Injury: An In Vitro Biochemical and Neuroproteomics Assessment by Nokkari, Amaly, Mouhieddine, Tarek H, Itani, Muhieddine M, Abou-Kheir, Wassim, Daoud, Georges, Zhu, Rui, Mechref, Yehia, Meshref, Yehia, Soueid, Jihane, Al Hariri, Moustafa, Mondello, Stefania, Jaffa, Ayad A, Kobeissy, Firas

“…Traumatic Brain Injury (TBI) is the result of a mechanical impact on the brain provoking mild, moderate or severe symptoms. It is acknowledged that TBI leads…”
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Monoclonal gammopathy of undetermined significance by Mouhieddine, Tarek H., Weeks, Lachelle D., Ghobrial, Irene M.

“…Monoclonal gammopathy of undetermined significance (MGUS) is a premalignant plasma cell dyscrasia that consistently precedes multiple myeloma (MM) with a 1%…”
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Correction: Characterization of the Kallikrein-Kinin System Post Chemical Neuronal Injury: An In Vitro Biochemical and Neuroproteomics Assessment by Nokkari, Amaly, Mouhieddine, Tarek H, Itani, Muhieddine M, Abou-Kheir, Wassim, Daoud, Georges, Zhu, Rui, Mechref, Yehia, Soueid, Jihane, Al Hariri, Moustafa, Mondello, Stefania, Jaffa, Ayad A, Kobeissy, Firas

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Highly variable SARS-CoV-2 spike antibody responses to two doses of COVID-19 RNA vaccination in patients with multiple myeloma by Van Oekelen, Oliver, Gleason, Charles R., Agte, Sarita, Srivastava, Komal, Beach, Katherine F., Aleman, Adolfo, Kappes, Katerina, Banu, Radhika, Bermúdez-González, Maria C., Chernet, Rachel L., Ferreri, Emily D., Floda, Daniel L., Firpo-Betancourt, Adolfo, Kleiner, Giulio, Russo, Kayla T., Salimbangon, Ashley-Beathrese T., Saksena, Miti S., Shin, Amber A., Matthews, Julia, Mendez, Wanni, Sominsky, Levy, Mulder, Lubbertus C.F., Mendu, Rao, Mouhieddine, Tarek H., Wang, Bo, Chari, Ajai, Cordon-Cardo, Carlos, Krammer, Florian, Jagannath, Sundar, Simon, Viviana, Wajnberg, Ania, Parekh, Samir

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Single-cell multi-omics of human clonal hematopoiesis reveals that DNMT3A R882 mutations perturb early progenitor states through selective hypomethylation by Nam, Anna S., Dusaj, Neville, Izzo, Franco, Murali, Rekha, Myers, Robert M., Mouhieddine, Tarek H., Sotelo, Jesus, Benbarche, Salima, Waarts, Michael, Gaiti, Federico, Tahri, Sabrin, Levine, Ross, Abdel-Wahab, Omar, Godley, Lucy A., Chaligne, Ronan, Ghobrial, Irene, Landau, Dan A.

“…Somatic mutations in cancer genes have been detected in clonal expansions across healthy human tissue, including in clonal hematopoiesis. However, because…”
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Revisiting the role of alkylating agents in multiple myeloma: Up-to-date evidence and future perspectives by Costa, Bruno Almeida, Mouhieddine, Tarek H., Ortiz, Ricardo J., Richter, Joshua

“…From the 1960s to the early 2000s, alkylating agents (e.g., melphalan, cyclophosphamide, and bendamustine) remained a key component of standard therapy for…”
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Outcomes with panobinostat in heavily pretreated multiple myeloma patients by Pan, Darren, Mouhieddine, Tarek H., Upadhyay, Ranjan, Casasanta, Nicole, Lee, Angela, Zubizarreta, Nicole, Moshier, Erin, Richter, Joshua

“…Panobinostat is an oral pan histone-deacetylase inhibitor used in the treatment of relapsed and refractory multiple myeloma. Previously published studies of…”
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Advancements in Nanomedicine for Multiple Myeloma by Detappe, Alexandre, Bustoros, Mark, Mouhieddine, Tarek H., Ghoroghchian, P. Peter

“…In the past decades, considerable progress has been made in our understanding and treatment of multiple myeloma. Several challenges remain including our…”
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