Biomimetic Nanovesicles—Sources, Design, Production Methods, and Applications

Biomimetic Nanovesicles—Sources, Design, Production Methods, and Applications

Despite all the progress in the field of liposomes and nanoparticles for applications as drug and gene delivery systems, the specific targeting and immune system escape capabilities of these systems are still limited. Biomimetic nanovesicles emerged as a strategy to overcome these and other limitati...

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Bibliographic Details
Published in:Pharmaceutics Vol. 14; no. 10; p. 2008
Main Authors: Mougenot, Marcel Franco, Pereira, Vanessa Sousa, Costa, Ana Letícia Rodrigues, Lancellotti, Marcelo, Porcionatto, Marimelia Aparecida, da Silveira, Juliano Coelho, de la Torre, Lucimara Gaziola
Format: Journal Article
Language:English
Published: Basel MDPI AG 22-09-2022
MDPI
Subjects:
Analysis
Antibodies
Bacteria
Biocompatibility
Biomimetics
Clinical trials
Coronaviruses
drug delivery
Drug delivery systems
Drugs
extracellular vesicles
gene delivery
Genetic engineering
Gram-negative bacteria
Health aspects
Immune system
Influenza
Lipids
liposome
Liposomes
Membranes
Methods
Nanoparticles
Nanotechnology
Proteins
Review
vaccine
Vaccines
Vehicles
Viruses
Netherlands
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Summary:Despite all the progress in the field of liposomes and nanoparticles for applications as drug and gene delivery systems, the specific targeting and immune system escape capabilities of these systems are still limited. Biomimetic nanovesicles emerged as a strategy to overcome these and other limitations associated with synthetic carriers, such as short circulation time, cytotoxicity, and difficulty in crossing biological barriers, since many of the desirable abilities of drug delivery systems are innate characteristics of biological vesicles. Thus, the question arises: would biomimetic nanovesicles be responsible for addressing these advances? It is currently known that biomimetic nanovesicles (BNV) can combine the intrinsic advantages of natural materials with the well-known production methods and controllability of synthetic systems. Besides, the development of the biotechnology and nanotechnology fields has provided a better understanding of the functionalities of biological vesicles and the means for the design and production of biomimetic nanovesicles (BNV). Based on this, this work will focus on tracking the main research on biomimetic nanovesicles (BNV) applied as drug and gene delivery systems, and for vaccines applications. In addition, it will describe the different sources of natural vesicles, the technical perspectives on obtaining them, and the possibility of their hybridization with synthetic liposomes.
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ISSN:1999-4923
1999-4923
DOI:10.3390/pharmaceutics14102008