Search Results - "Moudrianakis, Evangelos N."

Experimental evidence for the role of domain swapping in the evolution of the histone fold by Hadjithomas, Michalis, Moudrianakis, Evangelos N

“…The histone fold forms the fundamental endoskeleton of the protein core of the nucleosome and is also found in several transcription factors. We have…”
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An Asymmetric Model for the Nucleosome: A Binding Site for Linker Histones Inside the DNA Gyres by Pruss, Dmitry, Bartholomew, Blaine, Persinger, Jim, Hayes, Jeffrey, Arents, Gina, Moudrianakis, Evangelos N., Wolffe, Alan P.

“…Histone-DNA contacts within a nucleosome influence the function of trans-acting factors and the molecular machines required to activate the transcription…”
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Thermodynamic Studies of the Core Histones:  pH and Ionic Strength Effects on the Stability of the (H3−H4)/(H3−H4)2 System by Karantza, Vassiliki, Freire, Ernesto, Moudrianakis, Evangelos N

“…The self-associative behavior and the thermal stability of the H3/H4 histone complex was studied in low-ionic strength conditions by several physicochemical…”
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Thermodynamic studies of the core histones: Ionic strength and pH dependence of H2A-H2B dimer stability by Karantza, Vassiliki, Baxevanis, Andreas D, Freire, Ernesto, Moudrianakis, Evangelos N

“…The thermal stability of the core histone dimer H2A-H2B has been studied by high-sensitivity differential scanning calorimetry and circular dichroism…”
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The Histone Fold: A Ubiquitous Architectural Motif Utilized in DNA Compaction and Protein Dimerization by Arents, Gina, Moudrianakis, Evangelos N.

“…The histones of all eukaryotes show only a low degree of primary structure homology, but our earlier crystallographic results defined a three-dimensional…”
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Topography of the Histone Octamer Surface: Repeating Structural Motifs Utilized in the Docking of Nucleosomal DNA by Arents, Gina, Moudrianakis, Evangelos N.

“…The histone octamer core of the nucleosome is a protein superhelix of four spirally arrayed histone dimers. The cylindrical face of this superhelix is marked…”
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The Histone Octamer Is Invisible When NF-κB Binds to the Nucleosome by Angelov, Dimitar, Lenouvel, François, Hans, Fabienne, Müller, Christoph W., Bouvet, Philippe, Bednar, Jan, Moudrianakis, Evangelos N., Cadet, Jean, Dimitrov, Stefan

“…The transcription factor NF- Kappa B is involved in the transcriptional control of more than 150 genes, but the way it acts at the level of nucleosomal…”
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The histone core complex: an octamer assembled by two sets of protein-protein interactions by Eickbush, Thomas H, Moudrianakis, Evangelos N

“…A protein complex, extracted from calf thymus chromatin with 2 M NaCl, pH 7.5, containing approximately equal molar ratios of histones H2A, H2B, H3, and H4,…”
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Influence of Ions, Hydration, and the Transcriptional Inhibitor P4N on the Conformations of the Sp1 Binding Site by Dohm, Julie A., Hsu, Ming-Hua, Hwu, Jih-Ru, Huang, Ru Chih C., Moudrianakis, Evangelos N., Lattman, Eaton E., Gittis, Apostolos G.

“…Three crystal structures containing the entire Sp1 consensus sequence d(GGGGCGGGG) with two or three additional base-pairs on either the 5′ or 3′ ends and…”
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Thermodynamic Studies of the Core Histones:  Stability of the Octamer Subunits Is Not Altered by Removal of Their Terminal Domains by Karantza, Vassiliki, Freire, Ernesto, Moudrianakis, Evangelos N

“…We have investigated the role of the labile terminal domains of the core histones on the stability of the subunits of the protein core of the nucleosome by…”
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Histone octamer function in vivo: mutations in the dimer-tetramer interfaces disrupt both gene activation and repression by Santisteban, M.S, Arents, G, Moudrianakis, E.N, Smith, M.M

“…Within the core histone octamer each histone H4 interacts with each H2A-H2B dimer subunit through two binding surfaces. Tyrosines play a central role in these…”
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localization of histone H3.3 in germ line chromatin of Drosophila males as established with a histone H3.3-specific antiserum by Akhmanova, A, Miedema, K, Wang, Y, Bruggen, M. van, Berden, J.H.M, Moudrianakis, E.N, Hennig, W

“…A rabbit antiserum, specific for the histone H3.3 replacement variant, was raised with the aid of a histone H3.3-specific peptide. Immuno blot experiments…”
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Associative behavior of the histone (H3-H4)2 tetramer: dependence on ionic environment by Baxevanis, Andreas D, Godfrey, Jamie E, Moudrianakis, Evangelos N

“…Mixtures of histones H3 and H4 were examined by analytical ultracentrifugation and circular dichroism to determine their association behavior and secondary…”
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Crystallographic Structure of the Octameric Histone Core of the Nucleosome at a Resolution of 3.3 Å by Burlingame, Rufus W., Love, Warner E., Bi-Chen Wang Ron Hamlin, Xuong, Nguyen-Huu, Moudrianakis, Evangelos N.

“…The structure of the (H2A-H2B-H3-H4)$_{2}$ histone octamer has been determined by means of x-ray crystallographic techniques at a resolution of 3.3 angstroms…”
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Enhanced stability of histone octamers from plant nucleosomes: Role of H2A and H2B histones by Moehs, Charles P, Baxevanis, Andreas D, Moudrianakis, Evangelos N, Spiker, Steven

“…Gel filtration and sedimentation studies have previously established that the vertebrate animal core histone octamer is in equilibrium with an (H3-H4)2…”
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Spectropolarimetric analysis of the core histone octamer and its subunits by Godfrey, Jamie E, Baxevanis, Andreas D, Moudrianakis, Evangelos N

“…The secondary structure of the calf thymus core histone octamer, (H2A-H2B-H3-H4)2, and its two physiological subunits, the H2A-H2B dimer and (H3-H4)2 tetramer,…”
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A variety of DNA-binding and multimeric proteins contain the histone fold motif by Baxevanis, Andreas D., Arents, Gina, Moudrianakis, Evangelos N., Landsman, David

“…The histone fold motif has previously been Identified as a structural feature common to all four core histones and is involved In both histone-histone and…”
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Reversible association of calf thymus histones to form the symmetrical octamer (H2AH2BH3H4)2: a case of a mixed-associating system by Godfrey, Jamie E, Eickbush, Thomas H, Moudrianakis, Evangelos N

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Thiol reactivity of histone H3 in soluble and DNA-associated histone complexes: evidence for allosteric and torsional regulation by Feinstein, Douglas L, Moudrianakis, Evangelos N

“…The reactivity of chick erythrocyte and calf thymus histone H3 thiol groups toward 5,5'-dithiobis(2-nitrobenzoic acid) (DTNB) has been investigated both in the…”
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Amino acid substitutions in the structured domains of histones H3 and H4 partially relieve the requirement of the yeast SWI/SNF complex for transcription by Kruger, W, Peterson, C L, Sil, A, Coburn, C, Arents, G, Moudrianakis, E N, Herskowitz, I

“…Transcription of many yeast genes requires the SWI/SNF regulatory complex. Prior studies show that reduced transcription of the HO gene in swi and snf mutants…”
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