Search Results - "Moubarak, Rana S"

A novel mouse model demonstrates that oncogenic melanocyte stem cells engender melanoma resembling human disease by Sun, Qi, Lee, Wendy, Mohri, Yasuaki, Takeo, Makoto, Lim, Chae Ho, Xu, Xiaowei, Myung, Peggy, Atit, Radhika P., Taketo, M. Mark, Moubarak, Rana S., Schober, Markus, Osman, Iman, Gay, Denise L., Saur, Dieter, Nishimura, Emi K., Ito, Mayumi

“…Melanoma, the deadliest skin cancer, remains largely incurable at advanced stages. Currently, there is a lack of animal models that resemble human melanoma…”
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Sequential Activation of Poly(ADP-Ribose) Polymerase 1, Calpains, and Bax Is Essential in Apoptosis-Inducing Factor-Mediated Programmed Necrosis by Moubarak, Rana S., Yuste, Victor J., Artus, Cédric, Bouharrour, Aïda, Greer, Peter A., Menissier-de Murcia, Josiane, Susin, Santos A.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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In Vivo miRNA Decoy Screen Reveals miR-124a as a Suppressor of Melanoma Metastasis by Moubarak, Rana S, Koetz-Ploch, Lisa, Mullokandov, Gavriel, Gaziel, Avital, de Pablos-Aragoneses, Ana, Argibay, Diana, Kleffman, Kevin, Sokolova, Elena, Berwick, Marianne, Thomas, Nancy E, Osman, Iman, Brown, Brian D, Hernando, Eva

“…Melanoma is a highly prevalent cancer with an increasing incidence worldwide and high metastatic potential. Brain metastasis is a major complication of the…”
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FAIM-L regulation of XIAP degradation modulates Synaptic Long-Term Depression and Axon Degeneration by Martínez-Mármol, Ramón, Barneda-Zahonero, Bruna, Soto, David, Andrés, Rosa Maria, Coccia, Elena, Gasull, Xavier, Planells-Ferrer, Laura, Moubarak, Rana S., Soriano, Eduardo, Comella, Joan X.

“…Caspases have recently emerged as key regulators of axonal pruning and degeneration and of long-term depression (LTD), a long-lasting form of synaptic…”
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Identification and characterization of new isoforms of human fas apoptotic inhibitory molecule (FAIM) by Coccia, Elena, Calleja-Yagüe, Isabel, Planells-Ferrer, Laura, Sanuy, Blanca, Sanz, Belen, López-Soriano, Joaquin, Moubarak, Rana S, Munell, Francina, Barneda-Zahonero, Bruna, Comella, Joan X, Pérez-García, M Jose

“…Fas Apoptosis Inhibitory Molecule (FAIM) is an evolutionarily highly conserved death receptor antagonist, widely expressed and known to participate in…”
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Epigenetic Silencing of CDR1as Drives IGF2BP3-Mediated Melanoma Invasion and Metastasis by Hanniford, Douglas, Ulloa-Morales, Alejandro, Karz, Alcida, Berzoti-Coelho, Maria Gabriela, Moubarak, Rana S., Sánchez-Sendra, Beatriz, Kloetgen, Andreas, Davalos, Veronica, Imig, Jochen, Wu, Pamela, Vasudevaraja, Varshini, Argibay, Diana, Lilja, Karin, Tabaglio, Tommaso, Monteagudo, Carlos, Guccione, Ernesto, Tsirigos, Aristotelis, Osman, Iman, Aifantis, Iannis, Hernando, Eva

“…Metastasis is the primary cause of death of cancer patients. Dissecting mechanisms governing metastatic spread may uncover important tumor biology and/or yield…”
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AIFsh, a Novel Apoptosis-inducing Factor (AIF) Pro-apoptotic Isoform with Potential Pathological Relevance in Human Cancer by Delettre, Cécile, Yuste, Victor J., Moubarak, Rana S., Bras, Marlène, Lesbordes-Brion, Jeanne-Claire, Petres, Stéphane, Bellalou, Jacques, Susin, Santos A.

“…AIF is a main mediator of caspase-independent cell death. It is encoded by a single gene located on chromosome X, region q25–26 and A6 in humans and mice,…”
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The Contribution of Apoptosis-inducing Factor, Caspase-activated DNase, and Inhibitor of Caspase-activated DNase to the Nuclear Phenotype and DNA Degradation during Apoptosis by Yuste, Victor J., Sánchez-López, Isabel, Solé, Carme, Moubarak, Rana S., Bayascas, José R., Dolcet, Xavier, Encinas, Mario, Susin, Santos A., Comella, Joan X.

“…We have assessed the contribution of apoptosis-inducing factor (AIF) and inhibitor of caspase-activated DNase (ICAD) to the nuclear morphology and DNA…”
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Identification and Characterization of AIFsh2, a Mitochondrial Apoptosis-inducing Factor (AIF) Isoform with NADH Oxidase Activity by Delettre, Cécile, Yuste, Victor J., Moubarak, Rana S., Bras, Marlène, Robert, Nadine, Susin, Santos A.

“…Apoptosis-inducing factor (AIF) is a bifunctional NADH oxidase involved in mitochondrial respiration and caspase-independent apoptosis. Three alternatively…”
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FBXW7 modulates cellular stress response and metastatic potential through HSF1 post-translational modification by Kourtis, Nikos, Moubarak, Rana S., Aranda-Orgilles, Beatriz, Lui, Kevin, Aydin, Iraz T., Trimarchi, Thomas, Darvishian, Farbod, Salvaggio, Christine, Zhong, Judy, Bhatt, Kamala, Chen, Emily I., Celebi, Julide T., Lazaris, Charalampos, Tsirigos, Aristotelis, Osman, Iman, Hernando, Eva, Aifantis, Iannis

“…Heat-shock factor 1 (HSF1) orchestrates the heat-shock response in eukaryotes. Although this pathway has evolved to help cells adapt in the presence of…”
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A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis by Shadaloey, Arman Alberto Sorin, Karz, Alcida, Moubarak, Rana S, Agrawal, Praveen, Levinson, Grace, Kleffman, Kevin, Aristizabal, Orlando, Osman, Iman, Wadghiri, Youssef Z, Hernando, Eva

“…Metastasis is a complex process, requiring cells to overcome barriers that are only incompletely modeled by in vitro assays. A systematic workflow was…”
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The histone demethylase PHF8 regulates TGFβ signaling and promotes melanoma metastasis by Moubarak, Rana S, de Pablos-Aragoneses, Ana, Ortiz-Barahona, Vanessa, Gong, Yixiao, Gowen, Michael, Dolgalev, Igor, Shadaloey, Sorin A A, Argibay, Diana, Karz, Alcida, Von Itter, Richard, Vega-Sáenz de Miera, Eleazar Carmelo, Sokolova, Elena, Darvishian, Farbod, Tsirigos, Aristotelis, Osman, Iman, Hernando, Eva

“…The contribution of epigenetic dysregulation to metastasis remains understudied. Through a meta-analysis of gene expression datasets followed by a mini-screen,…”
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Lifeguard Inhibits Fas Ligand-mediated Endoplasmic Reticulum-Calcium Release Mandatory for Apoptosis in Type II Apoptotic Cells by Urresti, Jorge, Ruiz-Meana, Marisol, Coccia, Elena, Arévalo, Juan Carlos, Castellano, José, Fernández-Sanz, Celia, Galenkamp, Koen M.O., Planells-Ferrer, Laura, Moubarak, Rana S., Llecha-Cano, Núria, Reix, Stéphanie, García-Dorado, David, Barneda-Zahonero, Bruna, Comella, Joan X.

“…Death receptors are members of the tumor necrosis factor receptor superfamily involved in the extrinsic apoptotic pathway. Lifeguard (LFG) is a death receptor…”
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SIVA-1 regulates apoptosis and synaptic function by modulating XIAP interaction with the death receptor antagonist FAIM-L by Coccia, Elena, Planells-Ferrer, Laura, Badillos-Rodríguez, Raquel, Pascual, Marta, Segura, Miguel F., Fernández-Hernández, Rita, López-Soriano, Joaquin, Garí, Eloi, Soriano, Eduardo, Barneda-Zahonero, Bruna, Moubarak, Rana S., Pérez-García, M. Jose, Comella, Joan X.

“…The long isoform of Fas apoptosis inhibitory molecule (FAIM-L) is a neuron-specific death receptor antagonist that modulates apoptotic cell death and…”
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FAIM-L is an IAP-binding protein that inhibits XIAP ubiquitinylation and protects from Fas-induced apoptosis by Moubarak, Rana S, Planells-Ferrer, Laura, Urresti, Jorge, Reix, Stéphanie, Segura, Miguel F, Carriba, Paulina, Marqués-Fernàndez, Fernando, Sole, Carme, Llecha-Cano, Nuria, Lopez-Soriano, Joaquin, Sanchis, Daniel, Yuste, Victor J, Comella, Joan X

“…The neuronal long isoform of Fas Apoptotic Inhibitory Molecule (FAIM-L) protects from death receptor (DR)-induced apoptosis, yet its mechanism of protection…”
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TNFα sensitizes neuroblastoma cells to FasL-, cisplatin- and etoposide-induced cell death by NF-κB-mediated expression of Fas by Galenkamp, Koen Mo, Carriba, Paulina, Urresti, Jorge, Planells-Ferrer, Laura, Coccia, Elena, Lopez-Soriano, Joaquín, Barneda-Zahonero, Bruna, Moubarak, Rana S, Segura, Miguel F, Comella, Joan X

“…Patients with high-risk neuroblastoma (NBL) tumors have a high mortality rate. Consequently, there is an urgent need for the development of new treatments for…”
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A pathway involving HDAC5, cFLIP and caspases regulates expression of the splicing regulator polypyrimidine tract binding protein in the heart by Ye, Junmei, Llorian, Miriam, Cardona, Maria, Rongvaux, Anthony, Moubarak, Rana S, Comella, Joan X, Bassel-Duby, Rhonda, Flavell, Richard A, Olson, Eric N, Smith, Christopher W J, Sanchis, Daniel

“…Polypyrimidine tract binding protein (PTB) regulates pre-mRNA splicing, having special relevance for determining gene expression in the differentiating muscle…”
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The Long Form of Fas Apoptotic Inhibitory Molecule Is Expressed Specifically in Neurons and Protects Them against Death Receptor-Triggered Apoptosis by Segura, Miguel F, Sole, Carme, Pascual, Marta, Moubarak, Rana S, Jose Perez-Garcia, M, Gozzelino, Raffaella, Iglesias, Victoria, Badiola, Nahuai, Bayascas, Jose R, Llecha, Nuria, Rodriguez-Alvarez, Jose, Soriano, Eduardo, Yuste, Victor J, Comella, Joan X

“…Death receptors (DRs) and their ligands are expressed in developing nervous system. However, neurons are generally resistant to death induction through DRs and…”
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NF-κB activation fails to protect cells to TNFα-induced apoptosis in the absence of Bcl-xL, but not Mcl-1, Bcl-2 or Bcl-w by Casanelles, Elisenda, Gozzelino, Raffaella, Marqués-Fernández, Fernando, Iglesias-Guimarais, Victoria, Garcia-Belinchón, Mercè, Sánchez-Osuna, María, Solé, Carme, Moubarak, Rana S., Comella, Joan X., Yuste, Victor J.

“…TNFα can promote either cell survival or cell death. The activation of NF-κB plays a central role in cell survival while its inhibition makes TNFα-triggered…”
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X-linked Inhibitor of Apoptosis Protein negatively regulates neuronal differentiation through interaction with cRAF and Trk by Fadó, Rut, Moubarak, Rana S., Miñano-Molina, Alfredo J., Barneda-Zahonero, Bruna, Valero, Jorge, Saura, Carlos A., Moran, Julio, Comella, Joan X., Rodríguez-Álvarez, José

“…X-linked Inhibitor of apoptosis protein (XIAP) has been classically identified as a cell death regulator. Here, we demonstrate a novel function of XIAP as a…”
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