Search Results - "Mottolese, Nicola"

Inhibition of microglia overactivation restores neuronal survival in a mouse model of CDKL5 deficiency disorder by Galvani, Giuseppe, Mottolese, Nicola, Gennaccaro, Laura, Loi, Manuela, Medici, Giorgio, Tassinari, Marianna, Fuchs, Claudia, Ciani, Elisabetta, Trazzi, Stefania

“…CDKL5 deficiency disorder (CDD), a severe neurodevelopmental disorder characterized by early onset epilepsy, intellectual disability, and autistic features, is…”
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Luteolin Treatment Ameliorates Brain Development and Behavioral Performance in a Mouse Model of CDKL5 Deficiency Disorder by Tassinari, Marianna, Mottolese, Nicola, Galvani, Giuseppe, Ferrara, Domenico, Gennaccaro, Laura, Loi, Manuela, Medici, Giorgio, Candini, Giulia, Rimondini, Roberto, Ciani, Elisabetta, Trazzi, Stefania

“…CDKL5 deficiency disorder (CDD), a rare and severe neurodevelopmental disease caused by mutations in the X-linked CDKL5 gene, is characterized by early-onset…”
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Early-onset brain alterations during postnatal development in a mouse model of CDKL5 deficiency disorder by Tassinari, Marianna, Uguagliati, Beatrice, Trazzi, Stefania, Cerchier, Camilla Bruna, Cavina, Ottavia Vera, Mottolese, Nicola, Loi, Manuela, Candini, Giulia, Medici, Giorgio, Ciani, Elisabetta

“…Mutations in the CDKL5 gene are the cause of CDKL5 deficiency disorder (CDD), a rare and severe neurodevelopmental condition characterized by early-onset…”
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Treatment with a GSK-3β/HDAC Dual Inhibitor Restores Neuronal Survival and Maturation in an In Vitro and In Vivo Model of CDKL5 Deficiency Disorder by Loi, Manuela, Gennaccaro, Laura, Fuchs, Claudia, Trazzi, Stefania, Medici, Giorgio, Galvani, Giuseppe, Mottolese, Nicola, Tassinari, Marianna, Giorgini, Roberto Rimondini, Milelli, Andrea, Ciani, Elisabetta

“…Mutations in the X-linked cyclin-dependent kinase-like 5 ( ) gene cause a rare neurodevelopmental disorder characterized by early-onset seizures and severe…”
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Cardiac Functional and Structural Abnormalities in a Mouse Model of CDKL5 Deficiency Disorder by Loi, Manuela, Bastianini, Stefano, Candini, Giulia, Rizzardi, Nicola, Medici, Giorgio, Papa, Valentina, Gennaccaro, Laura, Mottolese, Nicola, Tassinari, Marianna, Uguagliati, Beatrice, Berteotti, Chiara, Martire, Viviana Lo, Zoccoli, Giovanna, Cenacchi, Giovanna, Trazzi, Stefania, Bergamini, Christian, Ciani, Elisabetta

“…CDKL5 (cyclin-dependent kinase-like 5) deficiency disorder (CDD) is a severe neurodevelopmental disease that mostly affects girls, who are heterozygous for…”
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Voluntary Running Improves Behavioral and Structural Abnormalities in a Mouse Model of CDKL5 Deficiency Disorder by Mottolese, Nicola, Uguagliati, Beatrice, Tassinari, Marianna, Cerchier, Camilla Bruna, Loi, Manuela, Candini, Giulia, Rimondini, Roberto, Medici, Giorgio, Trazzi, Stefania, Ciani, Elisabetta

“…Cyclin-dependent kinase-like 5 (CDKL5) deficiency disorder (CDD) is a rare neurodevelopmental disease caused by mutations in the X-linked CDKL5 gene. CDD is…”
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Autistic‐relevant behavioral phenotypes of a mouse model of cyclin‐dependent kinase‐like 5 deficiency disorder by Mottolese, Nicola, Coiffard, Oceane, Ferraguto, Celeste, Manolis, Athanasios, Ciani, Elisabetta, Pietropaolo, Susanna

“…Cyclin‐dependent kinase‐like 5 (CDKL5) deficiency disorder (CDD) is a neurodevelopmental disease caused by mutations in the X‐linked CDKL5 gene and…”
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Expression of a Secretable, Cell-Penetrating CDKL5 Protein Enhances the Efficacy of Gene Therapy for CDKL5 Deficiency Disorder by Medici, Giorgio, Tassinari, Marianna, Galvani, Giuseppe, Bastianini, Stefano, Gennaccaro, Laura, Loi, Manuela, Mottolese, Nicola, Alvente, Sara, Berteotti, Chiara, Sagona, Giulia, Lupori, Leonardo, Candini, Giulia, Baggett, Helen Rappe, Zoccoli, Giovanna, Giustetto, Maurizio, Muotri, Alysson, Pizzorusso, Tommaso, Nakai, Hiroyuki, Trazzi, Stefania, Ciani, Elisabetta

“…Although delivery of a wild-type copy of the mutated gene to cells represents the most effective approach for a monogenic disease, proof-of-concept studies…”
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Treatment with FRAX486 rescues neurobehavioral and metabolic alterations in a female mouse model of CDKL5 deficiency disorder by Fuchs, Claudia, Cosentino, Livia, Urbinati, Chiara, Talamo, Maria Cristina, Medici, Giorgio, Quattrini, Maria Cristina, Mottolese, Nicola, Pietraforte, Donatella, Fuso, Andrea, Ciani, Elisabetta, De Filippis, Bianca

“…Introduction CDKL5 deficiency disorder (CDD) is a rare neurodevelopmental condition, primarily affecting girls for which no cure currently exists. Neuronal…”
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