Search Results - "Mottershead, David"

Bone morphogenetic protein 15 in the pro-mature complex form enhances bovine oocyte developmental competence by Sudiman, Jaqueline, Sutton-McDowall, Melanie L, Ritter, Lesley J, White, Melissa A, Mottershead, David G, Thompson, Jeremy G, Gilchrist, Robert B

“…Developmental competence of in vitro matured (IVM) oocytes needs to be improved and this can potentially be achieved by adding recombinant bone morphogenetic…”
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Cumulin, an Oocyte-secreted Heterodimer of the Transforming Growth Factor-β Family, Is a Potent Activator of Granulosa Cells and Improves Oocyte Quality by Mottershead, David G., Sugimura, Satoshi, Al-Musawi, Sara L., Li, Jing-Jie, Richani, Dulama, White, Melissa A., Martin, Georgia A., Trotta, Andrew P., Ritter, Lesley J., Shi, Junyan, Mueller, Thomas D., Harrison, Craig A., Gilchrist, Robert B.

“…Growth differentiation factor 9 (GDF9) and bone morphogenetic protein 15 (BMP15) are oocyte-specific growth factors with central roles in mammalian…”
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TGF-β mediates proinflammatory seminal fluid signaling in human cervical epithelial cells by Sharkey, David J, Macpherson, Anne M, Tremellen, Kelton P, Mottershead, David G, Gilchrist, Robert B, Robertson, Sarah A

“…The cervix is central to the female genital tract immune response to pathogens and foreign male Ags introduced at coitus. Seminal fluid profoundly influences…”
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Promotion of EGF receptor signaling improves the quality of low developmental competence oocytes by Sugimura, Satoshi, Ritter, Lesley J., Rose, Ryan D., Thompson, Jeremy G., Smitz, Johan, Mottershead, David G., Gilchrist, Robert B.

“…Oocytes acquire developmental competence with progressive folliculogenesis. Cumulus oocyte complexes (COCs) from small antral follicles have inherent low…”
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Amphiregulin co-operates with bone morphogenetic protein 15 to increase bovine oocyte developmental competence: effects on gap junction-mediated metabolite supply by Sugimura, Satoshi, Ritter, Lesley J., Sutton-McDowall, Melanie L., Mottershead, David G., Thompson, Jeremy G., Gilchrist, Robert B.

“…This study assessed the participation of amphiregulin (AREG) and bone morphogenetic protein 15 (BMP15) during maturation of bovine cumulus-oocyte complexes…”
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Cumulin and FSH Cooperate to Regulate Inhibin B and Activin B Production by Human Granulosa-Lutein Cells In Vitro by Richani, Dulama, Constance, Katherine, Lien, Shelly, Agapiou, David, Stocker, William A, Hedger, Mark P, Ledger, William L, Thompson, Jeremy G, Robertson, David M, Mottershead, David G, Walton, Kelly L, Harrison, Craig A, Gilchrist, Robert B

“…The oocyte-secreted factors bone morphogenetic protein 15 (BMP15) and growth differentiation factor 9 (GDF9) interact functionally, and it is hypothesized that…”
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Signalling pathways mediating specific synergistic interactions between GDF9 and BMP15 by MOTTERSHEAD, David G, RITTER, Lesley J, GILCHRIST, Robert B

“…Growth differentiation factor 9 (GDF9) and bone morphogenetic protein 15 (BMP15) are two proteins selectively expressed in the oocyte which are essential for…”
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Activin B and Activin C Have Opposing Effects on Prostate Cancer Progression and Cell Growth by Reader, Karen L, John-McHaffie, Simon, Zellhuber-McMillan, Sylvia, Jowett, Tim, Mottershead, David G, Cunliffe, Heather E, Gold, Elspeth J

“…Current prognostic and diagnostic tests for prostate cancer are not able to accurately distinguish between aggressive and latent cancer. Members of the…”
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Heparan Sulfate Proteoglycans Regulate Responses to Oocyte Paracrine Signals in Ovarian Follicle Morphogenesis by Watson, Laura N, Mottershead, David G, Dunning, Kylie R, Robker, Rebecca L, Gilchrist, Robert B, Russell, Darryl L

“…In the ovarian follicle, oocyte-secreted factors induce cumulus-specific genes and repress mural granulosa cell specific genes to establish these functionally…”
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Granulosa Cell Conditioned Medium Enhances The Rate of Mouse Oocyte In Vitro Maturation and Embryo Formation by Bahrami, Zeinab, Hatamian, Narges, Talkhabi, Mahmood, Zand, Elnaz, Mottershead, David G, Fathi, Rouhollah

“…Objective: In vitro maturation (IVM) and cryopreservation of oocytes are two important parts of assisted reproductive technology (ART), but their efficacy is…”
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Molecular basis of oocyte-paracrine signalling that promotes granulosa cell proliferation by Gilchrist, Robert B, Ritter, Lesley J, Myllymaa, Samu, Kaivo-Oja, Noora, Dragovic, Rebecca A, Hickey, Theresa E, Ritvos, Olli, Mottershead, David G

“…Oocytes regulate follicle growth by secreting paracrine growth factors that act on neighbouring granulosa cells (GCs). Those factors identified to date are…”
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Effect of cumulin and super-GDF9 in standard and biphasic mouse IVM by Akin, Nazli, Richani, Dulama, Liao, Xiuhua, Zhao, Yiqing, Herta, Anamaria-Cristina, Billooye, Katy, Stocker, William A., Mottershead, David G., Harrison, Craig A., Smitz, Johan, Anckaert, Ellen, Gilchrist, Robert B.

“…Purpose In vitro maturation (IVM) is a technology that generates mature oocytes following culture of immature cumulus-oocyte complexes (COC) in vitro. IVM is…”
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Smad signalling in the ovary by Kaivo-oja, Noora, Jeffery, Luke A, Ritvos, Olli, Mottershead, David G

“…It has now been a decade since the first discovery of the intracellular Smad proteins, the downstream signalling molecules of one of the most important growth…”
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Seminal fluid factors regulate activin A and follistatin synthesis in female cervical epithelial cells by Sharkey, David J., Schjenken, John E., Mottershead, David G., Robertson, Sarah A.

“…Seminal fluid induces pro-inflammatory cytokines and elicits an inflammation-like response in the cervix. Here, Affymetrix microarray and qPCR was utilised to…”
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Growth differentiation factor 9 signaling requires ERK1/2 activity in mouse granulosa and cumulus cells by Sasseville, Maxime, Ritter, Lesley J, Nguyen, Thao M, Liu, Fang, Mottershead, David G, Russell, Darryl L, Gilchrist, Robert B

“…Ovarian folliculogenesis is driven by the combined action of endocrine cues and paracrine factors. The oocyte secretes powerful mitogens, such as growth…”
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Metabolic Differences in Bovine Cumulus-Oocyte Complexes Matured In Vitro in the Presence or Absence of Follicle-Stimulating Hormone and Bone Morphogenetic Protein 15 by SUTTON-MCDOWALL, Melanie L, MOTTERSHEAD, David G, GARDNER, David K, GILCHRIST, Robert B, THOMPSON, Jeremy G

“…Bidirectional communication between cumulus cells and the oocyte is necessary to achieve oocyte developmental competence. The aim of the present study was to…”
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A Covalently Dimerized Recombinant Human Bone Morphogenetic Protein-15 Variant Identifies Bone Morphogenetic Protein Receptor Type 1B as a Key Cell Surface Receptor on Ovarian Granulosa Cells by Pulkki, Minna M, Mottershead, David G, Pasternack, Arja H, Muggalla, Pranuthi, Ludlow, Helen, van Dinther, Maarten, Myllymaa, Samu, Koli, Katri, ten Dijke, Peter, Laitinen, Mika, Ritvos, Olli

“…Genetic studies have identified bone morphogenetic protein-15 (BMP15) as an essential regulator of female fertility in humans and in sheep. Oocyte-derived…”
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Redox and anti-oxidant state within cattle oocytes following in vitro maturation with bone morphogenetic protein 15 and follicle stimulating hormone by Sutton-McDowall, Melanie L., Purdey, Malcolm, Brown, Hannah M., Abell, Andrew D., Mottershead, David G., Cetica, Pablo D., Dalvit, Gabriel C., Goldys, Ewa M., Gilchrist, Robert B., Gardner, David K., Thompson, Jeremy G.

“…SUMMARY The developmental competence of cumulus oocyte complexes (COCs) can be increased during in vitro oocyte maturation with the addition of exogenous…”
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Modifications of Human Growth Differentiation Factor 9 to Improve the Generation of Embryos From Low Competence Oocytes by Li, Jing-Jie, Sugimura, Satoshi, Mueller, Thomas D, White, Melissa A, Martin, Georgia A, Ritter, Lesley J, Liang, Xiao-Yan, Gilchrist, Robert B, Mottershead, David G

“…Growth differentiation factor 9 (GDF9) is an oocyte-derived growth factor that plays a critical role in ovarian folliculogenesis and oocyte developmental…”
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Growth Differentiation Factor-9 Signaling Is Mediated by the Type I Receptor, Activin Receptor-Like Kinase 5 by Mazerbourg, Sabine, Klein, Cynthia, Roh, Jaesook, Kaivo-Oja, Noora, Mottershead, David G, Korchynskyi, Olexander, Ritvos, Olli, Hsueh, Aaron J. W

“…Growth differentiation factor-9 (GDF-9) is an oocyte-derived growth factor and a member of the TGF-β superfamily that includes TGF-β, activin, and bone…”
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