Search Results - "Motta, Juliana M"
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A low-anticoagulant heparin suppresses metastatic dissemination through the inhibition of tumor cell-platelets association
Published in Biomedicine & pharmacotherapy (01-02-2024)“…Metastasis is the leading cause of cancer-related deaths. Despite this relevance, there is no specific therapy targeting metastasis. The interaction of the…”
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Tunicate Heparan Sulfate Enriched in 2-Sulfated β-Glucuronic Acid: Structure, Anticoagulant Activity, and Inhibitory Effect on the Binding of Human Colon Adenocarcinoma Cells to Immobilized P-Selectin
Published in Marine drugs (12-06-2019)“…Heparin or highly sulfated heparan sulfate (HS) has been described in different invertebrates. In ascidians (Chordata-Tunicata), these glycosaminoglycans occur…”
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Metal ions and the extracellular matrix in tumor migration
Published in The FEBS journal (01-08-2019)“…In this review, we explore the roles of divalent metal ions in structure and function within the extracellular matrix (ECM), specifically, their interaction…”
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Direct antitumoral effects of sulfated fucans isolated from echinoderms: a possible role of neuropilin-1/β1 integrin endocytosis and focal adhesion kinase degradation
Published in Glycobiology (Oxford) (29-10-2023)“…Abstract Hypercoagulability, a major complication of metastatic cancers, has usually been treated with heparins from natural sources, or with their synthetic…”
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HS2ST1‐dependent signaling pathways determine breast cancer cell viability, matrix interactions, and invasive behavior
Published in Cancer science (01-08-2020)“…Heparan sulfate proteoglycans (HSPGs) act as signaling co‐receptors by interaction of their sulfated glycosaminoglycan chains with numerous signaling…”
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Non-Anticoagulant Heparan Sulfate from the Ascidian Phallusia nigra Prevents Colon Carcinoma Metastasis in Mice by Disrupting Platelet-Tumor Cell Interaction
Published in Cancers (26-05-2020)“…Although metastasis is the primary cause of death in patients with malignant solid tumors, efficient anti-metastatic therapies are not clinically available…”
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Direct anti-tumoral effects of sulfated fucans isolated from echinoderms: a possible role of neuropilin-1/β1 integrin endocytosis and focal adhesion kinase (FAK) degradation
Published in Glycobiology (Oxford) (08-06-2023)“…Hypercoagulability, a major complication of metastatic cancers, has usually been treated with heparins from natural sources, or with their synthetic…”
Get full text
Journal Article