Search Results - "Motoyama, Yukio"

The analgesic effect profile of FR122047, a selective cyclooxygenase-1 inhibitor, in chemical nociceptive models by Ochi, Takehiro, Motoyama, Yukio, Goto, Toshio

“…The pharmacological profile of the analgesic agent, 1-[(4,5-bis(4-methoxyphenyl)-2-thiazoyl)carbonyl]-4-methylpiperazine hydrochloride (FR122047), was…”
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In vitro antiplatelet profile of FR171113, a novel non-peptide thrombin receptor antagonist by Kato, Yasuko, Kita, Yasuhiro, Nishio, Mie, Hirasawa, Yoshimi, Ito, Kiyotaka, Yamanaka, Toshio, Motoyama, Yukio, Seki, Jiro

“…Synthetic peptides (5 to 14 amino acids), identical in sequence to the new amino-terminus of the thrombin receptor generated following cleavage by thrombin,…”
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Possible inhibitory mechanism of FK506 (tacrolimus hydrate) ointment for atopic dermatitis based on animal models by Sengoku, Takanori, Morita, Kyoko, Sakuma, Shozo, Motoyama, Yukio, Goto, Toshio

“…The effects of FK506 (tacrolimus hydrate) ointment on cutaneous allergic reactions in mice and rats were investigated. FK506 ointment showed significant…”
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Synthesis and Biological Activity of 1-Phenylsulfonyl-4-Phenylsulfonylaminopyrrolidine Derivatives as Thromboxane A 2 Receptor Antagonists by Marusawa, Hiroshi, Setoi, Hiroyuki, Sawada, Akihiko, Kuroda, Akio, Seki, Jiro, Motoyama, Yukio, Tanaka, Hirokazu

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synthesis and biological activity of 4-methyl-3,5-dioxane derivatives as thromboxane a2 receptor antagonists by Marusawa, Hiroshi, Setoi, Hiroyuki, Kuroda, Akio, Sawada, Akihiko, Seki, Jiro, Motoyama, Yukio, Tanaka, Hirokazu

“…The synthesis and biological activity of novel 4-methyl-3,5-dioxane analogues are described. All compounds were produced through modification of the…”
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Antiplatelet Agents Based on Cyclooxygenase Inhibition without Ulcerogenesis. Evaluation and Synthesis of 4,5-Bis(4-methoxyphenyl)-2-substituted-thiazoles by Tanaka, Akito, Sakai, Hiroyoshi, Motoyama, Yukio, Ishikawa, Takatoshi, Takasugi, Hisashi

“…The syntheses, biological evaluations, and structure-activity relationships of a series of 4,5-bis-(4-methoxyphenyl)-2-substituted-thiazoles as potent…”
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Comparison of the Antithrombotic Effects of FK633, GPIIb/IIIa Antagonist, and Aspirin in a Guinea Pig Thrombosis Model by Aoki, Toshiaki, Cox, Dermot, Senzaki, Kayoko, Seki, Jiro, Tanaka, Akito, Takasugi, Hisashi, Motoyama, Yukio

“…Antiplatelet and antithrombotic effects of FK633 (a GPIIb/IIIa antagonist) and aspirin were compared. FK633 at 0.32 mg/kg i.v. or aspirin at 10 mg/kg i.v…”
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Augmentation of the inhibitory effect of FK480, a CCK-A receptor antagonist, on pancreatic exocrine secretion by achlorhydria by KUNO, M, SOGABE, H, ITO, H, MATSUO, T, SATOH, Y, MOTOYAMA, Y, TANAKA, H

“…The effect of intraluminal acid and cholecystokinin (CCK) receptor blockade on the pancreatic secretory response was examined in rats. Blockade of gastric acid…”
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The anti-platelet actions of FR122047, a novel cyclooxygenase inhibitor by Dohi, M, Sakata, Y, Seki, J, Namikawa, Y, Fujisaki, J, Tanaka, A, Takasugi, H, Motoyama, Y, Yoshida, K

“…The anti-platelet actions of 1-[(4,5-bis(4-methoxyphenyl)-2- thiazoyl)carbonyl]-4-methylpiperazine hydrochloride (FR122047) were investigated in vitro and in…”
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Studies on Anti-platelet Agents. IV. A Series of 2-Substituted 4, 5-Bis(4-methoxyphenyl)pyrimidines as Novel Anti-platelet Agents by TANAKA, Akito, MOTOYAMA, Yukio, TAKASUGI, Hisashi

“…The syntheses and structure-activity relationships of a series of 2-substituted 4, 5-bis(4-methoxyphenyl)pyrimidines, designed on the basis of structural…”
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Studies on Anti-platelet Agents. II. Synthesis and Platelet-Inhibitory Activity of 5-Methyl-4-(3-pyridyl)-2-(substituted Benzimidazol-5-yl)imidazoles by TANAKA, Akito, ITO, Kiyotaka, NISHINO, Shigetaka, MOTOYAMA, Yukio, TAKASUGI, Hisashi

“…A series of 5-methyl-4-(3-pyridyl)-2-(substituted benzimidazol-5-yl)imidazole derivatives was synthesized and tested for anti-platelet and vasodilatory…”
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Studies on Anti-platelet Agents. V. Synthesis and Structur-Activity Relationship of 3-Substituted 5,6-Bis(4-methoxyphenyl)-1,2,4-triazines by TANAKA, Akito, SAKAI, Hiroyoshi, ISHIKAWA, Takatoshi, MOTOYAMA, Yukio, TAKASUGI, Hisashi

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Pentamidine: a non-peptide GPIIb/IIIa antagonist--in vitro studies on platelets from humans and other species by Cox, D, Motoyama, Y, Seki, J, Aoki, T, Dohi, M, Yoshida, K

“…In this paper we show that the non-peptide anti-parasite agent pentamidine is a broad spectrum anti-platelet agent with an IC50 of 1.1 microM in ADP-induced…”
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The Profile of FR140423, a Novel Anti-inflammatory Compound, in Yeast-Induced Rat Hyperalgesia by Ochi, Takehiro, Fujii, Takashi, Motoyama, Yukio, Goto, Toshio

“…The mechanism of action of FR140423 (3-(difluoromethyl)-l-(4-methoxyphenyl)-5-[4-(methylsulfinyl)phenyl]pyrazole), a novel anti-inflammatory compound, in a rat…”
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Synthesis and biological activity of 1-phenylsulfonyl-4-phenylsulfonylaminopyrrolidine derivatives as thromboxane A2 receptor antagonists by MARUSAWA, Hiroshi, SETOI, Hiroyuki, SAWADA, Akihiko, KURODA, Akio, SEKI, Jiro, MOTOYAMA, Yukio, TANAKA, Hirokazu

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The Profile of FR140423, a Novel Anti-inflammatory Compound, in Yeast-Induced Rat Hyperalgesia by Ochi, Takehiro, Fujii, Takashi, Motoyama, Yukio, Goto, Toshio

“…The mechanism of action of FR140423 (3-(difluoromethyl)-1-(4-methoxyphenyl)-5-[4-(methylsulfinyl)phenyl]pyrazole), a novel anti-inflammatory compound, in a rat…”
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The pharmacology of the integrins by Cox, D, Aoki, T, Seki, J, Motoyama, Y, Yoshida, K

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Synthesis and biological activity of 1-phenylsulfonyl-4-phenylsulfonylaminopyrrolidine derivatives as thromboxane a(2) receptor antagonists by Marusawa, Hiroshi, Setoi, Hiroyuki, Sawada, Akihiko, Kuroda, Akio, Seki, Jiro, Motoyama, Yukio, Tanaka, Hirokazu

“…The synthesis and biological activity of novel 1-phenylsulfonyl-4- phenylsulfonylaminopyrrolidine analogues are described. All compounds were produced through…”
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Comparison of two genetically non-insulin dependent diabetic mice, db/db and ob/ob mouse by Nakajima, Satoko, Hirosumi, Jiro, Kodama, Hiroshi, Mutoh, Seitaro, Motoyama, Yukio, Shimomura, Kyoichi

“…Although db/db and ob/ob mice share common features such as hyperglycemia, hyperinsulinemia and obesity, they have etiological differences. It is important to…”
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Studies on Antiplatelet Agents. I. Synthesis and Platelet Inhibitory Activity of 5-Alkyl-2-aryl-4-pyridylimidazoles by TANAKA, Akito, ITO, Kiyotaka, NISHINO, Shigetake, MOTOYAMA, Yukio, TAKASUGI, Hisashi

“…5-Alkyl-2-aryl-4-pyridylimidazoles were synthesized and tested in rat ex vivo platelet aggregation studies. Among these compounds,…”
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