Search Results - "Motola, Daniel"

A TALEN Genome-Editing System for Generating Human Stem Cell-Based Disease Models by Ding, Qiurong, Lee, Youn-Kyoung, Schaefer, Esperance A.K., Peters, Derek T., Veres, Adrian, Kim, Kevin, Kuperwasser, Nicolas, Motola, Daniel L., Meissner, Torsten B., Hendriks, William T., Trevisan, Marta, Gupta, Rajat M., Moisan, Annie, Banks, Eric, Friesen, Max, Schinzel, Robert T., Xia, Fang, Tang, Alexander, Xia, Yulei, Figueroa, Emmanuel, Wann, Amy, Ahfeldt, Tim, Daheron, Laurence, Zhang, Feng, Rubin, Lee L., Peng, Lee F., Chung, Raymond T., Musunuru, Kiran, Cowan, Chad A.

“…Transcription activator-like effector nucleases (TALENs) are a new class of engineered nucleases that are easier to design to cleave at desired sites in a…”
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Efficacy and safety of pembrolizumab monotherapy in patients with advanced thyroid cancer in the phase 2 KEYNOTE‐158 study by Oh, Do‐Youn, Algazi, Alain, Capdevila, Jaume, Longo, Federico, Miller, Wilson, Chun Bing, Jerry Tan, Bonilla, Carlos Eduardo, Chung, Hyun Cheol, Guren, Tormod K., Lin, Chia‐Chi, Motola‐Kuba, Daniel, Shah, Manisha, Hadoux, Julien, Yao, Lili, Jin, Fan, Norwood, Kevin, Lebellec, Loïc

“…Background The authors report results from the thyroid carcinoma cohort of the multicohort phase 2 KEYNOTE‐158 study (NCT02628067), which evaluated…”
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Hepatic Injury in Nonalcoholic Steatohepatitis Contributes to Altered Intestinal Permeability by Luther, Jay, Garber, John J, Khalili, Hamed, Dave, Maneesh, Bale, Shyam Sundhar, Jindal, Rohit, Motola, Daniel L, Luther, Sanjana, Bohr, Stefan, Jeoung, Soung Won, Deshpande, Vikram, Singh, Gurminder, Turner, Jerrold R, Yarmush, Martin L, Chung, Raymond T, Patel, Suraj J

“…Background & Aims Emerging data suggest that changes in intestinal permeability and increased gut microbial translocation contribute to the inflammatory…”
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bile acid-like steroid modulates Caenorhabditis elegans lifespan through nuclear receptor signaling by Gerisch, Birgit, Rottiers, Veerle, Li, Dongling, Motola, Daniel L, Cummins, Carolyn L, Lehrach, Hans, Mangelsdorf, David J, Antebi, Adam

“…Broad aspects of Caenorhabditis elegans life history, including larval developmental timing, arrest at the dauer diapause, and longevity, are regulated by the…”
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Long noncoding RNAs expressed in human hepatic stellate cells form networks with extracellular matrix proteins by Zhou, Chan, York, Samuel R, Chen, Jennifer Y, Pondick, Joshua V, Motola, Daniel L, Chung, Raymond T, Mullen, Alan C

“…Hepatic fibrosis is the underlying cause of cirrhosis and liver failure in nearly every form of chronic liver disease, and hepatic stellate cells (HSCs) are…”
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Hormonal Control of C. elegans Dauer Formation and Life Span by a Rieske-like Oxygenase by Rottiers, Veerle, Motola, Daniel L., Gerisch, Birgit, Cummins, Carolyn L., Nishiwaki, Kiyoji, Mangelsdorf, David J., Antebi, Adam

“…C. elegans diapause, gonadal outgrowth, and life span are regulated by a lipophilic hormone, which serves as a ligand to the nuclear hormone receptor DAF-12. A…”
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Identification of Ligands for DAF-12 that Govern Dauer Formation and Reproduction in C. elegans by Motola, Daniel L., Cummins, Carolyn L., Rottiers, Veerle, Sharma, Kamalesh K., Li, Tingting, Li, Yong, Suino-Powell, Kelly, Xu, H. Eric, Auchus, Richard J., Antebi, Adam, Mangelsdorf, David J.

“…In response to environmental and dietary cues, the C. elegans orphan nuclear receptor, DAF-12, regulates dauer diapause, reproductive development, fat…”
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Identification of the nuclear receptor DAF-12 as a therapeutic target in parasitic nematodes by Wang, Zhu, Zhou, X. Edward, Motola, Daniel L, Gao, Xin, Suino-Powell, Kelly, Conneely, Aoife, Ogata, Craig, Sharma, Kamalesh K, Auchus, Richard J, Lok, James B, Hawdon, John M, Kliewer, Steven A, Xu, H. Eric, Mangelsdorf, David J

“…Nematode parasitism is a worldwide health problem resulting in malnutrition and morbidity in over 1 billion people. The molecular mechanisms governing…”
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The Rieske oxygenase DAF‐36 functions as a cholesterol 7‐desaturase in steroidogenic pathways governing longevity by Wollam, Joshua, Magomedova, Lilia, Magner, Daniel B., Shen, Yidong, Rottiers, Veerle, Motola, Daniel L., Mangelsdorf, David J., Cummins, Carolyn L., Antebi, Adam

“…Summary Bile acids are cholesterol‐derived signaling molecules that regulate mammalian metabolism through sterol‐sensing nuclear receptor transcription…”
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Tricyclic Antidepressants Promote Ceramide Accumulation to Regulate Collagen Production in Human Hepatic Stellate Cells by Chen, Jennifer Y., Newcomb, Benjamin, Zhou, Chan, Pondick, Joshua V., Ghoshal, Sarani, York, Samuel R., Motola, Daniel L., Coant, Nicolas, Yi, Jae Kyo, Mao, Cungui, Tanabe, Kenneth K., Bronova, Irina, Berdyshev, Evgeny V., Fuchs, Bryan C., Hannun, Yusuf, Chung, Raymond T., Mullen, Alan C.

“…Activation of hepatic stellate cells (HSCs) in response to injury is a key step in hepatic fibrosis, and is characterized by trans-differentiation of quiescent…”
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Gastrointestinal symptoms and weight loss in cancer patients receiving chemotherapy by Sánchez-Lara, Karla, Ugalde-Morales, Emilio, Motola-Kuba, Daniel, Green, Dan

“…Cancer patients receiving chemotherapy have a high risk of malnutrition secondary to the disease and treatment, and 40–80 % of cancer patients suffer from…”
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Structural Conservation of Ligand Binding Reveals a Bile Acid-like Signaling Pathway in Nematodes by Zhi, Xiaoyong, Zhou, X. Edward, Melcher, Karsten, Motola, Daniel L., Gelmedin, Verena, Hawdon, John, Kliewer, Steven A., Mangelsdorf, David J., Xu, H. Eric

“…Bile acid-like molecules named dafachronic acids (DAs) control the dauer formation program in Caenorhabditis elegans through the nuclear receptor DAF-12. This…”
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Influence of taste disorders on dietary behaviors in cancer patients under chemotherapy by Sánchez-Lara, Karla, Sosa-Sánchez, Ricardo, Green-Renner, Dan, Rodríguez, Cindy, Laviano, Alessandro, Motola-Kuba, Daniel, Arrieta, Oscar

“…To determine the relationship between energy and nutrient consumption with chemosensory changes in cancer patients under chemotherapy. We carried out a…”
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Apolipoprotein B100 is required for hepatitis C infectivity and Mipomersen inhibits hepatitis C by Schaefer, Esperance A K, Meixiong, James, Mark, Christina, Deik, Amy, Motola, Daniel L, Fusco, Dahlene, Yang, Andrew, Brisac, Cynthia, Salloum, Shadi, Lin, Wenyu, Clish, Clary B, Peng, Lee F, Chung, Raymond T

“…AIM To characterize the role of apolipoprotein B100(apoB 100) in hepatitis C viral(HCV) infection. METHODS In this study, we utilize a gene editing tool,…”
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Oligomerization and Regulated Proteolytic Processing of Angiopoietin-like Protein 4 by Ge, Hongfei, Yang, Guoqing, Huang, Lu, Motola, Daniel L., Pourbahrami, Tiffany, Li, Cai

“…Angiopoietin-like protein 4 (Angptl4) is a recently identified circulating protein expressed primarily in adipose tissue and liver. Also known as peroxisome…”
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Noninvasive Biomarkers of Liver Fibrosis: Clinical Applications and Future Directions by Motola, Daniel L., Caravan, Peter, Chung, Raymond T., Fuchs, Bryan C.

“…Chronic liver disease is a significant cause of morbidity and mortality worldwide. Current strategies for assessing prognosis and treatment rely on accurate…”
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Synthesis and Activity of Dafachronic Acid Ligands for the C. elegans DAF-12 Nuclear Hormone Receptor by Sharma, Kamalesh K, Wang, Zhu, Motola, Daniel L, Cummins, Carolyn L, Mangelsdorf, David J, Auchus, Richard J

“…The nuclear hormone receptor DAF-12 from Caenorhabditis elegans is activated by dafachronic acids, which derive from sterols upon oxidation by DAF-9, a…”
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Bone metastases as the initial presentation of hepatocellular carcinoma. Two case reports and a literature review by Ruiz-Morales, Jose M, Dorantes-Heredia, Rita, Chable-Montero, Fredy, Vazquez-Manjarrez, Sara, Méndez-Sánchez, Nahum, Motola-Kuba, Daniel, M.D

“…AbstractHepatocellular carcinoma (HCC) is the most common primary tumor of the liver and is the fifth most common cancer in the world; its incidence has been…”
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PD-L1 expression complements CALGB prognostic scoring system in malignant pleural mesothelioma by Avilés-Salas, Alejandro, Cabrera-Miranda, Luis, Hernández-Pedro, Norma, Vargas-Lías, Diana Sofía, Samtani, Suraj, Muñoz-Montaño, Wendy, Motola-Kuba, Daniel, Corrales-Rodríguez, Luis, Martín, Claudio, Cardona, Andrés F, Palomares-Palomares, Cittim B, Arrieta, Oscar

“…Programmed death ligand-1 (PD-L1) expression is a predictive biomarker in patients with lung cancer, but its role in malignant pleural mesothelioma (MPM)…”
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Giant Benign Mammary Phyllodes Tumor: Report of a Case and Review of the Literature by Fernández-Ferreira, Ricardo, Arroyave-Ramírez, Andrés, Motola-Kuba, Daniel, Alvarado-Luna, Gabriela, Mackinney-Novelo, Ileana, Segura-Rivera, Román

“…Phyllodes tumor of the breast is an infrequently encountered fibroepithelial neoplasm, which accounts for 0.3–1% of all tumors. Few case reports have described…”
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