Search Results - "Motojima, Masaru"

Foxc1 and Foxc2 are indispensable for the maintenance of nephron and stromal progenitors in the developing kidney by Motojima, Masaru, Tanaka, Masayuki, Kume, Tsutomu

“…ABSTRACT Nephron development proceeds with reciprocal interactions among three layers: nephron progenitors (NPs), ureteric buds and stromal progenitors (SPs)…”
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Global polysome analysis of normal and injured podocytes by Okabe, Masahiro, Motojima, Masaru, Miyazaki, Yoichi, Pastan, Ira, Yokoo, Takashi, Matsusaka, Taiji

“…Podocyte injury is a key event for progressive renal failure. We have previously established a mouse model of inducible podocyte injury (NEP25) that…”
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Indirect podocyte injury manifested in a partial podocytectomy mouse model by Okabe, Masahiro, Yamamoto, Kazuyoshi, Miyazaki, Yoichi, Motojima, Masaru, Ohtsuka, Masato, Pastan, Ira, Yokoo, Takashi, Matsusaka, Taiji

“…In progressive glomerular diseases, segmental podocyte injury often expands, leading to global glomerulosclerosis by unclear mechanisms. To study the expansion…”
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Targeted insertion of conditional expression cassettes into the mouse genome using the modified i-PITT by Miura, Hiromi, Nakamura, Ayaka, Kurosaki, Aki, Kotani, Ai, Motojima, Masaru, Tanaka, Keiko, Kakuta, Shigeru, Ogiwara, Sanae, Ohmi, Yuhsuke, Komaba, Hirotaka, Schilit, Samantha L P, Morton, Cynthia C, Gurumurthy, Channabasavaiah B, Ohtsuka, Masato

“…Transgenic (Tg) mice are widely used in biomedical research, and they are typically generated by injecting transgenic DNA cassettes into pronuclei of one-cell…”
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Super-Enhancer-Associated Transcription Factors Maintain Transcriptional Regulation in Mature Podocytes by Yang, Jingping, Zhang, Difei, Motojima, Masaru, Kume, Tsutomu, Hou, Qing, Pan, Yu, Duan, Aiping, Zhang, Mingchao, Jiang, Song, Hou, Jinhua, Shi, Jingsong, Qin, Zhaohui, Liu, Zhihong

“…Transcriptional programs control cell fate, and identifying their components is critical for understanding diseases caused by cell lesion, such as…”
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Oral activated charcoal adsorbent (AST-120) ameliorates extent and instability of atherosclerosis accelerated by kidney disease in apolipoprotein E-deficient mice by Yamamoto, Suguru, Zuo, Yiqin, Ma, Ji, Yancey, Patricia G., Hunley, Tracy E., Motojima, Masaru, Fogo, Agnes B., Linton, MacRae F., Fazio, Sergio, Ichikawa, Iekuni, Kon, Valentina

“…Background. Accelerated atherosclerosis and increased cardiovascular events are not only more common in chronic kidney disease (CKD) but are more resistant to…”
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Characterization of Kidney and Skeleton Phenotypes of Mice Double Heterozygous for Foxc1 and Foxc2 by Motojima, Masaru, Tanimoto, Sho, Ohtsuka, Masato, Matsusaka, Taiji, Kume, Tsutomu, Abe, Koichiro

“…Foxc1 and Foxc2 play key roles in mouse development. Foxc1 mutant mice develop duplex kidneys with double ureters, and lack calvarial and sternal bones. Foxc2…”
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Conditional knockout of Foxc2 gene in kidney: efficient generation of conditional alleles of single-exon gene by double-selection system by Motojima, Masaru, Ogiwara, Sanae, Matsusaka, Taiji, Kim, Sang Yong, Sagawa, Nobuho, Abe, Koichiro, Ohtsuka, Masato

“…Foxc2 is a single-exon gene and a key regulator in development of multiple organs, including kidney. To avoid embryonic lethality of conventional Foxc2…”
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Administration of oral charcoal adsorbent (AST-120) suppresses low-turnover bone progression in uraemic rats by Iwasaki, Yoshiko, Yamato, Hideyuki, Nii-Kono, Tomoko, Fujieda, Ayako, Uchida, Motoyuki, Hosokawa, Atsuko, Motojima, Masaru, Fukagawa, Masafumi

“…Background. Using a rat model of renal failure with normal parathyroid hormone levels, we had demonstrated previously that bone formation decreased depending…”
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Renal Dysfunction Potentiates Foam Cell Formation by Repressing ABCA1 by Zuo, Yiqin, Yancey, Patricia, Castro, Iris, Khan, Wasif, Motojima, Masaru, Ichikawa, Iekuni, Fogo, Agnes B, Linton, MacRae F, Fazio, Sergio, Kon, Valentina

“…OBJECTIVE—Patients with chronic kidney disease (CKD) have the highest risk for atherosclerotic cardiovascular disease (CVD). Current interventions have been…”
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Uraemic toxins induce proximal tubular injury via organic anion transporter 1‐mediated uptake by Motojima, Masaru, Hosokawa, Atsuko, Yamato, Hideyuki, Muraki, Takamura, Yoshioka, Toshimasa

“…A direct effect of uraemic toxins in promoting progression of chronic renal disease has not been established. In this study, we investigated the toxic effects…”
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Angiotensin inhibition decreases progression of advanced atherosclerosis and stabilizes established atherosclerotic plaques by SUGANUMA, Eisuke, BABAEV, Vladimir R, MOTOJIMA, Masaru, YIQIN ZUO, AYABE, Nobuhiko, FOGO, Agnes B, ICHIKAWA, Lekuni, LINTON, Macrae F, FAZIO, Sergio, KON, Valentina

“…Although increased extracellular matrix (ECM) is pathogenic in a variety of chronic tissue injuries, reduced and/or disrupted ECM may be detrimental in…”
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Uremic toxins overload accelerates renal damage in a rat model of chronic renal failure by Satoh, Masami, Hayashi, Hideo, Watanabe, Maki, Ueda, Kyoko, Yamato, Hideyuki, Yoshioka, Toshimasa, Motojima, Masaru

“…Uremic toxins have been suggested to promote progression of chronic renal failure by damaging tubular cells. Previous in vitro studies have indicated that some…”
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Foxc1 and Foxc2 are necessary to maintain glomerular podocytes by Motojima, Masaru, Kume, Tsutomu, Matsusaka, Taiji

“…Foxc1 and Foxc2 (Foxc1/2) are transcription factors involved in many biological processes. In adult kidneys, expression of Foxc1/2 is confined to the…”
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Uremic toxin and bone metabolism by Iwasaki, Yoshiko, Yamato, Hideyuki, Nii-Kono, Tomoko, Fujieda, Ayako, Uchida, Motoyuki, Hosokawa, Atsuko, Motojima, Masaru, Fukagawa, Masafumi

“…Patients with end-stage renal disease (ESRD) develop various kinds of abnormalities in bone and mineral metabolism, widely known as renal osteodystrophy (ROD)…”
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Role of c-Jun NH2-terminal kinase in G-protein-coupled receptor agonist-induced cardiac plasminogen activator inhibitor-1 expression by Omura, Takashi, Yoshiyama, Minoru, Matsumoto, Ryo, Kusuyama, Takanori, Enomoto, Soichiro, Nishiya, Daisuke, Izumi, Yasukatsu, Kim, Shokei, Ichijo, Hidenori, Motojima, Masaru, Akioka, Kaname, Iwao, Hiroshi, Takeuchi, Kazuhide, Yoshikawa, Junichi

“…Plasminogen activator inhibitor-1 (PAI-1) has been implicated as a contributing risk factor for cardiovascular disease. However, little is known about…”
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Expression of nephrin, a podocyte specific protein, depends on MafB and ligands of nuclear receptors by Motojima, Masaru, Kinomura, Masaru, Matsusaka, Taiji, Ichikawa, Iekuni

“…Abstract only…”
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Uremic toxins of organic anions up-regulate PAI-1 expression by induction of NF-κB and free radical in proximal tubular cells by Motojima, Masaru, Hosokawa, Atsuko, Yamato, Hideyuki, Muraki, Takamura, Yoshioka, Toshimasa

“…Uremic toxins of organic anions up-regulate PAI-1 expression by induction of NF-κB and free radical in proximal tubular cells. Uremic toxins have been…”
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Role for “uremic toxin” in the progressive loss of intact nephrons in chronic renal failure by Motojima, Masaru, Nishijima, Fuyuhiko, Ikoma, Masaaki, Kawamura, Tetsuya, Yoshioka, Toshimasa, Fogo, Agnes B., Sakai, Tadasu, Ichikawa, Iekuni

“…Role for “uremic toxin” in the progressive loss of intact nephrons in chronic renal failure. We studied the effect on the progression of glomerular sclerosis…”
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Fibrinogen that appears in Bowman's space of proteinuric kidneys in vivo activates podocyte Toll-like receptors 2 and 4 in vitro by Motojima, Masaru, Matsusaka, Taiji, Kon, Valentina, Ichikawa, Iekuni

“…Composition of nonselective proteinuria includes several endogenous ligands of Toll-like receptors (TLRs) not normally present in Bowman's space, thus raising…”
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