Search Results - "MotlÍk, Jan"

Mapping of the secretome of primary isolates of mammalian cells, stem cells and derived cell lines by Skalnikova, Helena, Motlik, Jan, Gadher, Suresh Jivan, Kovarova, Hana

“…Within a mammalian organism, the interaction among cells both at short and long distances is mediated by soluble factors released by cells into the…”
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AAV5-miHTT Gene Therapy Demonstrates Broad Distribution and Strong Human Mutant Huntingtin Lowering in a Huntington’s Disease Minipig Model by Evers, Melvin M., Miniarikova, Jana, Juhas, Stefan, Vallès, Astrid, Bohuslavova, Bozena, Juhasova, Jana, Skalnikova, Helena Kupcova, Vodicka, Petr, Valekova, Ivona, Brouwers, Cynthia, Blits, Bas, Lubelski, Jacek, Kovarova, Hana, Ellederova, Zdenka, van Deventer, Sander J., Petry, Harald, Motlik, Jan, Konstantinova, Pavlina

“…Huntington’s disease (HD) is a fatal neurodegenerative disorder caused by a CAG trinucleotide repeat expansion in the huntingtin gene. Previously, we showed…”
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Longitudinal study revealing motor, cognitive and behavioral decline in a transgenic minipig model of Huntington's disease by Baxa, Monika, Levinska, Bozena, Skrivankova, Monika, Pokorny, Matous, Juhasova, Jana, Klima, Jiri, Klempir, Jiri, Motlı K, Jan, Juhas, Stefan, Ellederova, Zdenka

“…Huntington's disease (HD) is an inherited devastating neurodegenerative disease with no known cure to date. Several therapeutic treatments for HD are in…”
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New aspects of galectin functionality in nuclei of cultured bone marrow stromal and epidermal cells: biotinylated galectins as tool to detect specific binding sites by Purkrábková, Tereza, Smetana, Karel, Dvořánková, Barbora, Holíková, Zuzana, Böck, Corina, Lensch, Martin, André, Sabine, Pytlík, Robert, Liu, Fu-Tong, Klíma, Jiří, Smetana, Karel, Motlík, Jan, Gabius, Hans-Joachim

“…Nuclear presence of galectins suggests a role of these endogenous lectins in the regulation of transcription, pre-mRNA splicing and transport processes…”
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Multiple requirements of PLK1 during mouse oocyte maturation by Solc, Petr, Kitajima, Tomoya S, Yoshida, Shuhei, Brzakova, Adela, Kaido, Masako, Baran, Vladimir, Mayer, Alexandra, Samalova, Pavlina, Motlik, Jan, Ellenberg, Jan

“…Polo-like kinase 1 (PLK1) orchestrates multiple events of cell division. Although PLK1 function has been intensively studied in centriole-containing and…”
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The role of RanGTP gradient in vertebrate oocyte maturation by Kaláb, Petr, Solc, Petr, Motlík, Jan

“…The maturation of vertebrate oocyte into haploid gamete, the egg, consists of two specialized asymmetric cell divisions with no intervening S-phase. Ran GTPase…”
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The Miniature Pig as an Animal Model in Biomedical Research by VODIČKA, PETR, SMETANA JR, KAREL, DVOŘÁNKOVÁ, BARBORA, EMERICK, TERESA, XU, YINGZHI Z., OUREDNIK, JITKA, OUREDNIK, VÁCLAV, MOTLÍK, JAN

“…: Crucial prerequisites for the development of safe preclinical protocols in biomedical research are suitable animal models that would allow for human‐related…”
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A cell-free nanofiber composite scaffold regenerated osteochondral defects in miniature pigs by Filová, Eva, Rampichová, Michala, Litvinec, Andrej, Držík, Milan, Míčková, Andrea, Buzgo, Matej, Košťáková, Eva, Martinová, Lenka, Usvald, Dušan, Prosecká, Eva, Uhlík, Jiří, Motlík, Jan, Vajner, Luděk, Amler, Evžen

“…The aim of the study was to evaluate the effect of a cell-free hyaluronate/type I collagen/fibrin composite scaffold containing polyvinyl alcohol (PVA)…”
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Transgenic minipig model of Huntington's disease exhibiting gradually progressing neurodegeneration by Ardan, Taras, Baxa, Monika, Levinská, Božena, Sedláčková, Miroslava, Nguyen, The Duong, Klíma, Jiří, Juhás, Štefan, Juhásová, Jana, Šmatlíková, Petra, Vochozková, Petra, Motlík, Jan, Ellederová, Zdenka

“…Recently developed therapeutic approaches for the treatment of Huntington's disease (HD) require preclinical testing in large animal models. The minipig is a…”
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Deterioration of mitochondrial bioenergetics and ultrastructure impairment in skeletal muscle of a transgenic minipig model in the early stages of Huntington's disease by Rodinova, Marie, Krizova, Jana, Stufkova, Hana, Bohuslavova, Bozena, Askeland, Georgina, Dosoudilova, Zaneta, Juhas, Stefan, Juhasova, Jana, Ellederova, Zdenka, Zeman, Jiri, Eide, Lars, Motlik, Jan, Hansikova, Hana

“…Skeletal muscle wasting and atrophy is one of the more severe clinical impairments resulting from the progression of Huntington's disease (HD). Mitochondrial…”
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Remodeling of donor nuclei, DNA-synthesis, and ploidy of bovine cumulus cell nuclear transfer embryos: Effect of activation protocol by Alberio, Ramiro, Brero, Alessandro, Motlík, Jan, Cremer, Thomas, Wolf, Eckhard, Zakhartchenko, Valeri

“…The purpose of this study was to investigate the effects of two activation protocols on nuclear remodeling, DNA synthesis during the first cell cycle,…”
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Advantages of nanofibrous membranes for culturing of primary RPE cells compared to commercial scaffolds by Tichotová, Lucie, Studenovska, Hana, Petrovski, Goran, Popelka, Štěpán, Nemesh, Yaroslav, Sedláčková, Miroslava, Drutovič, Saskia, Rohiwal, Sonali, Jendelová, Pavla, Erceg, Slaven, Brymová, Anna, Artero‐Castro, Ana, Lytvynchuk, Lyubomyr, Straňák, Zbyněk, Ellederová, Zdeňka, Motlík, Jan, Ardan, Taras

“…ABSTRACT Purpose Dysfunction of the retinal pigment epithelium (RPE) causes numerous forms of retinal degeneration. RPE replacement is a modern option to save…”
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Mitochondrial Dysfunction in a High Intraocular Pressure-Induced Retinal Ischemia Minipig Model by Pasák, Michael, Vanišová, Marie, Tichotová, Lucie, Křížová, Jana, Ardan, Taras, Nemesh, Yaroslav, Čížková, Jana, Kolesnikova, Anastasiia, Nyshchuk, Ruslan, Josifovska, Natasha, Lytvynchuk, Lyubomyr, Kolko, Miriam, Motlík, Jan, Petrovski, Goran, Hansíková, Hana

“…Retinal ischemia (RI) and progressive neuronal death are sight-threatening conditions. Mitochondrial (mt) dysfunction and fusion/fission processes have been…”
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Behavioral testing of minipigs transgenic for the Huntington gene-A three-year observational study by Schuldenzucker, Verena, Schubert, Robin, Muratori, Lisa M, Freisfeld, Frauke, Rieke, Lorena, Matheis, Tamara, Schramke, Sarah, Motlik, Jan, Kemper, Nicole, Radespiel, Ute, Reilmann, Ralf

“…Large animal models of Huntington's disease (HD) may increase the reliability of translating preclinical findings to humans. Long live expectancy offers…”
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Early disruption of photoreceptor cell architecture and loss of vision in a humanized pig model of usher syndromes by Grotz, Sophia, Schäfer, Jessica, Wunderlich, Kirsten A, Ellederova, Zdenka, Auch, Hannah, Bähr, Andrea, Runa‐Vochozkova, Petra, Fadl, Janet, Arnold, Vanessa, Ardan, Taras, Veith, Miroslav, Santamaria, Gianluca, Dhom, Georg, Hitzl, Wolfgang, Kessler, Barbara, Eckardt, Christian, Klein, Joshua, Brymova, Anna, Linnert, Joshua, Kurome, Mayuko, Zakharchenko, Valeri, Fischer, Andrea, Blutke, Andreas, Döring, Anna, Suchankova, Stepanka, Popelar, Jiri, Rodríguez‐Bocanegra, Eduardo, Dlugaiczyk, Julia, Straka, Hans, May‐Simera, Helen, Wang, Weiwei, Laugwitz, Karl‐Ludwig, Vandenberghe, Luk H, Wolf, Eckhard, Nagel‐Wolfrum, Kerstin, Peters, Tobias, Motlik, Jan, Fischer, M Dominik, Wolfrum, Uwe, Klymiuk, Nikolai

“…Usher syndrome (USH) is the most common form of monogenic deaf‐blindness. Loss of vision is untreatable and there are no suitable animal models for testing…”
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Serum proteomic analysis of melanoma patients with immunohistochemical profiling of primary melanomas and cultured cells: Pilot study by Kučera, Jan, Strnadová, Karolína, Dvořánková, Barbora, Lacina, Lukáš, Krajsová, Ivana, Štork, Jiří, Kovářová, Hana, Skalníková, Helena Kupcová, Vodička, Petr, Motlík, Jan, Dundr, Pavel, Smetana, Jr, Karel, Kodet, Ondřej

“…The steadily increasing incidence of malignant melanoma (MM) and its aggressive behaviour makes this tumour an attractive cancer research topic. The tumour…”
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AKT (protein kinase B) is implicated in meiotic maturation of porcine oocytes by Kalous, Jaroslav, Kubelka, Michal, Šolc, Petr, Šušor, Andrej, Motlík, Jan

“…The aim of this study was to investigate the involvement of the serine/threonine protein kinase AKT (also called protein kinase B) in the control of meiosis of…”
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Subretinal Implantation of Human Primary RPE Cells Cultured on Nanofibrous Membranes in Minipigs by Lytvynchuk, Lyubomyr, Ebbert, Annabelle, Studenovska, Hana, Nagymihály, Richárd, Josifovska, Natasha, Rais, David, Popelka, Štěpán, Tichotová, Lucie, Nemesh, Yaroslav, Čížková, Jana, Juhásová, Jana, Juhás, Štefan, Jendelová, Pavla, Franeková, Janka, Kozak, Igor, Erceg, Slaven, Straňák, Zbynek, Müller, Brigitte, Ellederová, Zdenka, Motlík, Jan, Stieger, Knut, Ardan, Taras, Petrovski, Goran

“…The development of primary human retinal pigmented epithelium (hRPE) for clinical transplantation purposes on biodegradable scaffolds is indispensable. We…”
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Chronic spinal compression model in minipigs: a systematic behavioral, qualitative, and quantitative neuropathological study by Navarro, Roman, Juhas, Stefan, Keshavarzi, Sassan, Juhasova, Jana, Motlik, Jan, Johe, Karl, Marsala, Silvia, Scadeng, Miriam, Lazar, Peter, Tomori, Zoltan, Schulteis, Gery, Beattie, Michael, Ciacci, Joseph D, Marsala, Martin

“…The goal of the present study was to develop a porcine spinal cord injury (SCI) model, and to describe the neurological outcome and characterize the…”
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Upregulation of IL-6, IL-8 and CXCL-1 production in dermal fibroblasts by normal/malignant epithelial cells in vitro: Immunohistochemical and transcriptomic analyses by Kolář, Michal, Szabo, Pavol, Dvořánková, Barbora, Lacina, Lukáš, Gabius, Hans-Joachim, Strnad, Hynek, Šáchová, Jana, Vlček, Čestmír, Plzák, Jan, Chovanec, Martin, Čada, Zdeněk, Betka, Jan, Fík, Zdeněk, Pačes, Jan, Kovářová, Hana, Motlík, Jan, Jarkovská, Karla, Smetana Jr, Karel

“…Background information Considering an analogy between wound healing and tumour progression, we studied chemokine and cytokine transcription and expression in…”
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