Functions, mechanisms, and clinical applications of lncRNA LINC00857 in cancer pathogenesis

Functions, mechanisms, and clinical applications of lncRNA LINC00857 in cancer pathogenesis

Emerging data indicated that long noncoding RNAs (lncRNAs) are crucial players in the biological processes via regulating epigenetics, transcription, and protein translation. A novel lncRNA, LINC00857, was indicated to upregulate in several types of cancer. In addition, LINC00857 was functionally re...

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Published in:Human cell : official journal of Human Cell Research Society Vol. 36; no. 5; pp. 1656 - 1671
Main Authors: Aldayyeni, Hussein, Hjazi, Ahmed, Shahab, Sana, Gupta, Jitendra, Alsaab, Hashem O., Motea, Yaseen Hasan, alazbjee, Adeeb Abdulally Abdulhussien, Romero-Parra, Rosario Mireya, Obaid, Rasha Fadhel, Hussien, Beneen M., Hosseini-Fard, Seyed Reza
Format: Journal Article
Language:English
Published: Singapore Springer Nature Singapore 01-09-2023
Springer Nature B.V
Subjects:
Apoptosis
Biomedical and Life Sciences
Cancer
Cell Biology
Cell cycle
Epigenetics
Gynecology
Life Sciences
Medical research
Molecular modelling
Non-coding RNA
Oncology
Reproductive Medicine
Review Article
Stem Cells
Surgery
Therapeutic applications
LncRNA
LINC00857
Oncogene
Cancer
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Summary:Emerging data indicated that long noncoding RNAs (lncRNAs) are crucial players in the biological processes via regulating epigenetics, transcription, and protein translation. A novel lncRNA, LINC00857, was indicated to upregulate in several types of cancer. In addition, LINC00857 was functionally related to the modulation of the cancer-linked behaviors, including invasion, migration, proliferation, epithelial–mesenchymal transition (EMT), cell cycle, and apoptosis. The importance of LINC00857 in cancer onset and development proposed that LINC00857 has major importance in the cancer progression and may be considered as a novel prognostic/diagnostic biomarker as well as a treatment target. Here, we retrospectively investigate the available progress in biomedical research investigating the functions of LINC00857 in cancer, focusing on finding the molecular mechanisms affecting various cancer-related behaviors and exploring its clinical applications.
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ObjectType-Review-1
ISSN:1749-0774
0914-7470
1749-0774
DOI:10.1007/s13577-023-00936-0