Mesenchymal stem cells and immunomodulation: current status and future prospects

Mesenchymal stem cells and immunomodulation: current status and future prospects

The unique immunomodulatory properties of mesenchymal stem cells (MSCs) make them an invaluable cell type for the repair of tissue/ organ damage caused by chronic inflammation or autoimmune disorders. Although they hold great promise in the treatment of immune disorders such as graft versus host dis...

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Bibliographic Details
Published in:Cell death & disease Vol. 7; no. 1; p. e2062
Main Authors: Gao, F, Chiu, S M, Motan, D A L, Zhang, Z, Chen, L, Ji, H-L, Tse, H-F, Fu, Q-L, Lian, Q
Format: Journal Article
Language:English
Published: London Nature Publishing Group UK 01-01-2016
Springer Nature B.V
Nature Publishing Group
Subjects:
631/532/2074
631/61/51/1844
692/699/249
692/700/565/251
Antibodies
Autoimmune diseases
Biochemistry
Biomedical and Life Sciences
Cell Biology
Cell Culture
Humans
Immune system
Immunology
Immunomodulation - immunology
Inflammatory diseases
Life Sciences
Mesenchymal Stromal Cells - immunology
Review
Stem cells
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Summary:The unique immunomodulatory properties of mesenchymal stem cells (MSCs) make them an invaluable cell type for the repair of tissue/ organ damage caused by chronic inflammation or autoimmune disorders. Although they hold great promise in the treatment of immune disorders such as graft versus host disease (GvHD) and allergic disorders, there remain many challenges to overcome before their widespread clinical application. An understanding of the biological properties of MSCs will clarify the mechanisms of MSC-based transplantation for immunomodulation. In this review, we summarize the preclinical and clinical studies of MSCs from different adult tissues, discuss the current hurdles to their use and propose the future development of pluripotent stem cell-derived MSCs as an approach to immunomodulation therapy.
Bibliography:These authors contributed equally to this work.
ISSN:2041-4889
2041-4889
DOI:10.1038/cddis.2015.327