Subcutaneous tissue responses to three endodontic irrigants: a comparative study

This study aimed to compare the subcutaneous tissue responses to MTAD (mixture of a tetracycline isomer, an acid, and a detergent), 17% EDTA, and 2.6% NaOCl. Thirty-six Wistar albino rats were used for this study. Test solutions were injected subcutaneously into predetermined areas on the animal dor...

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Bibliographic Details
Published in:	Iranian endodontic journal Vol. 7; no. 3; pp. 144 - 148
Main Authors:	Ashofteh Yazdi, Kazem, Sabeti, Mohammad, Motahhary, Pooriya, Kolahdouzan, Alireza, Shayesteh, Mohsen, Shokouhinejad, Noushin
Format:	Journal Article
Language:	English
Published:	Iran Iranian Center for Endodontic Research 2012 Iranian Association of Endodontists; Iranian Center for Endodontic Research
Subjects:	EDTA Inflammation MTAD Original Sodium hypochlorite Subcutaneous Tissue Toxicity Sodium hypochlorite Subcutaneous Tissue Inflammation EDTA Toxicity MTAD
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Summary:	This study aimed to compare the subcutaneous tissue responses to MTAD (mixture of a tetracycline isomer, an acid, and a detergent), 17% EDTA, and 2.6% NaOCl. Thirty-six Wistar albino rats were used for this study. Test solutions were injected subcutaneously into predetermined areas on the animal dorsum. The rats were then randomly divided into three groups of twelve each and sacrificed at 2 hours, 2 days, and 2 weeks. The severity of inflammation induced by each irrigant at different time intervals was assessed histologically. The data were analyzed using Kruskal-Wallis and Friedman tests. The difference in severity of inflammatory reactions induced by tested irrigants at the different time intervals was statically significant (P<0.05). There was no significant difference between the severity of inflammation induced by MTAD and 2.6% NaOCl at the various time intervals (P>0.05). Subcutaneous tissue responses to MTAD were not different from those observed in 17% EDTA specimens at 2-hour and 2-day intervals (P>0.05). Under the conditions of this study, MTAD has the same toxicity as 2.6% NaOCl.
ISSN:	1735-7497 2008-2746