Search Results - "Mostowski, HS"

Production of IL-10 by Human Natural Killer Cells Stimulated with IL-2 and/or IL-12 by Mehrotra, Priti T, Donnelly, Raymond P, Wong, Susan, Kanegane, Hirokazu, Geremew, Amare, Mostowski, Howard S, Furuke, Keizo, Siegel, Jay P, Bloom, Eda T

“…Human NK cell activity can be augmented in vitro by stimulation with IL-2 or IL-12, both of which also induce the production of IFN-gamma, TNF-alpha, and…”
Get full text

Fas Ligand Induction in Human NK Cells Is Regulated by Redox Through a Calcineurin-Nuclear Factors of Activated T Cell-Dependent Pathway by Furuke, Keizo, Shiraishi, Mitsuhiro, Mostowski, Howard S, Bloom, Eda T

“…Fas ligand (FasL) on cytotoxic lymphocytes is important for mediating apoptosis of activated lymphocytes and other target cells. We have reported that NK cell…”
Get full text

Effects of IL-12 on the generation of cytotoxic activity in human CD8+ T lymphocytes by Mehrotra, PT, Wu, D, Crim, JA, Mostowski, HS, Siegel, JP

“…We have studied the effects of human rIL-12 on the proliferation and generation of cytotoxic activity in human CTL precursors. Purified human blood CD8+ T…”
Get full text

Target Cell-Induced Apoptosis of Interleukin-2–Activated Human Natural Killer Cells: Roles of Cell Surface Molecules and Intracellular Events by Yamauchi, Akira, Taga, Kazuyuki, Mostowski, Howard S., Bloom, Eda T.

“…We previously reported that natural killer (NK)-sensitive target cells, K562, kill interleukin-2-stimulated (lymphokine-activated killer [LAK]) but not…”
Get full text

Underutilization of the V kappa 10C gene in the B cell repertoire is due to the loss of productive VJ rearrangements during B cell development by Fitzsimmons, S P, Clark, K J, Mostowski, H S, Shapiro, M A

“…The V kappa10 family of murine light chain Ig genes is composed of three members, two of which (V kappa 10A and V kappa 10B) are well used. V kappa 10C, the…”
Get full text

Expression of a Constitutive Mutant of Iron Regulatory Protein 1 Abolishes Iron Homeostasis in Mammalian Cells (∗) by DeRusso, Patricia A., Philpott, Caroline C., Iwai, Kazuhiro, Mostowski, Howard S., Klausner, Richard D., Rouault, Tracey A.

“…Iron regulatory proteins (IRPs) are iron-sensing proteins that bind to RNA stem-loop sequences known as iron-responsive elements (IREs) when cells are depleted…”
Get full text

Cytokine-induced enhancement of ICAM-1 expression results in increased vulnerability of tumor cells to monocyte-mediated lysis by Webb, DS, Mostowski, HS, Gerrard, TL

“…Pretreatment of the human melanoma cell line, A375, and the human colon carcinoma cell line, HT-29, with certain cytokines was found to increase the…”
Get full text

Regulation of human cytotoxic T lymphocyte development by IL-7 by Hickman, CJ, Crim, JA, Mostowski, HS, Siegel, JP

“…The effects of IL-7 on the generation of human CTL in alloantigen-, virus-, and lectin-stimulated systems were examined. Addition of IL-7 at the onset of…”
Get full text

IL-4 and granulocyte-macrophage colony-stimulating factor selectively increase HLA-DR and HLA-DP antigens but not HLA-DQ antigens on human monocytes by Gerrard, TL, Dyer, DR, Mostowski, HS

“…A number of cytokines were tested for their ability to modulate HLA-DR Ag expression on normal human monocytes. IL-4, granulocyte-macrophage (GM)-CSF as well…”
Get full text

Characterization of a monoclonal antibody (4F2) that binds to human monocytes and to a subset of activated lymphocytes by Haynes, B F, Hemler, M E, Mann, D L, Eisenbarth, G S, Shelhamer, J, Mostowski, H S, Thomas, C A, Strominger, J L, Fauci, A S

Get full text

Mitogenic stimulation of human lymphocytes mediated by a cell surface elastase by Packard, Beverly Z., Mostowski, Howard S., Komoriya, Akira

“…A ca. 45-kDa protein which was recently identified and purified to homogeneity from a solid tumor cell line as a T-cell mitogen was found to have significant…”
Get full text

A bioassay for the measurement of human interleukin-4 by Siegel, J P, Mostowski, H S

“…We have developed a bioassay for human IL-4 based upon its ability to upregulate CD23 (low affinity IgE receptor) expression. Ramos, a B lymphocyte line…”
Get more information

IL-12 administered in vivo to young and aged mice. Discrepancy between the effects on tumor growth in vivo and cytotoxic T lymphocyte generation ex vivo: dependence on IFN-γ by Horvath-Arcidiacono, Judith A., Mostowski, Howard S., Bloom, Eda T.

“…Because IL-12 restores allogeneic cytotoxic T lymphocyte (CTL) activity by T cells of aged mice in vitro, we initially assessed whether IL-12 could overcome…”
Get full text

Characterization of a Monoclonal Antibody that Defines an Immunoregulatory T Cell Subset for Immunoglobulin Synthesis in Humans by Haynes, Barton F., Mann, Dean L., Hemler, Martin E., Schroer, Joyce A., Shelhamer, James H., Eisenbarth, George S., Strominger, Jack L., Thomas, Charles A., Mostowski, Howard S., Fauci, Anthony S.

“…This study characterizes a monoclonal antibody (3A1), and partially characterizes the cell surface antigen and the functional peripheral blood T cell subset…”
Get full text

Does the age-related change in CD44-defined T-cell subsets have functional significance for cytotoxic T lymphocyte generation? by Bloom, E T, Mostowski, H S, Horvath, J A

“…CD44 or Pgp-1 is a transmembrane leukocyte adhesion-related glycoprotein which is often expressed in greater density on the membranes of memory T lymphocytes…”
Get more information