Search Results - "Mosteiro, Carlos S"
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Action of Obestatin in Skeletal Muscle Repair: Stem Cell Expansion, Muscle Growth, and Microenvironment Remodeling
Published in Molecular therapy (01-06-2015)“…The development of therapeutic strategies for skeletal muscle diseases, such as physical injuries and myopathies, depends on the knowledge of regulatory…”
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2
Obestatin signalling counteracts glucocorticoid‐induced skeletal muscle atrophy via NEDD4/KLF15 axis
Published in Journal of cachexia, sarcopenia and muscle (01-04-2021)“…Background A therapeutic approach for the treatment of glucocorticoid‐induced skeletal muscle atrophy should be based on the knowledge of the molecular…”
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3
The SHP-1 protein tyrosine phosphatase negatively modulates Akt signaling in the ghrelin/GHSR1a system
Published in Molecular biology of the cell (01-11-2011)“…The aim of the present study was to identify the signaling mechanism(s) responsible for the modulation of growth hormone secretagogue receptor type 1a…”
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4
The role of the obestatin/GPR39 system in human gastric adenocarcinomas
Published in Oncotarget (02-02-2016)“…Obestatin, a 23-amino acid peptide encoded by the ghrelin gene, and the GPR39 receptor were reported to be involved in the control of mitogenesis of gastric…”
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5
Improvement of Duchenne muscular dystrophy phenotype following obestatin treatment
Published in Journal of cachexia, sarcopenia and muscle (01-12-2018)“…Background This study was performed to test the therapeutic potential of obestatin, an autocrine anabolic factor regulating skeletal muscle repair, to…”
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6
The NMR structure of human obestatin in membrane-like environments: insights into the structure-bioactivity relationship of obestatin
Published in PloS one (04-10-2012)“…The quest for therapeutic applications of obestatin involves, as a first step, the determination of its 3D solution structure and the relationship between this…”
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7
Preproghrelin expression is a key target for insulin action on adipogenesis
Published in Journal of endocrinology (01-08-2011)“…This study aimed to investigate the role of preproghrelin-derived peptides in adipogenesis. Immunocytochemical analysis of 3T3-L1 adipocyte cells showed…”
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An energy restriction‐based weight loss intervention is able to reverse the effects of obesity on the expression of liver tumor‐promoting genes
Published in The FASEB journal (01-02-2020)“…The epidemiological evidence regarding the association of obesity with liver disease and possibly hepatocellular carcinoma highlights the need for…”
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Obestatin Increases the Regenerative Capacity of Human Myoblasts Transplanted Intramuscularly in an Immunodeficient Mouse Model
Published in Molecular therapy (04-10-2017)“…Although cell-based therapy is considered a promising method aiming at treating different muscular disorders, little clinical benefit has been reported. One of…”
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10
β-Arrestin scaffolds and signaling elements essential for the obestatin/GPR39 system that determine the myogenic program in human myoblast cells
Published in Cellular and molecular life sciences : CMLS (01-02-2016)“…Obestatin/GPR39 signaling stimulates skeletal muscle repair by inducing the expansion of satellite stem cells as well as myofiber hypertrophy. Here, we…”
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The Obestatin/G Protein-Coupled Receptor 39 (GPR39) System in Human Stomach: Its Role on Pepsinogen I Secretion
Published in Gastroenterology (New York, N.Y. 1943) (01-04-2017)Get full text
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12
The Obestatin/GPR39 System Is Up-regulated by Muscle Injury and Functions as an Autocrine Regenerative System
Published in The Journal of biological chemistry (02-11-2012)“…The maintenance and repair of skeletal muscle are attributable to an elaborate interaction between extrinsic and intrinsic regulatory signals that regulate the…”
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13
Obestatin controls the ubiquitin–proteasome and autophagy–lysosome systems in glucocorticoid‐induced muscle cell atrophy
Published in Journal of cachexia, sarcopenia and muscle (01-12-2017)“…Background Many pathological states characterized by muscle atrophy are associated with an increase in circulating glucocorticoids and poor patient prognosis,…”
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14
β-Arrestin signal complex plays a critical role in adipose differentiation
Published in The international journal of biochemistry & cell biology (01-07-2013)“…β-Arrestins were identified as scaffold-proteins that have the capacity to desensitize G protein-coupled receptors. However, it has been found that β-arrestins…”
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15
Obestatin increases the regenerative capacity of human myoblasts transplanted intra-muscularly in an immunodeficient mouse model
Published in Molecular therapy (01-10-2017)“…Although cell-based therapy is considered a promising method aiming at treating different muscular disorders, little clinical benefit has been reported. One of…”
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16
Tu1592 - The Obestatin/G Protein-Coupled Receptor 39 (GPR39) System in Human Stomach: Its Role on Pepsinogen I Secretion
Published in Gastroenterology (New York, N.Y. 1943) (01-04-2017)Get full text
Journal Article -
17
[beta]-Arrestin scaffolds and signaling elements essential for the obestatin/GPR39 system that determine the myogenic program in human myoblast cells
Published in Cellular and molecular life sciences : CMLS (01-02-2016)“…Obestatin/GPR39 signaling stimulates skeletal muscle repair by inducing the expansion of satellite stem cells as well as myofiber hypertrophy. Here, we…”
Get full text
Journal Article