The interplay of p38 MAPK signaling and mitochondrial metabolism, a dynamic target in cancer and pathological contexts

[Display omitted] Mitochondria play a crucial role in cellular metabolism and bioenergetics, orchestrating various cellular processes, including energy production, metabolism, adaptation to stress, and redox balance. Besides, mitochondria regulate cellular metabolic homeostasis through coordination...

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Published in:	Biochemical pharmacology Vol. 225; p. 116307
Main Authors:	Sarg, Nadin H., Zaher, Dana M., Abu Jayab, Nour N., Mostafa, Salma H., Ismail, Hussein H., Omar, Hany A.
Format:	Journal Article
Language:	English
Published:	England Elsevier Inc 01-07-2024
Subjects:	Aerobic glycolysis Animals Cancer Cellular stress Energy homeostasis Energy Metabolism - physiology Humans MAP Kinase Signaling System - physiology Mitochondria - metabolism Mitochondrial functions Neoplasms - drug therapy Neoplasms - metabolism Neoplasms - pathology P38 MAPK p38 Mitogen-Activated Protein Kinases - metabolism NPC CaMK PFKFB3 APS IFI6 UCP1 YAP GBE WAT HK2 Aβ MSCs OA MB MK2 ISCs β3-A AD GLUT PKM2 ASK1 PKA T2D P38 MAPK PKC PGC-1α IL-1β MKK EMT ER Mitochondrial functions ECM RA KATP MMP Cellular stress PDAC PD BAT Energy homeostasis Aerobic glycolysis Cancer
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Summary:	[Display omitted] Mitochondria play a crucial role in cellular metabolism and bioenergetics, orchestrating various cellular processes, including energy production, metabolism, adaptation to stress, and redox balance. Besides, mitochondria regulate cellular metabolic homeostasis through coordination with multiple signaling pathways. Importantly, the p38 mitogen-activated protein kinase (MAPK) signaling pathway is a key player in the intricate communication with mitochondria, influencing various functions. This review explores the multifaced interaction between the mitochondria and p38 MAPK signaling and the consequent impact on metabolic alterations. Overall, the p38 MAPK pathway governs the activities of key mitochondrial proteins, which are involved in mitochondrial biogenesis, oxidative phosphorylation, thermogenesis, and iron homeostasis. Additionally, p38 MAPK contributes to the regulation of mitochondrial responses to oxidative stress and apoptosis induced by cancer therapies or natural substances by coordinating with other pathways responsible for energy homeostasis. Therefore, dysregulation of these interconnected pathways can lead to various pathologies characterized by aberrant metabolism. Consequently, gaining a deeper understanding of the interaction between mitochondria and the p38 MAPK pathway and their implications presents exciting forecasts for novel therapeutic interventions in cancer and other disorders characterized by metabolic dysregulation.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23
ISSN:	0006-2952 1873-2968 1873-2968
DOI:	10.1016/j.bcp.2024.116307