Synaptic BMAL1 phosphorylation controls circadian hippocampal plasticity

The time of day strongly influences adaptive behaviors like long-term memory, but the correlating synaptic and molecular mechanisms remain unclear. The circadian clock comprises a canonical transcription-translation feedback loop (TTFL) strictly dependent on the BMAL1 transcription factor. We report...

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Bibliographic Details
Published in:	Science advances Vol. 9; no. 43; p. eadj1010
Main Authors:	Barone, Ilaria, Gilette, Nicole M, Hawks-Mayer, Hannah, Handy, Jonathan, Zhang, Kevin J, Chifamba, Fortunate F, Mostafa, Engie, Johnson-Venkatesh, Erin M, Sun, Yan, Gibson, Jennifer M, Rotenberg, Alexander, Umemori, Hisashi, Tsai, Peter T, Lipton, Jonathan O
Format:	Journal Article
Language:	English
Published:	United States American Association for the Advancement of Science 27-10-2023
Subjects:	ARNTL Transcription Factors - genetics Circadian Clocks Circadian Rhythm - physiology Hippocampus - metabolism Molecular Biology Neuroscience Phosphorylation SciAdv r-articles
Online Access:	Get full text
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Summary:	The time of day strongly influences adaptive behaviors like long-term memory, but the correlating synaptic and molecular mechanisms remain unclear. The circadian clock comprises a canonical transcription-translation feedback loop (TTFL) strictly dependent on the BMAL1 transcription factor. We report that BMAL1 rhythmically localizes to hippocampal synapses in a manner dependent on its phosphorylation at Ser [pBMAL1(S42)]. pBMAL1(S42) regulates the autophosphorylation of synaptic CaMKIIα and circadian rhythms of CaMKIIα-dependent molecular interactions and LTP but not global rest/activity behavior. Therefore, our results suggest a model in which repurposing of the clock protein BMAL1 to synapses locally gates the circadian timing of plasticity.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 These authors contributed equally to this work.
ISSN:	2375-2548 2375-2548
DOI:	10.1126/sciadv.adj1010