Search Results - "Mossoba, Miriam E"

In vitro toxicological assessment of free 3-MCPD and select 3-MCPD esters on human proximal tubule HK-2 cells by Mossoba, Miriam E., Mapa, Mapa S. T., Araujo, Magali, Zhao, Yang, Flannery, Brenna, Flynn, Thomas, Sprando, Jessica, Wiesenfeld, Paddy, Sprando, Robert L.

“…Chloropropanols are chemical contaminants that can be formed during industrial processing of foods, such as lipids used in commercially available infant and…”
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Long-term in vitro effects of exposing the human HK-2 proximal tubule cell line to 3-monochloropropane-1,2-diol by Mossoba, Miriam E., Mapa, Mapa S.T., Araujo, Magali, Zhao, Yang, Flannery, Brenna, Flynn, Thomas, Sprando, Jessica, Wiesenfeld, Paddy, Sprando, Robert L.

“…3-Monochloropropane-1,2-diol (3-MCPD) is a food processing contaminant in the U.S. food supply, detected in infant formula. In vivo rodent model studies have…”
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Evaluation of transporter expression in HK-2 cells after exposure to free and ester-bound 3-MCPD by Mossoba, Miriam E., Mapa, Mapa S.T., Sprando, Jessica, Araujo, Magali, Sprando, Robert L.

“…[Display omitted] •3-Monochloropropane-1,2-diol (3-MCPD) and its fatty acid esters have the potential to induce nephrotoxicity.•We used an in vitro cellular…”
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Comparative Impact of Trastuzumab and Cyclophosphamide on HER-2―Positive Human Breast Cancer Xenografts by FRANCIA, Giulio, SHAN MAN, LEE, Chyan-Jang, LEE, Christina R, PING XU, MOSSOBA, Miriam E, EMMENEGGER, Urban, MEDIN, Jeffrey A, KERBEL, Robert S

“…Metronomic chemotherapy is a minimally toxic and frequently effective new treatment strategy that is beginning to show promising phase II clinical trial…”
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A method to dissolve 3-MCPD mono- and di-esters in aqueous cell culture media by Mapa, Mapa S.T., Araujo, Magali, Zhao, Yang, Flynn, Thomas, Sprando, Jessica, Wiesenfeld, Paddy, Sprando, Robert L., Mossoba, Miriam E.

“…[Display omitted] Fatty acid esters of 3-monochloropropane-1,2-diol (3-MCPD) are chemical contaminants found in a wide range of edible oils that are thermally…”
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Evaluation of “Dream Herb,” Calea zacatechichi, for Nephrotoxicity Using Human Kidney Proximal Tubule Cells by Wiesenfeld, Paddy, Vohra, Sanah, Flynn, Thomas J., Mossoba, Miriam E., Sprando, Robert L.

“…A recent surge in the use of dietary supplements, including herbal remedies, necessitates investigations into their safety profiles. “Dream herb,” Calea…”
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Comparison of diglycolic acid exposure to human proximal tubule cells in vitro and rat kidneys in vivo by Mossoba, Miriam E, Vohra, Sanah, Toomer, Howard, Pugh-Bishop, Shelia, Keltner, Zachary, Topping, Vanessa, Black, Thomas, Olejnik, Nicholas, Depina, Ana, Belgrave, Kathleen, Sprando, Jessica, Njorge, Joyce, Flynn, Thomas J, Wiesenfeld, Paddy L, Sprando, Robert L

“…Diglycolic acid (DGA) is present in trace amounts in our food supply and is classified as an indirect food additive linked with the primary GRAS food additive…”
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Potent induction of B- and T-cell immunity against human carcinoembryonic antigen-expressing tumors in human carcinoembryonic antigen transgenic mice mediated by direct lentivector injection by Loisel-Meyer, Severine, Felizardo, Tania, Mariotti, Jacopo, Mossoba, Miriam E, Foley, Jason E, Kammerer, Robert, Mizue, Nobuo, Keefe, Robert, McCart, J Andrea, Zimmermann, Wolfgang, Dropulic, Boro, Fowler, Daniel H, Medin, Jeffrey A

“…The applicability of immunotherapy would be dramatically broadened to a greater number of recipients if direct “off-the-shelf” products could be engineered to…”
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In vitro exposure of Adhatoda zeylanica to human renal cells lacks acute toxicity by Mossoba, Miriam E, Flynn, Thomas J, Vohra, Sanah N, Wiesenfeld, Paddy L, Sprando, Robert L

“…is a dietary supplement ingredient present in several types of dietary supplements, including weight loss, respiratory relief, and immune regulating products…”
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In Vitro to In Vivo Concordance of Toxicity Using the Human Proximal Tubule Cell Line HK-2 by Mossoba, Miriam E., Sprando, Robert L.

“…The renal proximal tubule cell line, human kidney 2 (HK-2), recapitulates many of the functional cellular and molecular characteristics of differentiated…”
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Assessment of intestinal absorption/metabolism of 3-chloro-1,2-propanediol (3-MCPD) and three 3-MCPD monoesters by Caco-2 cells by Araujo, Magali, Beekman, Jessica K., Mapa, Mapa S.T., MacMahon, Shaun, Zhao, Yang, Flynn, Thomas J., Flannery, Brenna, Mossoba, Miriam E., Sprando, Robert L.

“…3-chloro-1,2-propanediol (3-MCPD) and 3-MCPD esters are contaminants present in a variety of processed foods, including infant formulas. Toxicological data are…”
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28-day repeated dose response study of diglycolic acid: Renal and hepatic effects by Sprando, Robert L., Mossoba, Miriam E., Black, Thomas, Keltner, Zachary, Vohra, Sanah, Olejnik, Nicholas, Toomer, Howard, Stine, Cynthia, Evans, Eric, Sprando, Jessica L., Ferguson, Martine

“…The acute oral toxicity of diglycolic acid (DGA) was evaluated. Groups of female rats (n = 8 rats/group) received 28 consecutive daily single doses of 0.3,…”
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A novel isotope dilution UHPLC-ESI-MS/MS method for the quantification of 3-monochloropropane-1,2-diol in Caco-2 cell transport and receiving buffers by Zhao, Yang, Araujo, Magali, Flynn, Thomas J., Mapa, Mapa S.T., Mossoba, Miriam E., Sprando, Robert L.

“…A routine, selective and sensitive ultra-high performance liquid chromatography-electrospray ionisation tandem triple quadrupole mass spectrometry…”
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Genetically Engineered Human Kidney Cells for Real-Time Cytotoxicity Testing In Vitro by Mossoba, Miriam E., Vohra, Sanah N., Bigley, Elmer, Sprando, Jessica, Wiesenfeld, Paddy L.

“…Classic toxicology studies often utilize in vivo animal models. Newer approaches employing in vitro organ-specific cellular models have been developed in…”
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Pentostatin Plus Cyclophosphamide Safely and Effectively Prevents Immunotoxin Immunogenicity in Murine Hosts by MOSSOBA, Miriam E, ONDA, Masanori, TAYLOR, Justin, MASSEY, Paul R, TREADWELL, Shirin, SHARON, Elad, HASSAN, Raffit, PASTAN, Ira, FOWLER, Daniel H

“…The success of immunotoxin therapy of cancer is limited by host production of neutralizing antibodies, which are directed toward the Pseudomonas exotoxin A…”
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Diglycolic acid induces HepG2/C3A liver cell toxicity in vitro by Mossoba, Miriam E., Vohra, Sanah, Toomer, Howard, Pugh-Bishop, Shelia, Keltner, Zachary, Topping, Vanessa, Black, Thomas, Olejnik, Nicholas, Depina, Ana, Belgrave, Kathleen, Sprando, Jessica, Flynn, Thomas J., Wiesenfeld, Paddy L., Sprando, Robert L.

“…Carboxymethyl starches are added to food products for thickening or tablet binding/filling purposes. Although they lack toxicity, their synthesis creates the…”
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Human kidney proximal tubule cells are vulnerable to the effects of Rauwolfia serpentina by Mossoba, Miriam E., Flynn, Thomas J., Vohra, Sanah, Wiesenfeld, Paddy L., Sprando, Robert L.

“…Rauwolfia serpentina (or Snake root plant) is a botanical dietary supplement marketed in the USA for maintaining blood pressure. Very few studies have…”
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Phase 2 clinical trial of rapamycin-resistant donor CD4+ Th2/Th1 (T-Rapa) cells after low-intensity allogeneic hematopoietic cell transplantation by Fowler, Daniel H., Mossoba, Miriam E., Steinberg, Seth M., Halverson, David C., Stroncek, David, Khuu, Hahn M., Hakim, Frances T., Castiello, Luciano, Sabatino, Marianna, Leitman, Susan F., Mariotti, Jacopo, Gea-Banacloche, Juan C., Sportes, Claude, Hardy, Nancy M., Hickstein, Dennis D., Pavletic, Steven Z., Rowley, Scott, Goy, Andre, Donato, Michele, Korngold, Robert, Pecora, Andrew, Levine, Bruce L., June, Carl H., Gress, Ronald E., Bishop, Michael R.

“…In experimental models, ex vivo induced T-cell rapamycin resistance occurred independent of T helper 1 (Th1)/T helper 2 (Th2) differentiation and yielded…”
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High-Dose Sirolimus and Immune-Selective Pentostatin plus Cyclophosphamide Conditioning Yields Stable Mixed Chimerism and Insufficient Graft-versus-Tumor Responses by Mossoba, Miriam E, Halverson, David C, Kurlander, Roger, Schuver, Bazetta Blacklock, Carpenter, Ashley, Hansen, Brenna, Steinberg, Seth M, Ali, Syed Abbas, Tageja, Nishant, Hakim, Frances T, Gea-Banacloche, Juan, Sportes, Claude, Hardy, Nancy M, Hickstein, Dennis D, Pavletic, Steven Z, Khuu, Hanh, Sabatini, Marianna, Stroncek, David, Levine, Bruce L, June, Carl H, Mariotti, Jacopo, Rixe, Olivier, Fojo, Antonio Tito, Bishop, Michael R, Gress, Ronald E, Fowler, Daniel H

“…We hypothesized that lymphoid-selective host conditioning and subsequent adoptive transfer of sirolimus-resistant allogeneic T cells (T-Rapa), when combined…”
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Phase I Trial of Adoptive Cell Transfer with Mixed-Profile Type-I/Type-II Allogeneic T Cells for Metastatic Breast Cancer by HARDY, Nancy M, MOSSOBA, Miriam E, LEVINE, Bruce L, JUNE, Carl H, KHUU, Hahn M, CARPENTER, Ashley E, KRUMLAUF, Michael C, DWYER, Andrew J, GRESS, Ronald E, FOWLER, Daniel H, BISHOP, Michael R, STEINBERG, Seth M, FELLOWES, Vicki, YAN, Xiao-Yi, HAKIM, Frances T, BABB, Rebecca R, AVILA, Daniele, GEA-BANACLOCHE, Juan, SPORTES, Claude

“…Metastatic breast cancer (MBC) response to allogeneic lymphocytes requires donor T-cell engraftment and is limited by graft-versus-host disease (GVHD). In…”
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