Search Results - "Mossman, Brooke T"

Innate Immune Activation Through Nalp3 Inflammasome Sensing of Asbestos and Silica by DOSTERT, Catherine, PETRILLI, Virginie, VAN BRUGGEN, Robin, STEELE, Chad, MOSSMAN, Brooke T, TSCHOPP, Jürg

“…The inhalation of airborne pollutants, such as asbestos or silica, is linked to inflammation of the lung, fibrosis, and lung cancer. How the presence of…”
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Pulmonary Endpoints (Lung Carcinomas and Asbestosis) Following Inhalation Exposure to Asbestos by Mossman, Brooke T., Lippmann, Morton, Hesterberg, Thomas W., Kelsey, Karl T., Barchowsky, Aaron, Bonner, James C.

“…Lung carcinomas and pulmonary fibrosis (asbestosis) occur in asbestos workers. Understanding the pathogenesis of these diseases is complicated because of…”
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Silica induces NLRP3 inflammasome activation in human lung epithelial cells by Peeters, Paul M, Perkins, Timothy N, Wouters, Emiel F M, Mossman, Brooke T, Reynaert, Niki L

“…In myeloid cells the inflammasome plays a crucial role in innate immune defenses against pathogen- and danger-associated patterns such as crystalline silica…”
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Oxidants and Signaling by Mitogen-Activated Protein Kinases in Lung Epithelium by Mossman, Brooke T, Lounsbury, Karen M, Reddy, Sekhar P

“…Oxidants in cigarette smoke and generated from asbestos fibers activate mitogen-activated protein kinase (MAPK) signaling cascades in lung epithelial cells in…”
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TNF-α Inhibits Asbestos-Induced Cytotoxicity via a NF-κB-Dependent Pathway, a Possible Mechanism for Asbestos-Induced Oncogenesis by Yang, Haining, Bocchetta, Maurizio, Kroczynska, Barbara, Elmishad, Amira G., Chen, Yuanbin, Liu, Zemin, Bubici, Concetta, Mossman, Brooke T., Pass, Harvey I., Testa, Joseph R., Franzoso, Guido, Carbone, Michele

“…Asbestos is the main cause of human malignant mesothelioma (MM). In vivo, macrophages phagocytize asbestos and, in response, release TNF-α and other cytokines…”
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The NLRP3 inflammasome in pathogenic particle and fibre-associated lung inflammation and diseases by Sayan, Mutlay, Mossman, Brooke T

“…The concept of the inflammasome, a macromolecular complex sensing cell stress or danger signals and initiating inflammation, was first introduced approximately…”
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Mechanisms in the pathogenesis of asbestosis and silicosis by MOSSMAN, B. T, CHURG, A

“…This review will briefly address the clinical and pathologic features of asbestosis and silicosis, and consider the mineralogic features of asbestos and silica…”
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Down-regulation of Manganese-Superoxide Dismutase through Phosphorylation of FOXO3a by Akt in Explanted Vascular Smooth Muscle Cells from Old Rats by Li, Muyao, Chiu, Jen-Fu, Mossman, Brooke T., Fukagawa, Naomi K.

“…Manganese-superoxide dismutase (MnSOD) is one of the major cellular antioxidant defense systems. To study the effect of age on the regulation of MnSOD in the…”
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Myeloperoxidase Deficiency Attenuates Lipopolysaccharide-Induced Acute Lung Inflammation and Subsequent Cytokine and Chemokine Production by Haegens, Astrid, Heeringa, Peter, van Suylen, Robert Jan, Steele, Chad, Aratani, Yasuaki, O'Donoghue, Robert J. J, Mutsaers, Steven E, Mossman, Brooke T, Wouters, Emiel F. M, Vernooy, Juanita H. J

“…Lung neutrophilia is common to a variety of lung diseases. The production of reactive oxygen and nitrogen species during neutrophil oxidative burst has been…”
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Blocking of ERK1 and ERK2 sensitizes human mesothelioma cells to doxorubicin by Shukla, Arti, Hillegass, Jedd M, MacPherson, Maximilian B, Beuschel, Stacie L, Vacek, Pamela M, Pass, Harvey I, Carbone, Michele, Testa, Joseph R, Mossman, Brooke T

“…Malignant mesotheliomas (MM) have a poor prognosis, largely because of their chemoresistance to anti-cancer drugs such as doxorubicin (Dox). Here we show using…”
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Inflammation precedes the development of human malignant mesotheliomas in a SCID mouse xenograft model by Hillegass, Jedd M., Shukla, Arti, Lathrop, Sherrill A., MacPherson, Maximilian B., Beuschel, Stacie L., Butnor, Kelly J., Testa, Joseph R., Pass, Harvey I., Carbone, Michele, Steele, Chad, Mossman, Brooke T.

“…Asbestos fibers cause chronic inflammation that may be critical to the development of malignant mesothelioma (MM). Two human MM cell lines (Hmeso, PPM Mill)…”
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Asbestos modulates thioredoxin-thioredoxin interacting protein interaction to regulate inflammasome activation by Thompson, Joyce K, Westbom, Catherine M, MacPherson, Maximilian B, Mossman, Brooke T, Heintz, Nicholas H, Spiess, Page, Shukla, Arti

“…Asbestos exposure is related to various diseases including asbestosis and malignant mesothelioma (MM). Among the pathogenic mechanisms proposed by which…”
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Osteopontin Modulates Inflammation, Mucin Production, and Gene Expression Signatures After Inhalation of Asbestos in a Murine Model of Fibrosis by Sabo-Attwood, Tara, Ramos-Nino, Maria E, Eugenia-Ariza, Maria, MacPherson, Maximilian B, Butnor, Kelly J, Vacek, Pamela C, McGee, Sean P, Clark, Jessica C, Steele, Chad, Mossman, Brooke T

“…Inflammation and lung remodeling are hallmarks of asbestos-induced fibrosis, but the molecular mechanisms that control these events are unclear. Using laser…”
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Crocidolite Asbestos and SV40 Are Cocarcinogens in Human Mesothelial Cells and in Causing Mesothelioma in Hamsters by Kroczynska, Barbara, Cutrone, Rochelle, Bocchetta, Maurizio, Yang, Haining, Elmishad, Amira G., Vacek, Pamela, Ramos-Nino, Maria, Mossman, Brooke T., Pass, Harvey I., Carbone, Michele

“…Only a fraction of subjects exposed to asbestos develop malignant mesothelioma (MM), suggesting that additional factors may render some individuals more…”
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Mechanisms of action of inhaled fibers, particles and nanoparticles in lung and cardiovascular diseases by Mossman, Brooke T, Borm, Paul J, Castranova, Vincent, Costa, Daniel L, Donaldson, Kenneth, Kleeberger, Steven R

“…A symposium on the mechanisms of action of inhaled airborne particulate matter (PM), pathogenic particles and fibers such as silica and asbestos, and…”
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Multiple roles of oxidants in the pathogenesis of asbestos-induced diseases by Shukla, Arti, Gulumian, Mary, Hei, Tom K., Kamp, David, Rahman, Qamar, Mossman, Brooke T.

“…Exposure to asbestos causes cellular damage, leading to asbestosis, bronchogenic carcinoma, and mesothelioma in humans. The pathogenesis of asbestos-related…”
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Differences in gene expression and cytokine production by crystalline vs. amorphous silica in human lung epithelial cells by Perkins, Timothy N, Shukla, Arti, Peeters, Paul M, Steinbacher, Jeremy L, Landry, Christopher C, Lathrop, Sherrill A, Steele, Chad, Reynaert, Niki L, Wouters, Emiel F M, Mossman, Brooke T

“…Exposure to respirable crystalline silica particles, as opposed to amorphous silica, is associated with lung inflammation, pulmonary fibrosis (silicosis), and…”
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Mechanistic in vitro studies: What they have told us about carcinogenic properties of elongated mineral particles (EMPs) by Mossman, Brooke T.

“…In vitro studies using target and effecter cells of mineral-induced cancers have been critical in determining the mechanisms of pathogenesis as well as the…”
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ERK2 is essential for the growth of human epithelioid malignant mesotheliomas by Shukla, Arti, Hillegass, Jedd M., MacPherson, Maximilian B., Beuschel, Stacie L., Vacek, Pamela M., Butnor, Kelly J., Pass, Harvey I., Carbone, Michele, Testa, Joseph R., Heintz, Nicholas H., Mossman, Brooke T.

“…Members of the extracellular signal‐regulated kinase (ERK) family may have distinct roles in the development of cell injury and repair, differentiation and…”
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Role and regulation of activator protein-1 in toxicant-induced responses of the lung by Reddy, Sekhar P M, Mossman, Brooke T

“…Aberrant cell proliferation and differentiation after toxic injury to airway epithelium can lead to the development of various lung diseases including cancer…”
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