Silica-Gentamicin Nanohybrids: Synthesis and Antimicrobial Action

Silica-Gentamicin Nanohybrids: Synthesis and Antimicrobial Action

Orthopedic applications commonly require the administration of systemic antibiotics. Gentamicin is one of the most commonly used aminoglycosides in the treatment and prophylaxis of infections associated with orthopedic applications, but gentamicin has a short half-life. However, silica nanoparticles...

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Bibliographic Details
Published in:Materials Vol. 9; no. 3; p. 170
Main Authors: Mosselhy, Dina Ahmed, Ge, Yanling, Gasik, Michael, Nordström, Katrina, Natri, Olli, Hannula, Simo-Pekka
Format: Journal Article
Language:English
Published: Switzerland MDPI AG 05-03-2016
MDPI
Subjects:
Antibiotics
Antiinfectives and antibacterials
antimicrobial effect
Bacillus subtilis
Bacteria
Bones
Composite materials
E coli
Escherichia coli
gentamicin
Gram-negative bacteria
Gram-positive bacteria
Half life
in vitro release
Nanoparticles
Nanostructure
orthopedic applications
Orthopedics
Pseudomonas fluorescens
silica nanoparticles
Silicon dioxide
Finland
gentamicin
antimicrobial effect
orthopedic applications
in vitro release
silica nanoparticles
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Summary:Orthopedic applications commonly require the administration of systemic antibiotics. Gentamicin is one of the most commonly used aminoglycosides in the treatment and prophylaxis of infections associated with orthopedic applications, but gentamicin has a short half-life. However, silica nanoparticles (SiO₂ NPs) can be used as elegant carriers for antibiotics to prolong their release. Our goal is the preparation and characterization of SiO₂-gentamicin nanohybrids for their potential antimicrobial administration in orthopedic applications. gentamicin release profile from the nanohybrids (gentamicin-conjugated SiO₂ NPs) prepared by the base-catalyzed precipitation exhibited fast release (21.4%) during the first 24 h and further extension with 43.9% release during the five-day experiment. Antimicrobial studies of the SiO₂-gentamicin nanohybrids native SiO₂ NPs and free gentamicin were performed against ( ), ( ) and ( ). SiO₂-gentamicin nanohybrids were most effective against . SiO₂ NPs play no antimicrobial role. Parallel antimicrobial studies for the filter-sterilized gentamicin were performed to assess the effect of ultraviolet (UV)-irradiation on gentamicin. In summary, the initial fast gentamicin release fits the need for high concentration of antibiotics after orthopedic surgical interventions. Moreover, the extended release justifies the promising antimicrobial administration of the nanohybrids in bone applications.
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ISSN:1996-1944
1996-1944
DOI:10.3390/ma9030170