Search Results - "Moss, Steven J."

Cell-permeable succinate prodrugs bypass mitochondrial complex I deficiency by Ehinger, Johannes K., Piel, Sarah, Ford, Rhonan, Karlsson, Michael, Sjövall, Fredrik, Frostner, Eleonor Åsander, Morota, Saori, Taylor, Robert W., Turnbull, Doug M., Cornell, Clive, Moss, Steven J., Metzsch, Carsten, Hansson, Magnus J., Fliri, Hans, Elmér, Eskil

“…Mitochondrial complex I (CI) deficiency is the most prevalent defect in the respiratory chain in paediatric mitochondrial disease. This heterogeneous group of…”
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Diversity oriented biosynthesis via accelerated evolution of modular gene clusters by Wlodek, Aleksandra, Kendrew, Steve G., Coates, Nigel J., Hold, Adam, Pogwizd, Joanna, Rudder, Steven, Sheehan, Lesley S., Higginbotham, Sarah J., Stanley-Smith, Anna E., Warneck, Tony, Nur-E-Alam, Mohammad, Radzom, Markus, Martin, Christine J., Overvoorde, Lois, Samborskyy, Markiyan, Alt, Silke, Heine, Daniel, Carter, Guy T., Graziani, Edmund I., Koehn, Frank E., McDonald, Leonard, Alanine, Alexander, Rodríguez Sarmiento, Rosa María, Chao, Suzan Keen, Ratni, Hasane, Steward, Lucinda, Norville, Isobel H., Sarkar-Tyson, Mitali, Moss, Steven J., Leadlay, Peter F., Wilkinson, Barrie, Gregory, Matthew A.

“…Erythromycin, avermectin and rapamycin are clinically useful polyketide natural products produced on modular polyketide synthase multienzymes by an…”
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Mutations in NONO lead to syndromic intellectual disability and inhibitory synaptic defects by Mircsof, Dennis, Langouët, Maéva, Rio, Marlène, Moutton, Sébastien, Siquier-Pernet, Karine, Bole-Feysot, Christine, Cagnard, Nicolas, Nitschke, Patrick, Gaspar, Ludmila, Žnidarič, Matej, Alibeu, Olivier, Fritz, Ann-Kristina, Wolfer, David P, Schröter, Aileen, Bosshard, Giovanna, Rudin, Markus, Koester, Christina, Crestani, Florence, Seebeck, Petra, Boddaert, Nathalie, Prescott, Katrina, Hines, Rochelle, Moss, Steven J, Fritschy, Jean-Marc, Munnich, Arnold, Amiel, Jeanne, Brown, Steven A, Tyagarajan, Shiva K, Colleaux, Laurence

“…Via exome sequencing, the authors identified mutations in the NONO protein, a member of the DBHS family, as a likely cause of severe intellectual disability…”
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Biosynthesis of the immunosuppressants FK506, FK520, and rapamycin involves a previously undescribed family of enzymes acting on chorismate by Andexer, Jennifer N, Kendrew, Steven G, Nur-e-Alam, Mohammad, Lazos, Orestis, Foster, Teresa A, Zimmermann, Anna-Sophie, Warneck, Tony D, Suthar, Dipen, Coates, Nigel J, Koehn, Frank E, Skotnicki, Jerauld S, Carter, Guy T, Gregory, Matthew A, Martin, Christine J, Moss, Steven J, Leadlay, Peter F, Wilkinson, Barrie

“…The macrocyclic polyketides FK506, FK520, and rapamycin are potent immunosuppressants that prevent T-cell proliferation through initial binding to the…”
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Preclinical Characterization of Naturally Occurring Polyketide Cyclophilin Inhibitors from the Sanglifehrin Family by GREGORY, Matthew A, BOBARDT, Michael, NUR-E-ALAM, Mohammad, PAESHUYSE, Jan, PIRAEE, Mahmood, SUTHAR, Dipen, WARNECK, Tony, ZHANG, Ming-Qiang, WILKINSON, Barrie, OBEID, Susan, CHATTERJI, Udayan, COATES, Nigel J, FOSTER, Teresa, GALLAY, Philippe, LEYSSEN, Pieter, MOSS, Steven J, NEYTS, Johan

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Loss of co-linearity by modular polyketide synthases: a mechanism for the evolution of chemical diversity by Moss, Steven J, Martin, Christine J, Wilkinson, Barrie

“…Modular polyketide synthases biosynthesise natural products through successive Claisen-type condensations, where one module is responsible for one round of…”
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Total Synthesis of Chloptosin: A Dimeric Cyclohexapeptide by Oelke, Alexander J., Antonietti, Francesca, Bertone, Leonardo, Cranwell, Philippa B., France, David J., Goss, Rebecca J. M., Hofmann, Tatjana, Knauer, Stephan, Moss, Steven J., Skelton, Paul C., Turner, Richard M., Wuitschik, Georg, Ley, Steven V.

“…Here we describe in full our investigations into the synthesis of the dimeric cyclohexapeptide chloptosin in 17 linear steps. Particularly, this work features…”
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Separation of anti-angiogenic and cytotoxic activities of borrelidin by modification at the C17 side chain by Wilkinson, Barrie, Gregory, Matthew A., Moss, Steven J., Carletti, Isabelle, Sheridan, Rose M., Kaja, Andrew, Ward, Michael, Olano, Carlos, Mendez, Carmen, Salas, José A., Leadlay, Peter F., vanGinckel, Rob, Zhang, Ming-Qiang

“…An SAR analysis of borrelidin analogues is presented. A set of novel borrelidin analogues have been prepared by precursor-directed biosynthesis…”
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Identification of a Set of Genes Involved in the Formation of the Substrate for the Incorporation of the Unusual “Glycolate” Chain Extension Unit in Ansamitocin Biosynthesis by Carroll, Brian J, Moss, Steven J, Bai, Linquan, Kato, Yasuo, Toelzer, Sabine, Yu, Tin-Wein, Floss, Heinz G

“…The unusual “glycolate” extender unit at C-9/C-10 of ansamitocin is not derived from 2-hydroxymalonyl-CoA or 2-methoxymalonyl-CoA, as demonstrated by feeding…”
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Uncovering the origin of Z-configured double bonds in polyketides: intermediate E-double bond formation during borrelidin biosynthesis by Kandziora, Nadine, Andexer, Jennifer N, Moss, Steven J, Wilkinson, Barrie, Leadlay, Peter F, Hahn, Frank

“…Formation of Z -configured double bonds in reduced polyketides is uncommon and their origins have not been extensively studied. To investigate the origin of…”
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The Biosynthetic Gene Cluster of the Maytansinoid Antitumor Agent Ansamitocin from Actinosynnema pretiosum by Yu, Tin-Wein, Bai, Linquan, Clade, Dorothee, Hoffmann, Dietmar, Toelzer, Sabine, Trinh, Khue Q., Xu, Jun, Moss, Steven J., Leistner, Eckhard, Floss, Heinz G.

“…Maytansinoids are potent antitumor agents found in plants and microorganisms. To elucidate their biosynthesis at the biochemical and genetic level and to set…”
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Optimizing Natural Products by Biosynthetic Engineering: Discovery of Nonquinone Hsp90 Inhibitors by Zhang, Ming-Qiang, Gaisser, Sabine, Nur-E-Alam, Mohammad, Sheehan, Lesley S, Vousden, William A, Gaitatzis, Nikolaos, Peck, Gerrard, Coates, Nigel J, Moss, Steven J, Radzom, Markus, Foster, Teresa A, Sheridan, Rose M, Gregory, Matthew A, Roe, S. Mark, Prodromou, Chrisostomos, Pearl, Laurence, Boyd, Susan M, Wilkinson, Barrie, Martin, Christine J

“…A biosynthetic medicinal chemistry approach was applied to the optimization of the natural product Hsp90 inhibitor macbecin. By genetic engineering, mutants…”
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Mutasynthesis of Rapamycin Analogues through the Manipulation of a Gene Governing Starter Unit Biosynthesis by Gregory, Matthew A., Petkovic, Hrvoje, Lill, Rachel E., Moss, Steven J., Wilkinson, Barrie, Gaisser, Sabine, Leadlay, Peter F., Sheridan, Rose M.

“…The surprising discovery has been made that the gene product RapK is required for production of the starter unit in the rapamycin polyketide cluster. It is…”
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On the Biosynthetic Origin of Methoxymalonyl-Acyl Carrier Protein, the Substrate for Incorporation of “Glycolate” Units into Ansamitocin and Soraphen A by Wenzel, Silke C., Williamson, Rachel M., Grünanger, Christian, Xu, Jun, Gerth, Klaus, Martinez, Rodolfo A., Moss, Steven J., Carroll, Brian J., Grond, Stephanie, Unkefer, Clifford J., Müller, Rolf, Floss, Heinz G.

“…Feeding experiments with isotope-labeled precursors rule out hydroxypyruvate and TCA cycle intermediates as the metabolic source of methoxymalonyl-ACP, the…”
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Expeditious Route to Fluorinated Rapamycin Analogues by Utilising Mutasynthesis by Goss, Rebecca J.M, Lanceron, Simon, Deb Roy, Abhijeet, Sprague, Simon, Nur-e-Alam, Mohammed, Hughes, David L, Wilkinson, Barrie, Moss, Steven J

“…Rapamycin is a drug with several important clinical uses. Its complex structure means that total synthesis of this natural product and its analogues is…”
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Recombinant strains for the enhanced production of bioengineered rapalogs by Kendrew, Steven G., Petkovic, Hrvoje, Gaisser, Sabine, Ready, Sarah J., Gregory, Matthew A., Coates, Nigel J., Nur-e-Alam, Mohammad, Warneck, Tony, Suthar, Dipen, Foster, Teresa A., McDonald, Leonard, Schlingman, Gerhard, Koehn, Frank E., Skotnicki, Jerauld S., Carter, Guy T., Moss, Steven J., Zhang, Ming-Qiang, Martin, Christine J., Sheridan, Rose M., Wilkinson, Barrie

“…The rapK gene required for biosynthesis of the DHCHC starter acid that initiates rapamycin biosynthesis was deleted from strain BIOT-3410, a derivative of…”
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Biosynthesis of the angiogenesis inhibitor borrelidin: directed biosynthesis of novel analogues by Moss, Steven J, Carletti, Isabelle, Olano, Carlos, Sheridan, Rose M, Ward, Michael, Math, Vidya, Nur-E-Alam, Mohammad, Braña, Alfredo F, Zhang, Ming Qiang, Leadlay, Peter F, Méndez, Carmen, Salas, José A, Wilkinson, Barrie

“…We report the directed biosynthesis of borrelidin analogues and their selective anti-proliferative activity against human cancer cell lines…”
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Biosynthesis of the angiogenesis inhibitor borrelidin by Streptomyces parvulus Tü4055: insights into nitrile formation by Olano, Carlos, Moss, Steven J., Braña, Alfredo F., Sheridan, Rose M., Math, Vidya, Weston, Alison J., Méndez, Carmen, Leadlay, Peter F., Wilkinson, Barrie, Salas, José A.

“…Summary The 18‐membered polyketide macrolide borrelidin exhibits a number of important biological activities, including potent angiogenesis inhibition. This…”
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Generating rapamycin analogues by directed biosynthesis: starter acid substrate specificity of mono-substituted cyclohexane carboxylic acids by Goss, Rebecca J M, Lanceron, Simon E, Wise, Nicola J, Moss, Steven J

“…We report a convenient synthesis of 4-fluorocyclohexanoic acid, and an insight into the rules governing acceptance of starter acid analogues in the…”
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Isolation of an aldehyde dehydrogenase involved in the oxidation of fluoroacetaldehyde to fluoroacetate in Streptomyces cattleya by MURPHY, Cormac D, MOSS, Steven J, O'HAGAN, David

“…Streptomyces cattleya is unusual in that it produces fluoroacetate and 4-fluorothreonine as secondary metabolites. We now report the isolation of an…”
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