Search Results - "Moss, Stephen J."

Potentiating KCC2 activity is sufficient to limit the onset and severity of seizures by Moore, Yvonne E., Deeb, Tarek Z., Chadchankar, Heramb, Brandon, Nicholas J., Moss, Stephen J.

“…The type 2 K⁺/Cl⁻ cotransporter (KCC2) allows neurons to maintain low intracellular levels of Cl⁻, a prerequisite for efficient synaptic inhibition. Reductions…”
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GABAA receptor trafficking and its role in the dynamic modulation of neuronal inhibition by Jacob, Tija C., Moss, Stephen J., Jurd, Rachel

“…Key Points GABA (γ-aminobutyric acid) type A receptors (GABA A Rs) are GABA-gated, Cl − -selective channels that are responsible for most fast synaptic…”
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Seizing Control of KCC2: A New Therapeutic Target for Epilepsy by Moore, Yvonne E., Kelley, Matt R., Brandon, Nicholas J., Deeb, Tarek Z., Moss, Stephen J.

“…Deficits in GABAergic inhibition result in the abnormal neuronal activation and synchronization that underlies seizures. However, the molecular mechanisms…”
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Inability to suppress the stress-induced activation of the HPA axis during the peripartum period engenders deficits in postpartum behaviors in mice by Melón, Laverne Camille, Hooper, Andrew, Yang, Xuzhong, Moss, Stephen J., Maguire, Jamie

“…•Peripartum suppression of the stress-induced activation of the HPA axis involves maintenance of KCC2 expression in the PVN.•The inability to suppress the HPA…”
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Modulation of neuronal activity by phosphorylation of the K–Cl cotransporter KCC2 by Kahle, Kristopher T, Deeb, Tarek Z, Puskarjov, Martin, Silayeva, Liliya, Liang, Bo, Kaila, Kai, Moss, Stephen J

“…Highlights • The rapid and reversible phosphorylation and/or dephosphorylation of critical phosphoresidues in the KCC2 cytoplasmic carboxyl terminus…”
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G Protein-Gated Potassium Channels: A Link to Drug Addiction by Rifkin, Robert A, Moss, Stephen J, Slesinger, Paul A

“…G protein-gated inwardly rectifying potassium (GIRK) channels are regulators of neuronal excitability in the brain. Knockout mice lacking GIRK channels display…”
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NMDA receptor activity downregulates KCC2 resulting in depolarizing GABAA receptor–mediated currents by Lee, Henry H C, Deeb, Tarek Z, Walker, Joshua A, Davies, Paul A, Moss, Stephen J

“…The authors show that NMDA receptor activation induces a rapid protein phosphatase 1–dependent dephosphorylation and downregulation of the neuron-specific…”
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Antibodies to the GABAB receptor in limbic encephalitis with seizures: case series and characterisation of the antigen by Lancaster, Eric, MD, Lai, Meizan, MD, Peng, Xiaoyu, BS, Hughes, Ethan, PhD, Constantinescu, Radu, MD, Raizer, Jeffrey, MD, Friedman, Daniel, MD, Skeen, Mark B, MD, Grisold, Wolfgang, MD, Kimura, Akio, MD, Ohta, Kouichi, MD, Iizuka, Takahiro, MD, Guzman, Miguel, MD, Graus, Francesc, MD, Moss, Stephen J, PhD, Balice-Gordon, Rita, PhD, Dalmau, Josep, MD

“…Summary Background Some encephalitides or seizure disorders once thought idiopathic now seem to be immune mediated. We aimed to describe the clinical features…”
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Methamphetamine-Evoked Depression of GABAB Receptor Signaling in GABA Neurons of the VTA by Padgett, Claire L., Lalive, Arnaud L., Tan, Kelly R., Terunuma, Miho, Munoz, Michaelanne B., Pangalos, Menelas N., Martínez-Hernández, José, Watanabe, Masahiko, Moss, Stephen J., Luján, Rafael, Lüscher, Christian, Slesinger, Paul A.

“…Psychostimulants induce neuroadaptations in excitatory and fast inhibitory transmission in the ventral tegmental area (VTA). Mechanisms underlying drug-evoked…”
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KCC2 activity is critical in limiting the onset and severity of status epilepticus by Silayeva, Liliya, Deeb, Tarek Z., Hines, Rochelle M., Kelley, Matt R., Munoz, Michaelanne B., Lee, Henry H. C., Brandon, Nicholas J., Dunlop, John, Maguire, Jaime, Davies, Paul A., Moss, Stephen J.

“…Significance Status epilepticus (SE) is defined as a state of continuous unremitting seizures that often exhibits underlying deficits in neuronal inhibition…”
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Developmental seizures and mortality result from reducing GABAA receptor α2-subunit interaction with collybistin by Hines, Rochelle M., Maric, Hans Michael, Hines, Dustin J., Modgil, Amit, Panzanelli, Patrizia, Nakamura, Yasuko, Nathanson, Anna J., Cross, Alan, Deeb, Tarek, Brandon, Nicholas J., Davies, Paul, Fritschy, Jean-Marc, Schindelin, Hermann, Moss, Stephen J.

“…Fast inhibitory synaptic transmission is mediated by γ-aminobutyric acid type A receptors (GABA A Rs) that are enriched at functionally diverse synapses via…”
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Memory Deficits Induced by Inflammation Are Regulated by α5-Subunit-Containing GABAA Receptors by Wang, Dian-Shi, Zurek, Agnieszka A., Lecker, Irene, Yu, Jieying, Abramian, Armen M., Avramescu, Sinziana, Davies, Paul A., Moss, Stephen J., Lu, Wei-Yang, Orser, Beverley A.

“…Systemic inflammation causes learning and memory deficits through mechanisms that remain poorly understood. Here, we studied the pathogenesis of memory loss…”
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Phosphorylation of GABAA receptors influences receptor trafficking and neurosteroid actions by Comenencia-Ortiz, Eydith, Moss, Stephen J., Davies, Paul A.

“…Rationale Gamma-aminobutyric acid type A receptors (GABA A Rs) are the principal mediators of inhibitory transmission in the mammalian central nervous system…”
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Neurosteroids promote phosphorylation and membrane insertion of extrasynaptic GABAA receptors by Abramian, Armen M, Comenencia-Ortiz, Eydith, Modgil, Amit, Vien, Thuy N, Nakamura, Yasuko, Moore, Yvonne E, Maguire, Jamie L, Terunuma, Miho, Davies, Paul A, Moss, Stephen J

“…Neurosteroids are synthesized within the brain and act as endogenous anxiolytic, anticonvulsant, hypnotic, and sedative agents, actions that are principally…”
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Endogenous nonneuronal modulators of synaptic transmission control cortical slow oscillations in vivo by Fellin, Tommaso, Halassa, Michael M, Terunuma, Miho, Succol, Francesca, Takano, Hajime, Frank, Marcos, Moss, Stephen J, Haydon, Philip G

“…Gliotransmission, the release of molecules from astrocytes, regulates neuronal excitability and synaptic transmission in situ. Whether this process affects…”
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Astrocytic Purinergic Signaling Coordinates Synaptic Networks by Pascual, Olivier, Casper, Kristen B, Kubera, Cathryn, Zhang, Jing, Revilla-Sanchez, Raquel, Sul, Jai-Yoon, Takano, Hajime, Moss, Stephen J, McCarthy, Ken, Haydon, Philip G

“…To investigate the role of astrocytes in regulating synaptic transmission, we generated inducible transgenic mice that express a dominant-negative SNARE domain…”
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Tyrosine phosphorylation regulates the membrane trafficking of the potassium chloride co-transporter KCC2 by Lee, Henry H.C., Jurd, Rachel, Moss, Stephen J.

“…The activity of the neuronal-specific potassium chloride co-transporter KCC2 allows neurons to maintain low intracellular Cl − concentrations. These low Cl −…”
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Truncation of the TAR DNA-binding protein 43 is not a prerequisite for cytoplasmic relocalization, and is suppressed by caspase inhibition and by introduction of the A90V sequence variant by Wobst, Heike J, Delsing, Louise, Brandon, Nicholas J, Moss, Stephen J

“…The RNA-binding and -processing protein TAR DNA-binding protein 43 (TDP-43) is heavily linked to the underlying causes and pathology of neurodegenerative…”
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Cyclin E Constrains Cdk5 Activity to Regulate Synaptic Plasticity and Memory Formation by Odajima, Junko, Wills, Zachary P., Ndassa, Yasmine M., Terunuma, Miho, Kretschmannova, Karla, Deeb, Tarek Z., Geng, Yan, Gawrzak, Sylwia, Quadros, Isabel M., Newman, Jennifer, Das, Manjusri, Jecrois, Marie E., Yu, Qunyan, Li, Na, Bienvenu, Frederic, Moss, Stephen J., Greenberg, Michael E., Marto, Jarrod A., Sicinski, Piotr

“…Cyclin E is a component of the core cell cycle machinery, and it drives cell proliferation by regulating entry and progression of cells through the DNA…”
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Disrupted Dentate Granule Cell Chloride Regulation Enhances Synaptic Excitability during Development of Temporal Lobe Epilepsy by Pathak, Hemal R, Weissinger, Florian, Terunuma, Miho, Carlson, Gregory C, Hsu, Fu-Chun, Moss, Stephen J, Coulter, Douglas A

“…GABA(A) receptor-mediated inhibition depends on the maintenance of intracellular Cl- concentration ([Cl-]in) at low levels. In neurons in the developing CNS,…”
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