Search Results - "Moss, Eric G."

Heterochronic Genes and the Nature of Developmental Time by Moss, Eric G.

“…Timing is a fundamental issue in development, with a range of implications from birth defects to evolution. In the roundworm Caenorhabditis elegans,…”
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Lin28 promotes the proliferative capacity of neural progenitor cells in brain development by Yang, Mei, Yang, Si-Lu, Herrlinger, Stephanie, Liang, Chen, Dzieciatkowska, Monika, Hansen, Kirk C, Desai, Ridham, Nagy, Andras, Niswander, Lee, Moss, Eric G, Chen, Jian-Fu

“…Neural progenitor cells (NPCs) have distinct proliferation capacities at different stages of brain development. Lin28 is an RNA-binding protein with two…”
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Developmental Transitions in C. elegans Larval Stages by Rougvie, Ann E., Moss, Eric G.

“…Molecular mechanisms control the timing, sequence, and synchrony of developmental events in multicellular organisms. In Caenorhabditis elegans, these…”
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LIN28 alters cell fate succession and acts independently of the let-7 microRNA during neurogliogenesis in vitro by Balzer, Erica, Heine, Christian, Jiang, Qiang, Lee, Vivian M, Moss, Eric G

“…LIN28 is an RNA-binding protein that is expressed in many developing tissues. It can block let-7 ( Mirlet7 ) microRNA processing and help promote pluripotency…”
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Lin-28 binds IGF-2 mRNA and participates in skeletal myogenesis by increasing translation efficiency by Polesskaya, Anna, Cuvellier, Sylvain, Naguibneva, Irina, Duquet, Arnaud, Moss, Eric G, Harel-Bellan, Annick

“…Lin-28 is a highly conserved, RNA-binding, microRNA-regulated protein that is involved in regulation of developmental timing in Caenorhabditis elegans. In…”
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lin-28 controls the succession of cell fate choices via two distinct activities by Vadla, Bhaskar, Kemper, Kevin, Alaimo, Jennifer, Heine, Christian, Moss, Eric G

“…lin-28 is a conserved regulator of cell fate succession in animals. In Caenorhabditis elegans, it is a component of the heterochronic gene pathway that governs…”
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Localization of the Developmental Timing Regulator Lin28 to mRNP Complexes, P-bodies and Stress Granules by Balzer, Erica, Moss, Eric G.

“…Lin28 is a conserved cytoplasmic protein with an unusual pairing of RNA-binding motifs: a cold shock domain and a pair of retroviral-type CCHC zinc fingers. In…”
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Fetal Deficiency of Lin28 Programs Life‐Long Aberrations in Growth and Glucose Metabolism by Shinoda, Gen, Shyh‐Chang, Ng, Soysa, T. Yvanka de, Zhu, Hao, Seligson, Marc T., Shah, Samar P., Abo‐Sido, Nora, Yabuuchi, Akiko, Hagan, John P., Gregory, Richard I., Asara, John M., Cantley, Lewis C., Moss, Eric G., Daley, George Q.

“…LIN28A/B are RNA binding proteins implicated by genetic association studies in human growth and glucose metabolism. Mice with ectopic over‐expression of Lin28a…”
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Conservation of the heterochronic regulator Lin-28, its developmental expression and microRNA complementary sites by Moss, Eric G, Tang, Lingjuan

“…The heterochronic gene lin-28 is a regulator of developmental timing in the nematode Caenorhabditis elegans. It must be expressed in the first larval stage and…”
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Lin28a Regulates Germ Cell Pool Size and Fertility by Shinoda, Gen, De Soysa, T. Yvanka, Seligson, Marc T., Yabuuchi, Akiko, Fujiwara, Yuko, Huang, Pei Yi, Hagan, John P., Gregory, Richard I., Moss, Eric G., Daley, George Q.

“…Overexpression of LIN28A is associated with human germ cell tumors and promotes primordial germ cell (PGC) development from embryonic stem cells in vitro and…”
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Two Genetic Circuits Repress the Caenorhabditis elegans Heterochronic Gene lin-28 after Translation Initiation by Seggerson, Kathy, Tang, Lingjuan, Moss, Eric G.

“…The heterochronic gene lin-28 of the nematode Caenorhabditis elegans controls the relative timing of diverse developmental events during the animal's larval…”
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Orthologs of the Caenorhabditis elegans heterochronic genes have divergent functions in Caenorhabditis briggsae by Ivanova, Maria, Moss, Eric G

“…Abstract The heterochronic genes of Caenorhabditis elegans comprise the best-studied pathway controlling the timing of tissue and organ formation in an animal…”
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The Cold Shock Domain Protein LIN-28 Controls Developmental Timing in C. elegans and Is Regulated by the lin-4 RNA by Moss, Eric G, Lee, Rosalind C, Ambros, Victor

“…Mutations in the heterochronic gene lin-28 of C. elegans cause precocious development where diverse events specific to the second larval stage are skipped…”
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Temporally regulated expression of Lin-28 in diverse tissues of the developing mouse by Yang, Dong-Hua, Moss, Eric G.

“…The gene lin-28 was originally identified through a mutant of the nematode Caenorhabditis elegans displaying defects in developmental timing. It is expressed…”
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A temporal sequence of heterochronic gene activities promotes stage-specific developmental events in Caenorhabditis elegans by Ivanova, Maria, Moss, Eric G

“…Abstract The heterochronic genes of the nematode Caenorhabditis elegans control the succession of postembryonic developmental events. The 4 core heterochronic…”
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The RNA‐binding protein LIN28 controls progenitor and neuronal cell fate during postnatal neurogenesis by Romer-Seibert, Jennifer S., Hartman, Nathaniel W., Moss, Eric G.

“…ABSTRACT The RNA‐binding protein LIN28 is known to regulate cell fate, tissue growth, and pluripotency; however, a unified understanding of its role at the…”
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An engineered, orthogonal auxin analog/ At TIR1(F79G) pairing improves both specificity and efficacy of the auxin degradation system in Caenorhabditis elegans by Hills-Muckey, Kelly, Martinez, Michael A Q, Stec, Natalia, Hebbar, Shilpa, Saldanha, Joanne, Medwig-Kinney, Taylor N, Moore, Frances E Q, Ivanova, Maria, Morao, Ana, Ward, J D, Moss, Eric G, Ercan, Sevinc, Zinovyeva, Anna Y, Matus, David Q, Hammell, Christopher M

“…Abstract The auxin-inducible degradation system in C. elegans allows for spatial and temporal control of protein degradation via heterologous expression of a…”
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Stage-Specific Timing of the microRNA Regulation of lin-28 by the Heterochronic Gene lin-14 in Caenorhabditis elegans by Tsialikas, Jennifer, Romens, Mitchell A, Abbott, Allison, Moss, Eric G

“…In normal development, the order and synchrony of diverse developmental events must be explicitly controlled. In the nematode Caenorhabditis elegans, the…”
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An engineered, orthogonal auxin analog/AtTIR1(F79G) pairing improves both specificity and efficacy of the auxin degradation system in Caenorhabditis elegans by Hills-Muckey, Kelly, Martinez, Michael A Q, Stec, Natalia, Hebbar, Shilpa, Saldanha, Joanne, Medwig-Kinney, Taylor N, Moore, Frances E Q, Ivanova, Maria, Morao, Ana, Ward, J D, Moss, Eric G, Ercan, Sevinc, Zinovyeva, Anna Y, Matus, David Q, Hammell, Christopher M

“…Abstract The auxin-inducible degradation system in C. elegans allows for spatial and temporal control of protein degradation via heterologous expression of a…”
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The C. elegans heterochronic gene lin-46 affects developmental timing at two larval stages and encodes a relative of the scaffolding protein gephyrin by Pepper, Anita S-R, McCane, Jill E, Kemper, Kevin, Yeung, Denise Au, Lee, Rosalind C, Ambros, Victor, Moss, Eric G

“…The succession of developmental events in the C. elegans larva is governed by the heterochronic genes. When mutated, these genes cause either precocious or…”
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