Search Results - "Mosher, Kira I"

Microglial Beclin 1 Regulates Retromer Trafficking and Phagocytosis and Is Impaired in Alzheimer’s Disease by Lucin, Kurt M., O’Brien, Caitlin E., Bieri, Gregor, Czirr, Eva, Mosher, Kira I., Abbey, Rachelle J., Mastroeni, Diego F., Rogers, Joseph, Spencer, Brian, Masliah, Eliezer, Wyss-Coray, Tony

“…Phagocytosis controls CNS homeostasis by facilitating the removal of unwanted cellular debris. Accordingly, impairments in different receptors or proteins…”
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Preclinical Assessment of Young Blood Plasma for Alzheimer Disease by Middeldorp, Jinte, Lehallier, Benoit, Villeda, Saul A, Miedema, Suzanne S M, Evans, Emily, Czirr, Eva, Zhang, Hui, Luo, Jian, Stan, Trisha, Mosher, Kira I, Masliah, Eliezer, Wyss-Coray, Tony

“…Alzheimer disease (AD) pathology starts long before clinical symptoms manifest, and there is no therapy to treat, delay, or prevent the disease. A shared blood…”
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Human umbilical cord plasma proteins revitalize hippocampal function in aged mice by Castellano, Joseph M., Mosher, Kira I., Abbey, Rachelle J., McBride, Alisha A., James, Michelle L., Berdnik, Daniela, Shen, Jadon C., Zou, Bende, Xie, Xinmin S., Tingle, Martha, Hinkson, Izumi V., Angst, Martin S., Wyss-Coray, Tony

“…Treatment with plasma of an early developmental stage, human umbilical cord, revitalizes the hippocampus and improves cognitive function in aged mice. Human…”
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Young blood reverses age-related impairments in cognitive function and synaptic plasticity in mice by Villeda, Saul A, Plambeck, Kristopher E, Middeldorp, Jinte, Castellano, Joseph M, Mosher, Kira I, Luo, Jian, Smith, Lucas K, Bieri, Gregor, Lin, Karin, Berdnik, Daniela, Wabl, Rafael, Udeochu, Joe, Wheatley, Elizabeth G, Zou, Bende, Simmons, Danielle A, Xie, Xinmin S, Longo, Frank M, Wyss-Coray, Tony

“…Aging is associated with cognitive impairment and degenerative processes in the brain. Here, Tony Wyss-Coray and colleagues report that exposure of aged mice…”
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Neural progenitor cells regulate microglia functions and activity by Mosher, Kira I, Andres, Robert H, Fukuhara, Takeshi, Bieri, Gregor, Hasegawa-Moriyama, Maiko, He, Yingbo, Guzman, Raphael, Wyss-Coray, Tony

“…Neural progenitor cells (NPCs) are known to be influenced by their local environment. However, in the current study, the authors show that NPCs can also…”
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The ageing systemic milieu negatively regulates neurogenesis and cognitive function by Villeda, Saul A., Luo, Jian, Mosher, Kira I., Zou, Bende, Britschgi, Markus, Bieri, Gregor, Stan, Trisha M., Fainberg, Nina, Ding, Zhaoqing, Eggel, Alexander, Lucin, Kurt M., Czirr, Eva, Park, Jeong-Soo, Couillard-Després, Sebastien, Aigner, Ludwig, Li, Ge, Peskind, Elaine R., Kaye, Jeffrey A., Quinn, Joseph F., Galasko, Douglas R., Xie, Xinmin S., Rando, Thomas A., Wyss-Coray, Tony

“…Blood-borne factors affect the ageing brain Regenerative capacity and cognitive function decline during ageing. A study using heterochronic parabiosis, in…”
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Microglial complement receptor 3 regulates brain Aβ levels through secreted proteolytic activity by Czirr, Eva, Castello, Nicholas A, Mosher, Kira I, Castellano, Joseph M, Hinkson, Izumi V, Lucin, Kurt M, Baeza-Raja, Bernat, Ryu, Jae Kyu, Li, Lulin, Farina, Sasha N, Belichenko, Nadia P, Longo, Frank M, Akassoglou, Katerina, Britschgi, Markus, Cirrito, John R, Wyss-Coray, Tony

“…Recent genetic evidence supports a link between microglia and the complement system in Alzheimer's disease (AD). In this study, we uncovered a novel role for…”
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Eosinophils regulate adipose tissue inflammation and sustain physical and immunological fitness in old age by Brigger, Daniel, Riether, Carsten, van Brummelen, Robin, Mosher, Kira I., Shiu, Alicia, Ding, Zhaoqing, Zbären, Noemi, Gasser, Pascal, Guntern, Pascal, Yousef, Hanadie, Castellano, Joseph M., Storni, Federico, Graff-Radford, Neill, Britschgi, Markus, Grandgirard, Denis, Hinterbrandner, Magdalena, Siegrist, Mark, Moullan, Norman, Hofstetter, Willy, Leib, Stephen L., Villiger, Peter M., Auwerx, Johan, Villeda, Saul A., Wyss-Coray, Tony, Noti, Mario, Eggel, Alexander

“…Adipose tissue eosinophils (ATEs) are important in the control of obesity-associated inflammation and metabolic disease. However, the way in which ageing…”
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In vivo assessment of behavioral recovery and circulatory exchange in the peritoneal parabiosis model by Castellano, Joseph M., Palner, Mikael, Li, Shi-Bin, Freeman, G. Mark, Nguyen, Andy, Shen, Bin, Stan, Trisha, Mosher, Kira I., Chin, Frederick T., de Lecea, Luis, Luo, Jian, Wyss-Coray, Tony

“…The sharing of circulation between two animals using a surgical procedure known as parabiosis has created a wealth of information towards our understanding of…”
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Recapitulating complex biological signaling environments using a multiplexed, DNA-patterning approach by Scheideler, Olivia J, Yang, Chun, Kozminsky, Molly, Mosher, Kira I, Falcón-Banchs, Roberto, Ciminelli, Emma C, Bremer, Andrew W, Chern, Sabrina A, Schaffer, David V, Sohn, Lydia L

“…Elucidating how the spatial organization of extrinsic signals modulates cell behavior and drives biological processes remains largely unexplored because of…”
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Neural Progenitor Cells Regulate Microglia Functions and Activity States by Mosher, Kira I., Andres, Robert H., Fukuhara, Takeshi, Bieri, Gregor, Hasegawa-Moriyama, Maiko, He, Yingbo, Guzman, Raphael, Wyss-Coray, Tony

“…We observed that mouse neural progenitor cells (NPCs) have a secretory protein profile distinct from other brain cells and modulate microglial activation,…”
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