Search Results - "Moses, John E."

The growing applications of click chemistry by Moses, John E, Moorhouse, Adam D

“…Click chemistry, the subject of this tutorial review, is a modular synthetic approach towards the assembly of new molecular entities. This powerful strategy…”
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Copper‐Catalyzed Azide–Alkyne Cycloaddition: Regioselective Synthesis of 1,4,5‐Trisubstituted 1,2,3‐Triazoles by Spiteri, Christian, Moses, John E.

“…Clicking along nicely: Few methods have been reported to be an efficient entry to trisubstituted triazoles with high regioselectivity. This challenge has…”
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SuFEx-enabled, agnostic discovery of covalent inhibitors of human neutrophil elastase by Zheng, Qinheng, Woehl, Jordan L., Kitamura, Seiya, Santos-Martins, Diogo, Smedley, Christopher J., Li, Gencheng, Forli, Stefano, Moses, John E., Wolan, Dennis W., Sharpless, K. Barry

“…Sulfur fluoride exchange (SuFEx) has emerged as the new generation of click chemistry. We report here a SuFEx-enabled, agnostic approach for the discovery and…”
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Biocompatible SuFEx Click Chemistry: Thionyl Tetrafluoride (SOF4)‐Derived Connective Hubs for Bioconjugation to DNA and Proteins by Liu, Feng, Wang, Hua, Li, Suhua, Bare, Grant A. L., Chen, Xuemin, Wang, Chu, Moses, John E., Wu, Peng, Sharpless, K. Barry

“…We report here the development of a suite of biocompatible SuFEx transformations from the SOF4‐derived iminosulfur oxydifluoride hub in aqueous buffer…”
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Diversity Oriented Clicking (DOC): Divergent Synthesis of SuFExable Pharmacophores from 2‐Substituted‐Alkynyl‐1‐Sulfonyl Fluoride (SASF) Hubs by Smedley, Christopher J., Li, Gencheng, Barrow, Andrew S., Gialelis, Timothy L., Giel, Marie‐Claire, Ottonello, Alessandra, Cheng, Yunfei, Kitamura, Seiya, Wolan, Dennis W., Sharpless, K. Barry, Moses, John E.

“…Diversity Oriented Clicking (DOC) is a unified click‐approach for the modular synthesis of lead‐like structures through application of the wide family of click…”
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Chemoselective Synthesis of Polysubstituted Pyridines from Heteroaryl Fluorosulfates by Zhang, Enxuan, Tang, Jiaze, Li, Suhua, Wu, Peng, Moses, John E., Sharpless, K. Barry

“…A selection of heteroaryl fluorosulfates were readily synthesized using commercial SO2F2 gas. These substrates are highly efficient coupling partners in the…”
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New Synthesis of 1-Substituted-1H-indazoles via 1,3-Dipolar Cycloaddition of in situ Generated Nitrile Imines and Benzyne by Spiteri, Christian, Keeling, Steve, Moses, John E

“…A new synthesis of 1-substitued-1H-indazoles via 1,3-dipolar cycloaddition of nitrile imines to benzyne is described. The reaction is completed within 5 min,…”
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Metal‐Free Synthesis of Functional 1‐Substituted‐1,2,3‐Triazoles from Ethenesulfonyl Fluoride and Organic Azides by Giel, Marie‐Claire, Smedley, Christopher J., Mackie, Emily R. R., Guo, Taijie, Dong, Jiajia, Soares da Costa, Tatiana P., Moses, John E.

“…The boom in growth of 1,4‐disubstituted triazole products, in particular, since the early 2000’s, can be largely attributed to the birth of click chemistry and…”
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Carbene footprinting accurately maps binding sites in protein–ligand and protein–protein interactions by Manzi, Lucio, Barrow, Andrew S., Scott, Daniel, Layfield, Robert, Wright, Timothy G., Moses, John E., Oldham, Neil J.

“…Specific interactions between proteins and their binding partners are fundamental to life processes. The ability to detect protein complexes, and map their…”
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Quantitative and Orthogonal Formation and Reactivity of SuFEx Platforms by Gahtory, Digvijay, Sen, Rickdeb, Pujari, Sidharam, Li, Suhua, Zheng, Qinheng, Moses, John E., Sharpless, K. Barry, Zuilhof, Han

“…The constraints of minute reactant amounts and the impossibility to remove any undesired surface‐bound products during monolayer functionalization of a surface…”
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Sulfur–Fluoride Exchange (SuFEx)‐Mediated Synthesis of Sterically Hindered and Electron‐Deficient Secondary and Tertiary Amides via Acyl Fluoride Intermediates by Smedley, Christopher J., Barrow, Andrew S., Spiteri, Christian, Giel, Marie‐Claire, Sharma, Pallavi, Moses, John E.

“…Amide bond formation is one of the most executed reactions in chemistry and biology. This is largely due to the ubiquity of the amide functional group in…”
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Copper-Catalyzed Azide-Alkyne Cycloaddition: Regioselective Synthesis of 1,4,5-Trisubstituted 1,2,3-Triazoles by Spiteri, Christian, Moses, John E.

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Mechanism of intersubunit ketosynthase–dehydratase interaction in polyketide synthases by Jenner, Matthew, Kosol, Simone, Griffiths, Daniel, Prasongpholchai, Panward, Manzi, Lucio, Barrow, Andrew S, Moses, John E, Oldham, Neil J, Lewandowski, Józef R, Challis, Gregory L

“…A combination of biochemical and structural techniques allows the characterization of a novel docking domain in polyketide synthases, which is structurally…”
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Tuneable DNA-based asymmetric catalysis using a G-quadruplex supramolecular assembly by Roe, Stephen, Ritson, Dougal J, Garner, Tom, Searle, Mark, Moses, John E

“…Described is the first modular construction of a G-quadruplex chiral catalyst. The key objective was to use G-quadruplex structures to act as chiral ligands…”
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Stabilization of G-Quadruplex DNA by Highly Selective Ligands via Click Chemistry by Moorhouse, Adam D, Santos, Ana Mafalda, Gunaratnam, Mekala, Moore, Michael, Neidle, Stephen, Moses, John E

“…A series of G-quadruplex stabilizing compounds have been prepared via click chemistry employing the Cu(I)-catalyzed Huisgen reaction. These compounds were…”
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Structural characterization of the apo form and NADH binary complex of human lactate dehydrogenase by Dempster, Sally, Harper, Stephen, Moses, John E., Dreveny, Ingrid

“…Lactate dehydrogenase A (LDH‐A) is a key enzyme in anaerobic respiration that is predominantly found in skeletal muscle and catalyses the reversible conversion…”
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Protocol for producing phosphoramidate using phosphorus fluoride exchange click chemistry by Homer, Joshua A., Sun, Shoujun, Koelln, Rebecca A., Moses, John E.

“…Phosphorus fluoride exchange (PFEx) is a catalytic click reaction that involves exchanging high oxidation state P–F bonds with alcohol and amine nucleophiles,…”
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A fragment based click chemistry approach towards hybrid G-quadruplex ligands: design, synthesis and biophysical evaluation by Ritson, Dougal J., Moses, John E.

“…A library of hybrid oxazole–triazole based compounds containing contiguously linked aromatic units were synthesised as G-quadruplex binding ligands. The design…”
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Biomimetic Approaches Towards The Synthesis of Complex Dimeric Natural Products by Stanley, Paul A, Spiteri, Christian, Moore, Jonathan C, Barrow, Andrew S, Sharma, Pallavi, Moses, John E

“…We present a selection of elegant and diverse biomimetic syntheses of complex natural product dimers. The dimerisation pathways discussed encompass the most…”
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Formal synthesis of kingianin A based upon a novel electrochemically-induced radical cation Diels-Alder reaction by Moore, Jonathan C, Davies, E Stephen, Walsh, Darren A, Sharma, Pallavi, Moses, John E

“…The application of electrochemical reactions in natural product synthesis has burgeoned in recent years. We herein report a formal synthesis of the complex and…”
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