Search Results - "Moser, K.L."

Recent insights into the genetic basis of systemic lupus erythematosus by Moser, K L, Kelly, J A, Lessard, C J, Harley, J B

“…Genetic variation was first shown to be important in systemic lupus erythematosus (SLE or lupus) in the 1970s with associations in the human leukocyte antigen…”
Get full text

Peripheral blood gene expression profiling in Sjögren's syndrome by Emamian, E S, Leon, J M, Lessard, C J, Grandits, M, Baechler, E C, Gaffney, P M, Segal, B, Rhodus, N L, Moser, K L

“…Sjögren's syndrome (SS) is a common chronic autoimmune disease characterized by lymphocytic infiltration of exocrine glands. The affected cases commonly…”
Get full text

The rs4774 CIITA missense variant is associated with risk of systemic lupus erythematosus by Bronson, P G, Goldstein, B A, Ramsay, P P, Beckman, K B, Noble, J A, Lane, J A, Seldin, M F, Kelly, J A, Harley, J B, Moser, K L, Gaffney, P M, Behrens, T W, Criswell, L A, Barcellos, L F

“…The major histocompatibility complex (MHC) class II transactivator gene ( CIITA ) encodes an important transcription factor required for human leukocyte…”
Get full text

Evaluation of C1q genomic region in minority racial groups of lupus by Namjou, B, Gray-McGuire, C, Sestak, A L, Gilkeson, G S, Jacob, C O, Merrill, J T, James, J A, Wakeland, E K, Li, Q-Z, Langefeld, C D, Divers, J, Ziegler, J, Moser, K L, Kelly, J A, Kaufman, K M, Harley, J B

“…Complement cascade plasma proteins play a complex role in the etiopathogenesis of systemic lupus erythematosus (SLE). Hereditary C1q deficiency has been…”
Get full text

Identification of new SLE-associated genes with a two-step Bayesian study design by Armstrong, D L, Reiff, A, Myones, B L, Quismorio, F P, Klein-Gitelman, M, McCurdy, D, Wagner-Weiner, L, Silverman, E, Ojwang, J O, Kaufman, K M, Kelly, J A, Merrill, J T, Harley, J B, Bae, S-C, Vyse, T J, Gilkeson, G S, Gaffney, P M, Moser, K L, Putterman, C, Edberg, J C, Brown, E E, Ziegler, J, Langefeld, C D, Zidovetzki, R, Jacob, C O

“…In our earlier study, we utilized a Bayesian design to probe the association of ∼1000 genes (∼10 000 single-nucleotide polymorphisms (SNPs)) with systemic…”
Get full text

Replication of the BANK1 genetic association with systemic lupus erythematosus in a European-derived population by Guo, L, Deshmukh, H, Lu, R, Vidal, G S, Kelly, J A, Kaufman, K M, Dominguez, N, Klein, W, Kim-Howard, X, Bruner, G R, Scofield, R H, Moser, K L, Gaffney, P M, Dozmorov, I M, Gilkeson, G S, Wakeland, E K, Li, Q-Z, Langefeld, C D, Marion, M C, Williams, A H, Divers, J, Alarcón, G S, Brown, E E, Kimberly, R P, Edberg, J C, Ramsey-Goldman, R, Reveille, J D, McGwin, G, Vilá, L M, Petri, M A, Vyse, T J, Merrill, J T, James, J A, Nath, S K, Harley, J B, Guthridge, J M

“…Systemic lupus erythematosus (SLE) is an autoimmune disease with highly variable clinical presentation. Patients suffer from immunological abnormalities that…”
Get full text

Complement receptor 2 polymorphisms associated with systemic lupus erythematosus modulate alternative splicing by Douglas, K B, Windels, D C, Zhao, J, Gadeliya, A V, Wu, H, Kaufman, K M, Harley, J B, Merrill, J, Kimberly, R P, Alarcón, G S, Brown, E E, Edberg, J C, Ramsey-Goldman, R, Petri, M, Reveille, J D, Vilá, L M, Gaffney, P M, James, J A, Moser, K L, Alarcón-Riquelme, M E, Vyse, T J, Gilkeson, G S, Jacob, C O, Ziegler, J T, Langefeld, C D, Ulgiati, D, Tsao, B P, Boackle, S A

“…Genetic factors influence susceptibility to systemic lupus erythematosus (SLE). A recent family-based analysis in Caucasian and Chinese populations provided…”
Get full text

Genome Scan of Human Systemic Lupus Erythematosus by Regression Modeling: Evidence of Linkage and Epistasis at 4p16-15.2 by Gray-McGuire, C., Moser, K.L., Gaffney, P.M., Kelly, J., Yu, H., Olson, J.M., Jedrey, C.M., Jacobs, K.B., Kimberly, R.P., Neas, B.R., Rich, S.S., Behrens, T.W., Harley, J.B.

“…Systemic lupus erythematosus (SLE) is a complex autoimmune disorder involving at least hormonal, environmental, and genetic factors. Familial aggregation, a…”
Get full text

Variation in the upstream region of P-Selectin (SELP) is a risk factor for SLE by Morris, D L, Graham, R R, Erwig, L-P, Gaffney, P M, Moser, K L, Behrens, T W, Vyse, T J, Graham, D S Cunninghame

“…Systemic lupus erythematosus (SLE) is a complex autoimmune disease. Genome-wide linkage studies implicated a region containing the adhesion molecule…”
Get full text

Variation in the ATP-binding cassette transporter 2 gene is a separate risk factor for systemic lupus erythematosus within the MHC by Ramos, P S, Langefeld, C D, Bera, L A, Gaffney, P M, Noble, J A, Moser, K L

“…The ATP-binding cassette transporter (TAP) proteins are functionally relevant candidates for predisposition to systemic lupus erythematosus (SLE) by virtue of…”
Get full text