Search Results - "Moseley, Robert"
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AutoGater: a weakly supervised neural network model to gate cells in flow cytometric analyses
Published in Scientific reports (09-10-2024)“…Flow cytometry is a useful and efficient method for the rapid characterization of a cell population based on the optical and fluorescence properties of…”
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Experimental guidance for discovering genetic networks through hypothesis reduction on time series
Published in PLoS computational biology (01-10-2022)“…Large programs of dynamic gene expression, like cell cyles and circadian rhythms, are controlled by a relatively small "core" network of transcription factors…”
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A yeast cell cycle pulse generator model shows consistency with multiple oscillatory and checkpoint mutant datasets
Published in Mathematical biosciences (01-01-2024)“…Modeling biological systems holds great promise for speeding up the rate of discovery in systems biology by predicting experimental outcomes and suggesting…”
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Conservation of dynamic characteristics of transcriptional regulatory elements in periodic biological processes
Published in BMC bioinformatics (17-03-2022)“…Cell and circadian cycles control a large fraction of cell and organismal physiology by regulating large periodic transcriptional programs that encompass…”
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Conservation and Diversification of Circadian Rhythmicity Between a Model Crassulacean Acid Metabolism Plant Kalanchoë fedtschenkoi and a Model C 3 Photosynthesis Plant Arabidopsis thaliana
Published in Frontiers in plant science (28-11-2018)“…Crassulacean acid metabolism (CAM) improves photosynthetic efficiency under limited water availability relative to C photosynthesis. It is widely accepted that…”
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Inherent Dynamics Visualizer, an Interactive Application for Evaluating and Visualizing Outputs from a Gene Regulatory Network Inference Pipeline
Published in Journal of visualized experiments (07-12-2021)“…Developing gene regulatory network models is a major challenge in systems biology. Several computational tools and pipelines have been developed to tackle this…”
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Conservation and Diversification of Circadian Rhythmicity Between a Model Crassulacean Acid Metabolism Plant Kalanchoë fedtschenkoi and a Model C3 Photosynthesis Plant Arabidopsis thaliana
Published in Frontiers in plant science (28-11-2018)“…Crassulacean acid metabolism (CAM) improves photosynthetic efficiency under limited water availability relative to C3 photosynthesis. It is widely accepted…”
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Comparative Genomics Analysis Provides New Insight Into Molecular Basis of Stomatal Movement in Kalanchoë fedtschenkoi
Published in Frontiers in plant science (13-03-2019)“…CO uptake and water loss in plants are regulated by microscopic pores on the surface of leaves, called stomata. This enablement of gas exchange by the opening…”
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The parasite intraerythrocytic cycle and human circadian cycle are coupled during malaria infection
Published in Proceedings of the National Academy of Sciences - PNAS (13-06-2023)“…During infections with the malaria parasites , patients exhibit rhythmic fevers every 48 h. These fever cycles correspond with the time the parasites take to…”
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Perspectives on the basic and applied aspects of crassulacean acid metabolism (CAM) research
Published in Plant science (Limerick) (01-09-2018)“…•CRISPR/Cas-mediated genome editing and high-throughput phenotyping have great potential for CAM functional genomics research.•Challenges and solutions of…”
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Abstract 183: Evaluating targeted therapy combination for refractory colorectal cancer using MicroOrganoSpheres (MOS)
Published in Cancer research (Chicago, Ill.) (04-04-2023)“…Metastatic colorectal cancer (CRC) patients who have become resistant to standard-of-care (SOC) treatments are often put on targeted therapies, including…”
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Inference of Gene Regulatory Network Uncovers the Linkage between Circadian Clock and Crassulacean Acid Metabolism in Kalanchoë fedtschenkoi
Published in Cells (Basel, Switzerland) (27-08-2021)“…The circadian clock drives time-specific gene expression, enabling biological processes to be temporally controlled. Plants that conduct crassulacean acid…”
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Round Trip: An Automated Pipeline for Experimental Design, Execution, and Analysis
Published in ACS synthetic biology (18-02-2022)“…Synthetic biology is a complex discipline that involves creating detailed, purpose-built designs from genetic parts. This process is often phrased as a…”
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The Kalanchoë genome provides insights into convergent evolution and building blocks of crassulacean acid metabolism
Published in Nature communications (01-12-2017)“…Crassulacean acid metabolism (CAM) is a water-use efficient adaptation of photosynthesis that has evolved independently many times in diverse lineages of…”
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Historical Landscape Change in Northwestern Yunnan, China: Using Repeat Photography to Assess the Perceptions and Realities of Biodiversity Loss
Published in Mountain research and development (01-08-2006)“…Biodiversity conservation programs rely on accurate knowledge about past rates of ecological change and patterns of human use. In remote areas of the world,…”
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Impact of Sickle Cell Trait Hemoglobin on the Intraerythrocytic Transcriptional Program of Plasmodium falciparum
Published in mSphere (27-10-2021)“…Sickle-trait hemoglobin (HbAS) confers nearly complete protection from severe, life-threatening falciparum malaria in African children. Despite this clear…”
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Robustness and reproducibility of simple and complex synthetic logic circuit designs using a DBTL loop
Published in Synthetic biology (Oxford University Press) (2023)“…Abstract Computational tools addressing various components of design–build–test–learn (DBTL) loops for the construction of synthetic genetic networks exist but…”
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Conserving the Sacred Medicine Mountains: A Vegetation Analysis of Tibetan Sacred Sites in Northwest Yunnan
Published in Biodiversity and conservation (01-12-2005)“…Mount Kawa Karpo of the Menri ('Medicine Mountains' in Tibetan), in the eastern Himalayas, is one of the most sacred mountains to Tibetan Buddhists. Numerous…”
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Plant diversity and priority conservation areas of Northwestern Yunnan, China
Published in Biodiversity and conservation (01-03-2007)“…The Global Plant Conservation Strategy of the Convention on Biological Diversity calls for “protection of 50% of the most important areas for plant diversity.”…”
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Sudden early‐morning awakening impairs immediate tactical planning in a changing ‘emergency’ scenario
Published in Journal of sleep research (01-06-2011)“…Summary This was a realistic military‐type exercise assessing unexpected, abrupt early‐morning awakening effects on immediate ‘executive function’ and the…”
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