Search Results - "Moseley, Paul M."

Evaluation of CDK12 Protein Expression as a Potential Novel Biomarker for DNA Damage Response-Targeted Therapies in Breast Cancer by Naidoo, Kalnisha, Wai, Patty T, Maguire, Sarah L, Daley, Frances, Haider, Syed, Kriplani, Divya, Campbell, James, Mirza, Hasan, Grigoriadis, Anita, Tutt, Andrew, Moseley, Paul M, Abdel-Fatah, Tarek M A, Chan, Stephen Y T, Madhusudan, Srinivasan, Rhaka, Emad A, Ellis, Ian O, Lord, Christopher J, Yuan, Yinyin, Green, Andrew R, Natrajan, Rachael

“…Disruption of Cyclin-Dependent Kinase 12 ( ) is known to lead to defects in DNA repair and sensitivity to platinum salts and PARP1/2 inhibitors. However, has…”
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Immune-Phenotyping and Transcriptomic Profiling of Peripheral Blood Mononuclear Cells From Patients With Breast Cancer: Identification of a 3 Gene Signature Which Predicts Relapse of Triple Negative Breast Cancer by Foulds, Gemma A, Vadakekolathu, Jayakumar, Abdel-Fatah, Tarek M A, Nagarajan, Divya, Reeder, Stephen, Johnson, Catherine, Hood, Simon, Moseley, Paul M, Chan, Stephen Y T, Pockley, A Graham, Rutella, Sergio, McArdle, Stephanie E B

“…Interactions between the immune system and tumors are highly reciprocal in nature, leading to speculation that tumor recurrence or therapeutic resistance could…”
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Transcriptomic and Protein Expression Analysis Reveals Clinicopathological Significance of Bloom Syndrome Helicase (BLM) in Breast Cancer by Arora, Arvind, Abdel-Fatah, Tarek M A, Agarwal, Devika, Doherty, Rachel, Moseley, Paul M, Aleskandarany, Mohammed A, Green, Andrew R, Ball, Graham, Alshareeda, Alaa T, Rakha, Emad A, Chan, Stephen Y T, Ellis, Ian O, Madhusudan, Srinivasan

“…Bloom syndrome helicase (BLM) has key roles in homologous recombination repair, telomere maintenance, and DNA replication. Germ-line mutations in the BLM gene…”
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SPAG5 as a prognostic biomarker and chemotherapy sensitivity predictor in breast cancer: a retrospective, integrated genomic, transcriptomic, and protein analysis by Abdel-Fatah, Tarek M A, PhD, Agarwal, Devika, MSc, Liu, Dong-Xu, PhD, Russell, Roslin, PhD, Rueda, Oscar M, PhD, Liu, Karen, MSc, Xu, Bing, PhD, Moseley, Paul M, BSc, Green, Andrew R, PhD, Pockley, Alan G, Prof, Rees, Robert C, Prof, Caldas, Carlos, Prof, Ellis, Ian O, Prof, Ball, Graham R, Prof, Chan, Stephen Y T, Prof

“…Summary Background Proliferation markers and profiles have been recommended for guiding the choice of systemic treatments for breast cancer. However, the best…”
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Targeting ataxia telangiectasia-mutated- and Rad3-related kinase (ATR) in PTEN-deficient breast cancers for personalized therapy by Al-Subhi, Nouf, Ali, Reem, Abdel-Fatah, Tarek, Moseley, Paul M., Chan, Stephen Y. T., Green, Andrew R., Ellis, Ian O., Rakha, Emad A., Madhusudan, Srinivasan

“…Purpose Phosphate and tensin homolog (PTEN), a negative regulator of PI3K signaling, is involved in DNA repair. ATR is a key sensor of DNA damage and…”
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Dopamine and cAMP-regulated phosphoprotein 32 kDa (DARPP-32) and survival in breast cancer: a retrospective analysis of protein and mRNA expression by Kotecha, Shreeya, Lebot, Marie N., Sukkarn, Bhudsaban, Ball, Graham, Moseley, Paul M., Chan, Stephen Y., Green, Andrew R., Rakha, Emad, Ellis, Ian O., Martin, Stewart G., Storr, Sarah J.

“…Dopamine and cAMP regulated phosphoprotein 32 kDa (DARPP-32) also known as phosphoprotein phosphatase-1 regulatory subunit 1B and encoded by the PPP1R1B gene…”
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Untangling the ATR-CHEK1 network for prognostication, prediction and therapeutic target validation in breast cancer by Abdel-Fatah, Tarek M.A., Middleton, Fiona K., Arora, Arvind, Agarwal, Devika, Chen, Tao, Moseley, Paul M., Perry, Christina, Doherty, Rachel, Chan, Stephen, Green, Andrew R., Rakha, Emad, Ball, Graham, Ellis, Ian O., Curtin, Nicola J., Madhusudan, Srinivasan

“…ATR-CHEK1 signalling is critical for genomic stability. ATR-CHEK1 signalling may be deregulated in breast cancer and have prognostic, predictive and…”
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Clinicopathological and prognostic significance of RECQL5 helicase expression in breast cancers by Arora, Arvind, Abdel-Fatah, Tarek M A, Agarwal, Devika, Doherty, Rachel, Croteau, Deborah L, Moseley, Paul M, Hameed, Khalid, Green, Andrew, Aleskandarany, Mohammed A, Rakha, Emad A, Patterson, Karl, Ball, Graham, Chan, Stephen Y T, Ellis, Ian O, Bohr, Vilhelm A, Bryant, Helen E, Madhusudan, Srinivasan

“…RECQL5 is a member of the RecQ family of DNA helicases and has key roles in homologous recombination, base excision repair, replication and transcription. The…”
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Clinicopathological Significance of ATM-Chk2 Expression in Sporadic Breast Cancers: a Comprehensive Analysis in Large Cohorts by Abdel-Fatah, Tarek M.A, Arora, Arvind, Alsubhi, Nouf, Agarwal, Devika, Moseley, Paul M, Perry, Christina, Doherty, Rachel, Chan, Stephen Y.T, Green, Andrew R, Rakha, Emad, Ball, Graham, Ellis, Ian O, Madhusudan, Srinivasan

“…Abstract ATM-Chk2 network is critical for genomic stability, and its deregulation may influence breast cancer pathogenesis. We investigated ATM and Chk2…”
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Is there a role for base excision repair in estrogen/estrogen receptor-driven breast cancers? by Abdel-Fatah, Tarek M A, Perry, Christina, Arora, Arvind, Thompson, Nicola, Doherty, Rachel, Moseley, Paul M, Green, Andrew R, Chan, Stephen Y T, Ellis, Ian O, Madhusudan, Srinivasan

“…Estrogen and estrogen metabolite-induced reactive oxygen species generation can promote oxidative DNA base damage. If unrepaired, base damaging lesions could…”
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HAGE in Triple-Negative Breast Cancer Is a Novel Prognostic, Predictive, and Actionable Biomarker: A Transcriptomic and Protein Expression Analysis by Abdel-Fatah, Tarek M A, McArdle, Stephanie E B, Agarwal, Devika, Moseley, Paul M, Green, Andrew R, Ball, Graham R, Pockley, A Graham, Ellis, Ian O, Rees, Robert C, Chan, Stephen Y T

“…The expression of HAGE as a novel prognostic and predictive tool was assessed in 1,079 triple-negative breast cancers (TNBC). HAGE protein expression was…”
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Nottingham Clinico-Pathological Response Index (NPRI) after neoadjuvant chemotherapy (Neo-ACT) accurately predicts clinical outcome in locally advanced breast cancer by Abdel-Fatah, Tarek M, Ball, Graham, Lee, Andrew H S, Pinder, Sarah, MacMilan, R Douglas, Cornford, Eleanor, Moseley, Paul M, Silverman, Rafael, Price, James, Latham, Bruce, Palmer, David, Chan, Arlene, Ellis, Ian O, Chan, Stephen Y T

“…There is a need to identify more sensitive clinicopathologic criteria to assess the response to neoadjuvant chemotherapy (Neo-ACT) and guide subsequent…”
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High mobility group protein B1 is a predictor of poor survival in ovarian cancer by Machado, Lee R, Moseley, Paul M, Moss, Robert, Deen, Suha, Nolan, Christopher, Spendlove, Ian, Ramage, Judith M, Chan, Stephen Yt, Durrant, Lindy G

“…High-mobility group protein B1 (HMGB1) has been implicated in numerous tumour types where expression regulates tumour cell growth and survival. We hypothesised…”
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ERCC1 Is a Predictor of Anthracycline Resistance and Taxane Sensitivity in Early Stage or Locally Advanced Breast Cancers by Abdel-Fatah, Tarek M A, Ali, Reem, Sadiq, Maaz, Moseley, Paul M, Mesquita, Katia A, Ball, Graham, Green, Andrew R, Rakha, Emad A, Chan, Stephen Y T, Madhusudan, Srinivasan

“…Genomic instability could be a beneficial predictor for anthracycline or taxane chemotherapy. We interrogated 188 DNA repair genes in the METABRIC cohort ( =…”
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SHON expression predicts response and relapse risk of breast cancer patients after anthracycline-based combination chemotherapy or tamoxifen treatment by Abdel-Fatah, Tarek M. A., Broom, Reuben J., Lu, Jun, Moseley, Paul M., Huang, Baiqu, Li, Lili, Liu, Suling, Chen, Longxin, Ma, Runlin Z., Cao, Wenming, Wang, Xiaojia, Li, Yan, Perry, Jo K., Aleskandarany, Mohammed, Nolan, Christopher C., Rakha, Emad A., Lobie, Peter E., Chan, Stephen Y. T., Ellis, Ian O., Hwang, Le-Ann, Lane, David P., Green, Andrew R., Liu, Dong-Xu

“…Background SHON nuclear expression (SHON-Nuc + ) was previously reported to predict clinical outcomes to tamoxifen therapy in ERα + breast cancer (BC). Herein…”
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Calpain-1 is associated with adverse relapse free survival in breast cancer: a confirmatory study by Pu, Xuan, Storr, Sarah J, Ahmad, Narmeen S, Chan, Stephen Y, Moseley, Paul M, Televantou, Despina, Cresti, Nicola, Boddy, Alan, Ellis, Ian O, Martin, Stewart G

“…Aims Calpain‐1 is a ubiquitously expressed calcium‐activated intracellular cysteine protease. Altered expression of calpain system proteins has been implicated…”
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DNA repair prognostic index modelling reveals an essential role for base excision repair in influencing clinical outcomes in ER negative and triple negative breast cancers by Abdel-Fatah, Tarek M A, Arora, Arvind, Moseley, Paul M, Perry, Christina, Rakha, Emad A, Green, Andrew R, Chan, Stephen Y T, Ellis, Ian O, Madhusudan, Srinivasan

“…Stratification of oestrogen receptor (ER) negative and triple negative breast cancers (TNBCs) is urgently needed. In the current study, a cohort of 880 ER-…”
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Association of Sperm-Associated Antigen 5 and Treatment Response in Patients With Estrogen Receptor-Positive Breast Cancer by Abdel-Fatah, Tarek M A, Ball, Graham R, Thangavelu, Pulari U, Reid, Lynne E, McCart Reed, Amy E, Saunus, Jodi M, Duijf, Pascal H G, Simpson, Peter T, Lakhani, Sunil R, Pongor, Lorinc, Gyorffy, Balázs, Moseley, Paul M, Green, Andrew R, Pockley, Alan G, Caldas, Carlos, Ellis, Ian O, Chan, Stephen Y T

“…There is no proven test that can guide the optimal treatment, either endocrine therapy or chemotherapy, for estrogen receptor-positive breast cancer. To…”
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Chk1 phosphorylated at serine345 is a predictor of early local recurrence and radio-resistance in breast cancer by Alsubhi, Nouf, Middleton, Fiona, Abdel-Fatah, Tarek M.A., Stephens, Peter, Doherty, Rachel, Arora, Arvind, Moseley, Paul M., Chan, Stephen Y.T., Aleskandarany, Mohammed A., Green, Andrew R., Rakha, Emad A., Ellis, Ian O., Martin, Stewart G., Curtin, Nicola J., Madhusudan, Srinivasan

“…Radiation-induced DNA damage activates the DNA damage response (DDR). DDR up-regulation may predict radio-resistance and increase the risk of early local…”
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Evidence that neoadjuvant anthracycline based combination chemotherapy (NACT) in breast cancer (BC) induces phenotypical changes which guides the optimal adjuvant therapy by Abdel-Fatah, Tarek Mohamed Ahmed, Webb, Rebekah, Li, Ruizhe, Chen, Xin, Giannotti, Elisabetta, Auer, Dorothee, Walker, Jennifer, Moseley, Paul M, Pockley, A. Graham, Ball, Graham, Ellis, Ian O., Rakhah, Emad, Hodi, Zsolt, Lee, Andrew, Chan, Arlene, Chan, Stephen

“…Abstract only 590 Background: We hereby evaluated the histopathological and radiological alterations of tumor characteristics after receiving NACT and the…”
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