Search Results - "Moseley, Jonathan D."

Energy Efficiency of Microwave- and Conventionally Heated Reactors Compared at meso Scale for Organic Reactions by Moseley, Jonathan D, Woodman, Emily K

“…This study reports on the energy efficiency of microwave heating at the largest currently accessible scale in commercial microwave reactors (∼1−3 L). The…”
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Scaling-Out Pharmaceutical Reactions in an Automated Stop-Flow Microwave Reactor by Moseley, Jonathan D, Woodman, Emily K

“…Six pharmaceutically relevant reactions were assessed for scale-out in an automated stop-flow microwave reactor. Daily through-puts of between 50 and 250 g…”
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A Commercial Continuous Flow Microwave Reactor Evaluated for Scale-Up by Bergamelli, Fabio, Iannelli, Mauro, Marafie, Jameel A, Moseley, Jonathan D

“…Six pharmaceutically relevant reactions covering a range of physical parameters have been investigated in a commercially available microwave flow reactor. The…”
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Newman-Kwart Rearrangement of O-Aryl Thiocarbamates: Substantial Reduction in Reaction Temperatures through Palladium Catalysis by Harvey, Jeremy N, Jover, Jesús, Lloyd-Jones, Guy C, Moseley, Jonathan D, Murray, Paul, Renny, Joseph S

“…Much cooler: The development of a catalyst for the Newman–Kwart rearrangement allows an escape from the harsh thermal conditions of the standard uncatalyzed…”
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Scale-Up of Microwave-Assisted Reactions in a Multimode Bench-Top Reactor by Dallinger, Doris, Lehmann, Hansjörg, Moseley, Jonathan D, Stadler, Alexander, Kappe, C. Oliver

“…An evaluation of a new bench-top microwave batch reactor that uses a single 1 L reaction vessel is presented. Several microwave-assisted organic reactions have…”
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A mild robust generic protocol for the Suzuki reaction using an air stable catalyst by Moseley, Jonathan D., Murray, Paul M., Turp, Edward R., Tyler, Simon N.G., Burn, Ross T.

“…A mild but robust procedure has been developed as a first pass generic protocol for the Suzuki–Miyaura reaction. The protocol employs an air stable palladium…”
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A Comparison of Commercial Microwave Reactors for Scale-Up within Process Chemistry by Moseley, Jonathan D, Lenden, Philip, Lockwood, Mark, Ruda, Katinka, Sherlock, Jon-Paul, Thomson, Anthony D, Gilday, John P

“…Seven commercially available microwave reactors designed for limited scale-up have been investigated using a highly reliable and robust reaction (the…”
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The application of stop-flow microwave technology to scaling-out SNAr reactions using a soluble organic base by Marafie, Jameel A, Moseley, Jonathan D

“…A model S(N)Ar reaction which gives a range of substituted diaryl ethers has been re-developed to function with the soluble organic base DBU in the place of…”
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The Newman−Kwart Rearrangement:  A Microwave Kinetic Study by Gilday, John P., Lenden, Philip, Moseley, Jonathan D., Cox, Brian G.

“…The kinetic profile of the Newman−Kwart rearrangement has been evaluated using microwave heating. After first demonstrating equivalence between conventional…”
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Kepner-Tregoe Decision Analysis as a Tool to Aid Route Selection. Part 1 by Parker, Jeremy S, Moseley, Jonathan D

“…Kepner-Tregoe Decision Analysis is a logic-based tool that has been used by AstraZeneca to prioritise the investigation of alternative routes to drug…”
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Selective hydrogenation catalyst made via heat-processing of biogenic Pd nanoparticles and novel ‘green’ catalyst for Heck coupling using waste sulfidogenic bacteria by Mikheenko, Iryna P., Bennett, James A., Omajali, Jacob B., Walker, Marc, Johnson, D. Barrie, Grail, Barry M., Wong-Pascua, David, Moseley, Jonathan D., Macaskie, Lynne E.

“…A heterogeneous Pd catalyst, biologically-mineralized palladium nanoparticles (bio-Pd), was synthesized using sulfidogenic bacteria which reduced soluble…”
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Ligand and solvent selection in challenging catalytic reactions by Moseley, Jonathan D, Murray, Paul M

“…Transition metal‐catalysed reactions are often strongly dependent on ligand and selection, among other factors, which makes discovering the ideal…”
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Beyond the Numbers: Charting Chemical Reaction Space by Murray, Paul M, Tyler, Simon N. G, Moseley, Jonathan D

“…We present here an informed estimate of the millions of parameter settings that might be required to optimise one typical transition-metal-catalysed reaction…”
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Concise Xanthine Synthesis through a Double‐Amidination Reaction of a 6‐Chlorouracil with Amidines using Base‐Metal Catalysis by Morel, Bénédicte, Franck, Philippe, Bidange, Johan, Sergeyev, Sergey, Smith, Dan A., Moseley, Jonathan D., Maes, Bert U. W.

“…A new and concise route towards xanthines through a double‐amidination reaction is described; consecutive intermolecular C−Cl and intramolecular oxidative C−H…”
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A high temperature investigation using microwave synthesis for electronically and sterically disfavoured substrates of the Newman–Kwart rearrangement by Moseley, Jonathan D., Lenden, Philip

“…Electronically deactivated and/or sterically hindered substrates undergo the Newman–Kwart rearrangement (NKR) at around 300 °C, beyond the range of most…”
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The Molecularity of the Newman−Kwart Rearrangement by Burns, Matthew, Lloyd-Jones, Guy C, Moseley, Jonathan D, Renny, Joseph S

“…It was recently reported that the venerable Newman−Kwart rearrangement (1→2) proceeds via mixed first- and second-order kinetics. Prior to this, the…”
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Development of an Enantioselective, Kilogram-Scale, Rhodium-Catalysed 1,4-Addition by Brock, Sally, Hose, David R. J, Moseley, Jonathan D, Parker, Alexandra J, Patel, Ian, Williams, Andrew J

“…A rhodium-catalysed 1,4-addition of an arylboron species to an α,β-unsaturated ester was the key chirality-inducing step in the synthesis of an API. We…”
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The Newman–Kwart rearrangement re-evaluated by microwave synthesis by Moseley, Jonathan D., Sankey, Rosalind F., Tang, Olivier N., Gilday, John P.

“…The Newman–Kwart rearrangement (NKR) has been re-evaluated by microwave heating. Microwave technology has proven to be ideal for investigating this high…”
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A New Approach to the Rapid Parallel Development of Four Neurokinin Antagonists. Part 3. Assembly of Neurokinin Antagonists by Parker, Jeremy S, Bowden, Sharon A, Firkin, Catherine R, Moseley, Jonathan D, Murray, Paul M, Welham, Matthew J, Wisedale, Richard, Young, Maureen J, Moss, William O

“…Four neurokinin antagonists were assembled using a rapid parallel development approach. Research Department processes were scaled up if process safety and…”
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Energy Efficiency of Conventionally-Heated Pilot Plant Reactors Compared with Microwave Reactors by Godwin, Darryl R, Lawton, Simon J, Moseley, Jonathan D, Welham, Matthew J, Weston, Neil P

“…We report on the energy usage required for one organic reaction in two small pilot plant scale reactors of different vessel designs (both 50 L) conducted in a…”
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