Search Results - "Mosedale, David E."

Proteostasis is adaptive: Balancing chaperone holdases against foldases by de Graff, Adam Mr, Mosedale, David E, Sharp, Tilly, Dill, Ken A, Grainger, David J

“…Because a cell must adapt to different stresses and growth rates, its proteostasis system must too. How do cells detect and adjust proteome folding to…”
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Huntington disease patients and transgenic mice have similar pro-catabolic serum metabolite profiles by Underwood, Benjamin R., Broadhurst, David, Dunn, Warwick B., Ellis, David I., Michell, Andrew W., Vacher, Coralie, Mosedale, David E., Kell, Douglas B., Barker, Roger A., Grainger, David J., Rubinsztein, David C.

“…There has been considerable progress recently towards developing therapeutic strategies for Huntington's disease (HD), with several compounds showing…”
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Neuroprotection in Ischemia-Reperfusion Injury: An Antiinflammatory Approach Using a Novel Broad-Spectrum Chemokine Inhibitor by Beech, John S., Reckless, Jill, Mosedale, David E., Grainger, David J., Williams, Steve C. R., Menon, David K.

“…Cerebral ischemia–reperfusion injury is associated with a developing inflammatory response with pathologic contributions from vascular leukocytes and…”
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TGF-β in blood: a complex problem by Grainger, David J, Mosedale, David E, Metcalfe, James C

“…The cytokine transforming growth factor-β (TGF-β) was initially purified from human platelets, a rich source of this protein. In addition to platelets, TGF-β1…”
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Rapid and noninvasive diagnosis of the presence and severity of coronary heart disease using 1H-NMR-based metabonomics by Brindle, Joanne T, Antti, Henrik, Holmes, Elaine, Tranter, George, Nicholson, Jeremy K, Bethell, Hugh W L, Clarke, Sarah, Schofield, Peter M, McKilligin, Elaine, Mosedale, David E, Grainger, David J

“…Although a wide range of risk factors for coronary heart disease have been identified from population studies, these measures, singly or in combination, are…”
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Circulating levels of MCP-1 and eotaxin are not associated with presence of atherosclerosis or previous myocardial infarction by Mosedale, David E., Smith, Duncan J., Aitken, Sri, Schofield, Peter M., Clarke, Sarah C., McNab, Duncan, Goddard, Hester, Gale, Catharine R., Martyn, Christopher N., Bethell, Hugh W.L., Barnard, Caryl, Hayns, Sarah, Nugent, Claire, Panicker, Annik, Grainger, David J.

“…The chemokines are a family of signalling proteins that participate in regulation of the immune system and have been implicated in the pathogenesis of vascular…”
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A pattern of anti-carbohydrate antibody responses present in patients with advanced atherosclerosis by Mosedale, David E., Chauhan, Anoop, Schofield, Peter M., Grainger, David J.

“…We have previously shown that an antibody pool present in normal human serum binds cytokine receptors in vitro and may therefore interfere with assays that…”
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Measurement of human serum IgD levels by Overed-Sayer, Catherine L, Mosedale, David E, Goodall, Margaret, Grainger, David J

“…This unit describes an ELISA for the quantitative measurement of IgD levels in human serum. The ELISA is highly specific and sensitive, with a minimum…”
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A new sensitive and specific enzyme-linked immunosorbent assay for IgD by Mosedale, David E., Sandhu, Manjinder S., Luan, Jian'an, Goodall, Margaret, Grainger, David J.

“…We have developed a new highly specific ELISA for IgD, and then used it to measure levels of circulating IgD in the serum of 480 un-selected patients from the…”
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Dietary fat and reduced levels of TGFβ1 act synergistically to promote activation of the vascular endothelium and formation of lipid lesions by Grainger, David J., Mosedale, David E., Metcalfe, James C., Böttinger, Erwin P.

“…Transforming growth factor-β (TGFβ) has a wide range of activities on vascular cells and inflammatory cells, suggesting it may have different functions during…”
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Transforming growth factor-beta dynamically regulates vascular smooth muscle differentiation in vivo by Grainger, D J, Metcalfe, J C, Grace, A A, Mosedale, D E

“…Variations in the levels of smooth muscle-specific isoforms of contractile proteins have been reported to occur in many different vascular diseases. However,…”
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An antibody present in normal human serum inhibits the binding of cytokines to their receptors in an in vitro system by MOSEDALE, David E., GRAINGER, David J.

“…The presence of active transforming growth factor-β (TGF-β) in serum has not been widely accepted. In particular, although at least five studies have concluded…”
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Rapid and noninvasive diagnosis of the presence and severity of coronary heart disease using 1H-NMR-based metabonomics by Brindle, Joanne T, Antti, Henrik, Holmes, Elaine, Tranter, George, Nicholson, Jeremy K, Bethell, Hugh W.L, Clarke, Sarah, Schofield, Peter M, McKilligin, Elaine, Mosedale, David E, Grainger, David J

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Corrigendum: Rapid and noninvasive diagnosis of the presence and severity of coronary heart disease using 1H-NMR-based metabonomics by Brindle, Joanne T, Antti, Henrik, Holmes, Elaine, Tranter, George, Nicholson, Jeremy K, Hugh W.L. Bethell, Clarke, Sarah, Schofield, Peter M, McKilligin, Elaine, Mosedale, David E, Grainger, David J

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Erratum: Rapid and noninvasive diagnosis of the presence and severity of coronary heart disease using 1H-NMR-based metabonomics by Brindle, Joanne T., Antti, Henrik, Holmes, Elaine, Tranter, George, Nicholson, Jeremy K., Bethell, Hugh W.L., Clarke, Sarah, Schofield, Peter M., McKilligin, Elaine, Mosedale, David E., Grainger, David J.

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Rapid and noninvasive diagnosis of the presence and severity of coronary heart disease using 1 H-NMR-based metabonomics by Grainger, David J, Brindle, Joanne T, Antti, Henrik, Holmes, Elaine, Tranter, George, Nicholson, Jeremy K, Bethell, Hugh W.L, Clarke, Sarah, Schofield, Peter M, McKilligin, Elaine, Mosedale, David E

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An antibody present in normal human serum inhibits the binding of cytokines to their receptors in an in vitro system by Mosedale, D E, Grainger, D J

“…The presence of active transforming growth factor-beta (TGF-beta) in serum has not been widely accepted. In particular, although at least five studies have…”
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Active and acid-activatable TGF-β in human sera, platelets and plasma by Grainger, David J., Mosedale, David E., Metcalfe, James C., Weissberg, Peter L., Kemp, Paul R.

“…Assays which measure active and latent forms of transforming growth factor β (TGF-β) separately in human serum and plasma are required to investigate the…”
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Optimization of immunofluorescence methods by quantitative image analysis by Mosedale, DE, Metcalfe, JC, Grainger, DJ

“…There is a growing trend towards the objective quantification of immunohistochemical staining. However, quantification has not been used previously to optimize…”
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Transforming growth factor-β dynamically regulates vascular smooth muscle differentiation in vivo by Grainger, David J., Metcalfe, James C., Grace, Andrew A., Mosedale, David E.

“…Variations in the levels of smooth muscle-specific isoforms of contractile proteins have been reported to occur in many different vascular diseases. However,…”
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