Search Results - "Moschos, S."

Next steps in immuno-oncology: enhancing antitumor effects through appropriate patient selection and rationally designed combination strategies by Salama, A.K.S., Moschos, S.J.

“…Cancers escape immune surveillance via distinct mechanisms that involve central (negative selection within the thymus) or peripheral (lack of costimulation,…”
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Safety and efficacy of decitabine in combination with temozolomide in metastatic melanoma: a phase I/II study and pharmacokinetic analysis by Tawbi, H.A., Beumer, J.H., Tarhini, A.A., Moschos, S., Buch, S.C., Egorin, M.J., Lin, Y., Christner, S., Kirkwood, J.M.

“…Temozolomide (TMZ) is widely used for chemotherapy of metastatic melanoma. We hypothesized that epigenetic modulators will reverse chemotherapy resistance, and…”
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SAGE and antibody array analysis of melanoma-infiltrated lymph nodes: identification of Ubc9 as an important molecule in advanced-stage melanomas by MOSCHOS, S. J, SMITH, A. P, MANDIC, M, ATHANASSIOU, C, WATSON-HURST, K, JUKIC, D. M, EDINGTON, H. D, KIRKWOOD, J. M, BECKER, D

“…Although patients diagnosed with melanoma of </= 1.00 mm thickness have a relatively good cure rate, the prognosis for patients with locally advanced and…”
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Predicting oligonucleotide therapeutic efficacy at the population level by Theotokis, Pantazis I, Usher, L, Kortschak, C K, Schwalbe, Ed, Moschos, S A

“…DNA-directed RNA interfering (RNAi) mediators that follow the classic Watson-Crick base pairing to bind to their molecular targets and exert their silencing…”
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NCI 9922: Phase II study of ibrutinib in treatment-refractory distant metastatic cutaneous melanoma (DMCM) by Moschos, S.J., Eroglu, Z., Khushalani, N.I., Kendra, K.L., Ansstas, G., In, G.K., Wang, P., Liu, G., Collichio, F.A., Arrowood, C.C., Reed, J.E., Garrett-Mead, N., Thomas, N.E., Ollila, D.W., Ivy, S.P., Ivanova, A., Dees, E.C., Abbruzzese, J.L.

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Inhibition of DNA repair with MGMT pseudosubstrates: phase I study of lomeguatrib in combination with dacarbazine in patients with advanced melanoma and other solid tumours by Tawbi, H A, Villaruz, L, Tarhini, A, Moschos, S, Sulecki, M, Viverette, F, Shipe-Spotloe, J, Radkowski, R, Kirkwood, J M

“…Background: The DNA repair protein O 6 -methylguanine-DNA methyltransferase (MGMT) reverses the O 6 -methylguanine ( O 6 -meG) lesion induced by dacarbazine…”
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Cell-penetrating-peptide-mediated siRNA lung delivery by Moschos, S A, Williams, A E, Lindsay, M A

“…The therapeutic application of siRNA (short interfering RNA) shows promise as an alternative approach to small-molecule inhibitors for the treatment of human…”
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Leptin: in search of role(s) in human physiology and pathophysiology by Mantzoros, Christos S., Moschos, Stergios J.

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Adjuvant synergy: The effects of nasal coadministration of adjuvants by Moschos, SA, Bramwell, VW, Somavarapu, S, Alpar, HO

“…Modern peptide and protein subunit vaccines suffer from poor immunogenicity and require the use of adjuvants. However, none of the currently licensed adjuvants…”
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Modulating the adjuvanticity of alum by co-administration of muramyl di-peptide (MDP) or Quil-A by Moschos, Sterghios A., Bramwell, Vincent W., Somavarapu, Satyanarayna, Alpar, H. Oya

“…The characterization of the immunological cascades of the innate immune system activated by pathogen associated molecular patterns (PAMP) recognized by pattern…”
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Safety and Efficacy of Stereotactic Radiosurgery with Concurrent Targeted Systemic Therapy for Brain Metastases by Hall, J., Wang, K., Lui, K.P., Darawsheh, R., Shumway, J.W., Carey, L.A., Hayes, K. Reeder, Lee, C.B., Moschos, S., Sengupta, S., Chaudhary, R., Yogendran, L., Struve, T.D., Vatner, R.E., Pater, L.E., Breneman, J.C., Weiner, A.A., Shen, C.

“…Data describing the safety and efficacy of central nervous system (CNS)-active targeted systemic therapies in combination with stereotactic radiosurgery (SRS,…”
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Leptin in Immunology by Matarese, Giuseppe, Moschos, Stergios, Mantzoros, Christos S

“…Leptin is an adipokine which conveys information on energy availability. In humans, leptin influences energy homeostasis and regulates neuroendocrine function…”
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Stereotactic Radiotherapy with Immunotherapy for Treatment of Brain Metastases: Optimal Timing and Fractionation to Improve Disease Control and Minimize Toxicity by Hall, J., Lui, K.P., Tan, X., Shumway, J.W., Collichio, F., Moschos, S., Sengupta, S., Chaudhary, R., Quinsey, C., Jaikumar, S., Forbes, J., Andaluz, N., Zuccarello, M., Struve, T.D., Vatner, R.E., Pater, L.E., Breneman, J.C., Weiner, A.A., Wang, K., Shen, C.

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Expression of HLA-DR is reduced in tumor infiltrating immune cells (TIICs) and regional lymph nodes of non-small-cell lung carcinomas. A putative mechanism of tumor-induced immunosuppression? by Foukas, P G, Tsilivakos, V, Zacharatos, P, Mariatos, G, Moschos, S, Syrianou, A, Asimacopoulos, P J, Bramis, J, Fotiadis, C, Kittas, C, Gorgoulis, V G

“…Deregulation of MHC class II molecules consists of a favorable mechanism of tumor evasion from immune surveillance. Among these molecules, HLA-DR antigens are…”
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Leptin and reproduction: a review by Moschos, Stergios, Chan, Jean L, Mantzoros, Christos S

“…To review recent advances in understanding the role of leptin in the physiology and pathophysiology of reproduction, with a focus on relevant clinical…”
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OC-0513: Radiation necrosis following stereotactic RT and immunotherapy for melanoma brain metastases by Kaidar-Person, O., Zagar, T., Deal, A., Moschos, S., Ewend, M., Sasaki-Adams, D., Lee, C., Collichio, F., Fried, D., Marks, L., Chera, B.

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1268PNCI 9922: Phase II study of ibrutinib in treatment-refractory distant metastatic cutaneous melanoma (DMCM) by Moschos, S J, Eroglu, Z, Khushalani, N I, Kendra, K L, Ansstas, G, In, G K, Wang, P, Liu, G, Collichio, F A, Arrowood, C C, Reed, J E, Garrett-Mead, N, Thomas, N E, Ollila, D W, Ivy, S P, Ivanova, A, Dees, E C, Abbruzzese, J L

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Safety and Immunogenicity of Vaccination With MART-1 (26-35, 27L), gp100 (209-217, 210M), and Tyrosinase (368-376, 370D) In Adjuvant With PF-3512676 and GM-CSF In Metastatic Melanoma by TARHINI, Ahmad A, SIYANG LENG, MOSCHOS, Stergios J, YAN YIN, SANDER, Cindy, YAN LIN, GOODING, William E, KIRKWOOD, John M

“…The effectivenes of cancer vaccines in inducing CD8(+) T-cell responses remains a challenge, resulting in a need for testing more potent adjuvants. Our…”
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Helper Activity of Natural Killer Cells During the Dendritic Cell-mediated Induction of Melanoma-specific Cytotoxic T Cells by WONG, Jeffrey L, MAILLIARD, Robbie B, MOSCHOS, Stergios J, EDINGTON, Howard, LOTZE, Michael T, KIRKWOOD, John M, KALINSKI, Pawel

“…Natural killer (NK) cells have been shown to mediate important immunoregulatory "helper" functions in addition to their cytolytic activity. In particular, NK…”
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Effects of Acute and Chronic Administration of the Melanocortin Agonist MTII in Mice With Diet-Induced Obesity by PIERROZ, Dominique D, ZIOTOPOULOU, Mary, UNGSUNAN, Linda, MOSCHOS, Stergios, FLIER, Jeffrey S, MANTZOROS, Christos S

“…Effects of Acute and Chronic Administration of the Melanocortin Agonist MTII in Mice With Diet-Induced Obesity Dominique D. Pierroz , Mary Ziotopoulou , Linda…”
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