Search Results - "Moschella, Antonino"

Trop‐2 cleavage by ADAM10 is an activator switch for cancer growth and metastasis by Trerotola, Marco, Guerra, Emanuela, Ali, Zeeshan, Aloisi, Anna Laura, Ceci, Martina, Simeone, Pasquale, Acciarito, Angela, Zanna, Paola, Vacca, Giovanna, D'Amore, Antonella, Boujnah, Khouloud, Garbo, Valeria, Moschella, Antonino, Lattanzio, Rossano, Alberti, Saverio

“…Trop-2 is a transmembrane signal transducer that can induce cancer growth. Using antibody targeting and N-terminal Edman degradation, we show here that Trop-2…”
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Trop-2 induces ADAM10-mediated cleavage of E-cadherin and drives EMT-less metastasis in colon cancer by Guerra, Emanuela, Trerotola, Marco, Relli, Valeria, Lattanzio, Rossano, Tripaldi, Romina, Vacca, Giovanna, Ceci, Martina, Boujnah, Khouloud, Garbo, Valeria, Moschella, Antonino, Zappacosta, Romina, Simeone, Pasquale, de Lange, Robert, Weidle, Ulrich H., Rotelli, Maria Teresa, Picciariello, Arcangelo, Depalo, Raffaella, Querzoli, Patrizia, Pedriali, Massimo, Bianchini, Enzo, Angelucci, Domenico, Pizzicannella, Giuseppe, Di Loreto, Carla, Piantelli, Mauro, Antolini, Laura, Sun, Xiao-Feng, Altomare, Donato F., Alberti, Saverio

“…We recently reported that activation of Trop-2 through its cleavage at R87-T88 by ADAM10 underlies Trop-2–driven progression of colon cancer. However, the…”
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Pharmacogenetics in Italy: current landscape and future prospects by Floris, Matteo, Moschella, Antonino, Alcalay, Myriam, Montella, Annalaura, Tirelli, Matilde, Fontana, Laura, Idda, Maria Laura, Guarnieri, Paolo, Capasso, Mario, Mammì, Corrado, Nicoletti, Paola, Miozzo, Monica

“…Pharmacogenetics investigates sequence of genes that affect drug response, enabling personalized medication. This approach reduces drug-induced adverse…”
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A novel case of 16q22.3 duplication syndrome in a child with overgrowth: case report and literature review by Moschella, Antonino, Capra, Anna Paola, Corica, Domenico, Pepe, Giorgia, Di Tommaso, Silvia, Sallicandro, Ester, Wasniewska, Malgorzata G, Briuglia, Silvana, Aversa, Tommaso

“…Distal chromosome 16 duplication syndrome (also known as 16q partial trisomy) is a very rare genetic disorder recently described in few clinical reports. 16q…”
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Phylogenetic conservation of Trop-2 across species-rodent and primate genomics model anti-Trop-2 therapy for pre-clinical benchmarks by Guerra, Emanuela, Trerotola, Marco, Relli, Valeria, Lattanzio, Rossano, Boujnah, Khouloud, Travali, Nicole, Moschella, Antonino, Todaro, Paolo, Pierdomenico, Laura, Di Pietro, Roberta, Tinari, Nicola, Alberti, Saverio

“…A phylogenetic conservation analysis of Trop-2 across vertebrate species showed a high degree of sequence conservation, permitting to explore multiple models…”
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Abstract 2608: Hu2G10 antibody-drug conjugates selectively target cleaved-activated Trop-2 in cancer cells and show therapeutic efficacy against multiple human cancers by Alberti, Saverio, Trerotola, Marco, Moschella, Antonino, Giavazzi, Raffaella, Guerra, Emanuela

“…Abstract Trop-2 is a transmembrane calcium signal transducer which activates growth-signaling networks that converge on Akt, ERK, Cyclin D1, NFkB (1). Trop-2…”
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Abstract 2589: TROP2 gene copy number variations are a hallmark of glioblastoma and MEN-2A cancers by Alberti, Saverio, Trerotola, Marco, Moschella, Antonino, Guerra, Emanuela

“…Abstract TROP2 mutations are not required to trigger activation of tumor growth and metastasis. However, expression of Trop-2 is affected by DNA methylation in…”
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Abstract 2851: Trop-2 inactivates E-cadherin for metastatic diffusion in the absence of EMT by Alberti, Saverio, Guerra, Emanuela, Relli, Valeria, Lattanzio, Rossano, Ceci, Martina, Boujnah, Khouloud, Garbo, Valeria, Moschella, Antonino, Altomare, donato F., Depalo, Raffaella, Trerotola, Marco

“…Abstract Trop-2 is a type I transmembrane glycoprotein, which is overexpressed in the majority of carcinomas, where it drives tumor cell proliferation. In its…”
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Abstract PD15-04: Trop-2 inactivation of E-cadherin drives triple negative breast cancer relapse by Alberti, Saverio, Trerotola, Marco, Relli, Valeria, Lattanzio, Rossano, Ceci, Martina, Boujnah, Khouloud, Garbo, Valeria, Moschella, Antonino, Querzoli, Patrizia, Pedriali, Massimo, Antolini, Laura, Guerra, Emanuela

“…Abstract Hundreds of proteins/genes have been linked to the metastatic phenotype. However, consistent markers of tumour aggressiveness and metastatic potential…”
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Abstract 346: Trop-2 induces apoptosis via transcriptional activation of TRAIL, FAS-FASL, CD40-TNFRSF5 by Alberti, Saverio, Guerra, Emanuela, Moschella, Antonino, Ceci, Martina, Pantalone, Ludovica, Di Pietro, Roberta, Trerotola, Marco

“…Abstract Trop-2 is a transmembrane signal transducer that activates cancer growth and metastatic diffusion (1). However, this does not occur in all tumor…”
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A deterministic code for transcription factor-DNA recognition through computation of binding interfaces by Trerotola, Marco, Antolini, Laura, Beni, Laura, Guerra, Emanuela, Spadaccini, Mariano, Verzulli, Damiano, Moschella, Antonino, Alberti, Saverio

“…Abstract The recognition code between transcription factor (TF) amino acids and DNA bases remains poorly understood. Here, the determinants of TF amino…”
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Abstract 2550: Growth factor-induced cell membrane macroplatforms drive protein kinase signaling for transformed cell growth by Alberti, Saverio, Relli, Valeria, Tripaldi, Romina, Simeone, Pasquale, Guerra, Emanuela, Sacchetti, Andrea, Ciufici, Paolo, Moschella, Antonino, Caiolfa, Valeria, Zamai, Moreno, Trerotola, Marco

“…Abstract Nanoscopic, millisecond-lasting membrane platforms are modeled to constitute main functional signaling units. However, multiple signaling events in…”
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