Search Results - "Mosbacher, J"

Five decades of terrestrial and freshwater research at Ny-Ålesund, Svalbard by Pedersen, Å.Ø., Convey, P., Newsham, K.K., Mosbacher, J.B., Fuglei, E., Ravolainen, V., Hansen, B.B., Jensen, T.C., Augusti, A., Biersma, E.M., Cooper, E.J., Coulson, S.J., Gabrielsen, G.W., Gallet, J.C., Karsten, U., Kristiansen, S.M., Svenning, M.M., Tveit, A.T., Uchida, M., Baneschi, I., Calizza, E., Cannone, N., de Goede, E.M., Doveri, M., Elster, J., Giamberini, M.S., Hayashi, K., Lang, S.I., Lee, Y.K., Nakatsubo, T., Pasquali, V., Paulsen, I.M.G., Pedersen, C., Peng, F., Provenzale, A., Pushkareva, E., Sandström, C.A.M., Sklet, V., Stach, A., Tojo, M., Tytgat, B., Tømmervik, H., Velazquez, D., Verleyen, E., Welker, J.M., Yao, Y.-F., Loonen, M.J.J.E.

“…For more than five decades, research has been conducted at Ny-Ålesund, in Svalbard, Norway, to understand the structure and functioning of High-Arctic…”
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GABA(B)-receptor subtypes assemble into functional heteromeric complexes by Kaupmann, K, Malitschek, B, Schuler, V, Heid, J, Froestl, W, Beck, P, Mosbacher, J, Bischoff, S, Kulik, A, Shigemoto, R, Karschin, A, Bettler, B

“…B-type receptors for the neurotransmitter GABA (gamma-aminobutyric acid) inhibit neuronal activity through G-protein-coupled second-messenger systems, which…”
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A Molecular Determinant for Submillisecond Desensitization in Glutamate Receptors by Mosbacher, J., Schoepfer, R., Monyer, H., Burnashev, N., Seeburg, P. H., Ruppersberg, J. P.

“…The decay of excitatory postsynaptic currents in central neurons mediated by $\alpha$-amino-3-hydroxy-5-methyl-4-isoxazole-propionate (AMPA) receptors is…”
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ANKTM1, a TRP-like Channel Expressed in Nociceptive Neurons, Is Activated by Cold Temperatures by Story, Gina M., Peier, Andrea M., Reeve, Alison J., Eid, Samer R., Mosbacher, Johannes, Hricik, Todd R., Earley, Taryn J., Hergarden, Anne C., Andersson, David A., Hwang, Sun Wook, McIntyre, Peter, Jegla, Tim, Bevan, Stuart, Patapoutian, Ardem

“…Mammals detect temperature with specialized neurons in the peripheral nervous system. Four TRPV-class channels have been implicated in sensing heat, and one…”
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Control of Kinetic Properties of AMPA Receptor Channels by Nuclear RNA Editing by Lomeli, Hilda, Mosbacher, Johannes, Melcher, Thorsten, Höger, Thomas, Jörg R. P. Geiger, Kuner, Thomas, Monyer, Hannah, Higuchi, Miyoko, Bach, Alfred, Seeburg, Peter H.

“…AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) receptor channels mediate the fast component of excitatory postsynaptic currents in the central…”
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Voltage-dependent membrane displacements measured by atomic force microscopy by Mosbacher, J, Langer, M, Hörber, J K, Sachs, F

“…Cells use polar molecules in the membrane to sense changes in the transmembrane potential. The opening of voltage-gated ion channels and membrane bending due…”
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Molecular structure and physiological functions of GABA(B) receptors by Bettler, Bernhard, Kaupmann, Klemens, Mosbacher, Johannes, Gassmann, Martin

“…GABA(B) receptors are broadly expressed in the nervous system and have been implicated in a wide variety of neurological and psychiatric disorders. The cloning…”
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P2Y receptor subtypes differentially couple to inwardly-rectifying potassium channels by Mosbacher, J, Maier, R, Fakler, B, Glatz, A, Crespo, J, Bilbe, G

“…Subtypes of P2Y receptors are well characterized with respect to their agonist profile but little is known about differences in their intracellular signalling…”
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A look at membrane patches with a scanning force microscope by Hörber, J.K., Mosbacher, J., Häberle, W., Ruppersberg, J.P., Sakmann, B.

“…We combined scanning force microscopy with patch-clamp techniques in the same experimental setup and obtained images of excised membrane patches spanning the…”
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Positive allosteric modulation of native and recombinant gamma-aminobutyric acid(B) receptors by 2,6-Di-tert-butyl-4-(3-hydroxy-2,2-dimethyl-propyl)-phenol (CGP7930) and its aldehyde analog CGP13501 by Urwyler, S, Mosbacher, J, Lingenhoehl, K, Heid, J, Hofstetter, K, Froestl, W, Bettler, B, Kaupmann, K

“…The compounds CGP7930 [2,6-Di-tert-butyl-4-(3-hydroxy-2,2-dimethyl-propyl)-phenol] and its close analog CGP13501 were identified as positive modulators of…”
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Preparation, Antiepileptic Activity, and Cardiovascular Safety of Dihydropyrazoles as Brain-Penetrant T‑Type Calcium Channel Blockers by Remen, Lubos, Bezençon, Olivier, Simons, Lloyd, Gaston, Rick, Downing, Dennis, Gatfield, John, Roch, Catherine, Kessler, Melanie, Mosbacher, Johannes, Pfeifer, Thomas, Grisostomi, Corinna, Rey, Markus, Ertel, Eric A, Moon, Richard

“…A series of dihydropyrazole derivatives was developed as potent, selective, and brain-penetrating T-type calcium channel blockers. An optimized derivative,…”
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Processing of GABABR1 in Heterologous Expression Systems by MOSBACHER, J., KAUPMANN, K., SCHULER, V., RISTIG, D., STRUCKMEYER, K., PFAFF, T., KARSCHIN, A., POZZA, M. F., BETTLER, B.

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Epilepsy, hyperalgesia, impaired memory, and loss of pre- and postsynaptic GABA(B) responses in mice lacking GABA(B(1)) by Schuler, V, Lüscher, C, Blanchet, C, Klix, N, Sansig, G, Klebs, K, Schmutz, M, Heid, J, Gentry, C, Urban, L, Fox, A, Spooren, W, Jaton, A L, Vigouret, J, Pozza, M, Kelly, P H, Mosbacher, J, Froestl, W, Käslin, E, Korn, R, Bischoff, S, Kaupmann, K, van der Putten, H, Bettler, B

“…GABA(B) (gamma-aminobutyric acid type B) receptors are important for keeping neuronal excitability under control. Cloned GABA(B) receptors do not show the…”
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Location of studies and evidence of effects of herbivory on Arctic vegetation: a systematic map by Soininen, E. M, Barrio, I. C, Bjarkås, R, Björnsdóttir, K, Ehrich, D, Hopping, K. A, Kaarlejärvi, E, Kolstad, A. L, Abdulmanova, S, Björk, R. G, Bueno, C. G, Eischeid, I, Finger-Higgens, R, Forbey, J. S, Gignac, C, Gilg, O, den Herder, M, Holm, H. S, Hwang, B. C, Jepsen, J. U, Kamenova, S, Kater, I, Koltz, A. M, Kristensen, J. A, Little, C. J, Macek, P, Mathisen, K. M, Metcalfe, D. B, Mosbacher, J. B, Mörsdorf, M, Park, T, Propster, J. R, Roberts, A. J, Serrano, E, Spiegel, M. P, Tamayo, M, Tuomi, M. W, Verma, M, Vuorinen, K. E. M, Väisänen, M, van der Wal, R, Wilcots, M. E, Yoccoz, N. G, Speed, J. D. M

“…Abstract Background Herbivores modify the structure and function of tundra ecosystems. Understanding their impacts is necessary to assess the responses of…”
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Specific gamma-hydroxybutyrate-binding sites but loss of pharmacological effects of gamma-hydroxybutyrate in GABA(B)(1)-deficient mice by Kaupmann, Klemens, Cryan, John F, Wellendorph, Petrine, Mombereau, Cedric, Sansig, Gilles, Klebs, Klaus, Schmutz, Markus, Froestl, Wolfgang, van der Putten, Herman, Mosbacher, Johannes, Bräuner-Osborne, Hans, Waldmeier, Peter, Bettler, Bernhard

“…gamma-Hydroxybutyrate (GHB), a metabolite of gamma-aminobutyric acid (GABA), is proposed to function as a neurotransmitter or neuromodulator…”
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C-terminal interaction is essential for surface trafficking but not for heteromeric assembly of GABA(b) receptors by Pagano, A, Rovelli, G, Mosbacher, J, Lohmann, T, Duthey, B, Stauffer, D, Ristig, D, Schuler, V, Meigel, I, Lampert, C, Stein, T, Prezeau, L, Blahos, J, Pin, J, Froestl, W, Kuhn, R, Heid, J, Kaupmann, K, Bettler, B

“…Assembly of fully functional GABA(B) receptors requires heteromerization of the GABA(B(1)) and GABA(B(2)) subunits. It is thought that GABA(B(1)) and…”
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Control of Electrical Activity in Central Neurons by Modulating the Gating of Small Conductance Ca2+-activated K+ Channels by Pedarzani, Paola, Mosbacher, Johannes, Rivard, Andre, Cingolani, Lorenzo A., Oliver, Dominik, Stocker, Martin, Adelman, John P., Fakler, Bernd

“…In most central neurons, action potentials are followed by an afterhyperpolarization (AHP) that controls firing pattern and excitability. The medium and slow…”
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Gamma-hydroxybutyrate is a weak agonist at recombinant GABA(B) receptors by Lingenhoehl, K, Brom, R, Heid, J, Beck, P, Froestl, W, Kaupmann, K, Bettler, B, Mosbacher, J

“…Gamma-hydroxybutyrate (GHB) is a neuromodulator with high affinity binding sites in the mammalian brain. However, the receptor for GHB has not yet been…”
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Coupling of human nicotinic acetylcholine receptors alpha 7 to calcium channels in GH3 cells by Feuerbach, Dominik, Lingenhöhl, Kurt, Dobbins, Peter, Mosbacher, Johannes, Corbett, Nicola, Nozulak, Joachim, Hoyer, Daniel

“…The neuronal nicotinic acetylcholine receptor alpha7 (nAChR alpha7) may be involved in cognitive deficits in Schizophrenia and Alzheimer's disease. A fast…”
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The anticonvulsant gabapentin (neurontin) does not act through gamma-aminobutyric acid-B receptors by Jensen, Anders A, Mosbacher, Johannes, Elg, Susanne, Lingenhoehl, Kurt, Lohmann, Tania, Johansen, Tommy N, Abrahamsen, Bjarke, Mattsson, Jan P, Lehmann, Anders, Bettler, Bernhard, Bräuner-Osborne, Hans

“…The actions of the anticonvulsant gabapentin [1-(aminomethyl)cyclohexaneacetic acid, Neurontin] have been somewhat enigmatic until recently, when it was…”
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