Search Results - "Morwick, Tina"

Understanding concentrated insulins: a systematic review of randomized controlled trials by Ovalle, Fernando, Segal, Alissa R., Anderson, John E., Cohen, Michael R., Morwick, Tina M., Jackson, Jeffrey A.

“…Objective: To compile, analyze, and summarize the literature on concentrated insulins (i.e. concentrations >100 units/mL) from randomized controlled trials and…”
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Dose Accuracy, Injection Force, and Usability Assessment of a New Half-Unit, Prefilled Insulin Pen by Kappes, Christopher M., Kershner, James R., Morwick, Tina M., Corrigan, Sheila M.

“…Background: This study examines the utility of the first prefilled, rapid-acting insulin pen that can be dialed in half-unit increments. Dose accuracy and…”
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Synthesis, SAR, and Series Evolution of Novel Oxadiazole-Containing 5‑Lipoxygenase Activating Protein Inhibitors: Discovery of 2‑[4-(3-{(R)‑1-[4-(2-Amino-pyrimidin-5-yl)-phenyl]-1-cyclopropyl-ethyl}-[1,2,4]oxadiazol-5-yl)-pyrazol-1-yl]‑N,N‑dimethyl-acetamide (BI 665915) by Takahashi, Hidenori, Riether, Doris, Bartolozzi, Alessandra, Bosanac, Todd, Berger, Valentina, Binetti, Ralph, Broadwater, John, Chen, Zhidong, Crux, Rebecca, De Lombaert, Stéphane, Dave, Rajvee, Dines, Jonathon A, Fadra-Khan, Tazmeen, Flegg, Adam, Garrigou, Michael, Hao, Ming-Hong, Huber, John, Hutzler, J. Matthew, Kerr, Steven, Kotey, Adrian, Liu, Weimin, Lo, Ho Yin, Loke, Pui Leng, Mahaney, Paige E, Morwick, Tina M, Napier, Spencer, Olague, Alan, Pack, Edward, Padyana, Anil K, Thomson, David S, Tye, Heather, Wu, Lifen, Zindell, Renee M, Abeywardane, Asitha, Simpson, Thomas

“…The synthesis, structure–activity relationship (SAR), and evolution of a novel series of oxadiazole-containing 5-lipoxygenase-activating protein (FLAP)…”
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Lilly Insulin Glargine Versus Lantus® in Insulin-Naïve and Insulin-Treated Adults with Type 2 Diabetes: A Randomized, Controlled Trial (ELEMENT 5) by Pollom, Robyn K., Ilag, Liza L., Lacaya, Lyndon B., Morwick, Tina M., Ortiz Carrasquillo, Ramón

“…Introduction This study compared the efficacy and safety of similar U-100 insulin glargine products, namely, Lilly insulin glargine (LY IGlar; Basaglar ® ) and…”
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Pim kinase inhibitors: a survey of the patent literature by Morwick, Tina

“…Pim kinases have recently emerged as targets of interest in oncology and immune regulation. Ongoing studies have identified a role for these proteins in cell…”
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A Practical Approach to the Synthesis of 2,4-Disubstituted Oxazoles from Amino Acids by Morwick, Tina, Hrapchak, Matt, DeTuri, Molly, Campbell, Scot

“…A new sequence for the synthesis of various 2,4-disubstituted oxazoles from α-amino acids is reported. The method is shown to be general and incorporates the…”
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Discovery of 2-Phenylamino-imidazo[4,5-h]isoquinolin-9-ones:  A New Class of Inhibitors of Lck Kinase by Snow, Roger J, Cardozo, Mario G, Morwick, Tina M, Busacca, Carl A, Dong, Yong, Eckner, Robert J, Jacober, Stephen, Jakes, Scott, Kapadia, Suresh, Lukas, Susan, Panzenbeck, Maret, Peet, Gregory W, Peterson, Jeffrey D, Prokopowicz, Anthony S, Sellati, Rosemarie, Tolbert, Robert M, Tschantz, Matt A, Moss, Neil

“…An imidazo[4,5-h]isoquinolin-7,9-dione (1) was identified as an adenosine 5‘-triphosphate competitive inhibitor of lck by high throughput screening. Initial…”
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Optimization of 2-Phenylaminoimidazo[4,5-h]isoquinolin-9-ones:  Orally Active Inhibitors of lck Kinase by Goldberg, Daniel R, Butz, Tanja, Cardozo, Mario G, Eckner, Robert J, Hammach, Abdelhakim, Huang, Jessica, Jakes, Scott, Kapadia, Suresh, Kashem, Mohammed, Lukas, Susan, Morwick, Tina M, Panzenbeck, Maret, Patel, Usha, Pav, Susan, Peet, Gregory W, Peterson, Jeffrey D, Prokopowicz, Anthony S, Snow, Roger J, Sellati, Rosemarie, Takahashi, Hidenori, Tan, Jonathan, Tschantz, Matt A, Wang, Xiao-Jun, Wang, Yong, Wolak, John, Xiong, Pla, Moss, Neil

“…The tyrosine kinase p56lck (lck) is essential for T cell activation; thus, inhibitors of lck have potential utility as autoimmune agents. Our initial…”
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Discovery and SAR of novel [1,6]Naphthyridines as potent inhibitors of spleen tyrosine kinase (SYK) by Cywin, Charles L, Zhao, Bao-Ping, McNeil, Daniel W, Hrapchak, Matt, Prokopowicz, Anthony S, Goldberg, Daniel R, Morwick, Tina M, Gao, Amy, Jakes, Scott, Kashem, Mohammed, Magolda, Ronald L, Soll, Richard M, Player, Mark R, Bobko, Mark A, Rinker, James, DesJarlais, Renee L, Winters, Michael P

“…The discovery of novel 5,7-disubstituted[1,6]naphthyridines as potent inhibitors of Spleen Tyrosine Kinase (SYK) is discussed. The SAR reveals the necessity…”
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The Squarate Ester−Polyquinane Connection. An Analysis of the Capacity of Achiral Divinyl Adducts To Rearrange Spontaneously to Polycyclic Networks Housing Multiple Stereogenic Centers by Paquette, Leo A, Morwick, Tina M

“…The condensation of diisopropyl squarate and related cyclobutene-1,2-diones with 2 equiv of the same alkenyl anion or 1 equiv each of two different alkenyl…”
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Combined Addition of Alkenyl and Allenic Anions to Squarate Esters. Direct Competition between Six-Ring and Eight-Ring Electrocyclization of 1,2,4,6,8-Cumulenic Pentaenes by Morwick, Tina M, Paquette, Leo A

“…The sequential addition of 1 equiv each of a lithioallene and an alkenyllithium to diisopropyl squarate has been studied. The product compositions resulting…”
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The Squarate Ester-1,3,5,7-Octatetraene-Polyquinane Cascade: Reaction Efficiency Is Intimately Linked to the Locus of Substitution within the Vinyl Anion by Paquette, Leo A, Morwick, Tina

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Mapping the Chemical Reactivity of Polyquinanes Produced by 2-fold Addition of Vinyl Anions to Squarate Esters. A Bicyclic Case Study by Morwick, Tina M, Paquette, Leo A

“…A highly oxygenated diquinane representative of the product class obtained from the condensation of squarate esters with a pair of vinyl anions has been…”
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High-Throughput Ester Hydrolysis with Catch-and-Release Isolation of Carboxylic Acids by Morwick, Tina M

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Tandem Alkylation/Ester Hydrolysis Using Polymer-Supported Hydroxide for Catch and Release Isolation of a Series of Benzoimidazolonecarboxylic Acids by Welzel, Morgan, Morwick, Tina M

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Hit to Lead Account of the Discovery of a New Class of Inhibitors of Pim Kinases and Crystallographic Studies Revealing an Unusual Kinase Binding Mode by Qian, Kevin, Wang, Lian, Cywin, Charles L, Farmer, Bennett T, Hickey, Eugene, Homon, Carol, Jakes, Scott, Kashem, Mohammed A, Lee, George, Leonard, Scott, Li, Jun, Magboo, Ronald, Mao, Wang, Pack, Edward, Peng, Charlene, Prokopowicz, Anthony, Welzel, Morgan, Wolak, John, Morwick, Tina

“…A series of inhibitors of Pim-2 kinase identified by high-throughput screening is described. Details of the hit validation and lead generation process and…”
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Addition of 2,3-dihydro-5-furanyllithium to diisopropyl squarate as a means for the rapid generation of structurally complex oxygen-containing tetraquinane networks by Paquette, Leo A., Morwick, Tina M., Negri, Joanna T., Rogers, Robin D.

“…The ability of 2,3-dihydro-5-furanyllithium ( 11) to trigger a reaction cascade when added to diisopropyl squarate ( 6) has been examined. Of particular…”
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Evolution of the Thienopyridine Class of Inhibitors of IκB Kinase-β:  Part I:  Hit-to-Lead Strategies by Morwick, Tina, Berry, Angela, Brickwood, Janice, Cardozo, Mario, Catron, Katrina, DeTuri, Molly, Emeigh, Jonathan, Homon, Carol, Hrapchak, Matt, Jacober, Stephen, Jakes, Scott, Kaplita, Paul, Kelly, Terence A, Ksiazek, John, Liuzzi, Michel, Magolda, Ronald, Mao, Can, Marshall, Daniel, McNeil, Daniel, Prokopowicz, Anthony, Sarko, Christopher, Scouten, Erika, Sledziona, Cynthia, Sun, Sanxing, Watrous, Jane, Wu, Jiang Ping, Cywin, Charles L

“…High-throughput screening is routinely employed as a method for the identification of novel hit structures. Large numbers of active compounds are typically…”
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The discovery of carboline analogs as potent MAPKAP-K2 inhibitors by Wu, Jiang-Ping, Wang, Ji, Abeywardane, Asitha, Andersen, Denise, Emmanuel, Michel, Gautschi, Elda, Goldberg, Daniel R., Kashem, Mohammed A., Lukas, Susan, Mao, Wang, Martin, Leslie, Morwick, Tina, Moss, Neil, Pargellis, Christopher, Patel, Usha R., Patnaude, Lori, Peet, Gregory W., Skow, Donna, Snow, Roger J., Ward, Yancey, Werneburg, Brian, White, Andre

“…The discovery of a series of potent, carboline-based MK2 inhibitors is described. These compounds inhibit MK2 with IC50s as low as 10nM, as measured in a…”
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Direct elaboration of complex polyquinanes through twofold addition of vinyl anions to squarate esters by Negri, Joanna, Morwick, Tina, Doyon, Julien, Wilson, Peter D, Hickey, Eugene R, Paquette, Leo A

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