Search Results - "Morvan, François"

Phthalimide and 3‐Formylindole Derivatives for Oligonucleotide Conjugation by Amide or Oxime Ligation by Graidia, Nessrine, Meyer, Albert, Smietana, Michael, Morvan, François

“…A phthalimide or 3‐formylindole functionality was incorporated into a tris(hydroxymethyl)ethane (THME) scaffold, and the resulting compounds were subsequently…”
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Stabilization of DNA Duplexes and Hairpins by Charge-Transfer Interactions Using DAN:NDI Pairs by Pérez de Carvasal, Kévan, Nicollet, Laura, Smietana, Michael, Morvan, François

“…Electron-rich 1,5-dialkoxynaphthalene (DAN) and electron-deficient 1,8,4,5-naphthalenetetracarboxylic diimide (NDI) are known to interact through the formation…”
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Fluorescent Thrombin Binding Aptamer-Tagged Nanoparticles for an Efficient and Reversible Control of Thrombin Activity by Riccardi, Claudia, Russo Krauss, Irene, Musumeci, Domenica, Morvan, François, Meyer, Albert, Vasseur, Jean-Jacques, Paduano, Luigi, Montesarchio, Daniela

“…Progress in understanding and treatment of thrombotic diseases requires new effective methods for the easy, rapid, and reversible control of coagulation…”
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Glycoclusters on oligonucleotide and PNA scaffolds: synthesis and applications by Spinelli, Nicolas, Defrancq, Eric, Morvan, François

“…Conjugation of oligonucleotides (ONs) to a variety of reporter groups has been the subject of intensive research during the last decade. Conjugation is indeed…”
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Supramolecular Recognition of Phosphodiester-Based Donor and Acceptor Oligomers Forming Gels in Water by de Carvasal, Kévan Pérez, Vergoten, Gérard, Vasseur, Jean-Jacques, Smietana, Michael, Morvan, François

“…Inspired by automated DNA synthesis, electron-rich dialkoxynaphthalene (DAN) donor and electron-deficient naphthalene-tetracarboxylic diimide (NDI) acceptor…”
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Predicting Chemotherapy Toxicity and Death in Older Adults with Colon Cancer: Results of MOST Study by Retornaz, Frédérique, Guillem, Olivier, Rousseau, Frédérique, Morvan, Francois, Rinaldi, Yves, Nahon, Sophie, Castagna, Chantal, Boulahssass, Rabia, Grino, Michel, Gholam, Dany

“…Purpose Older patients with colon cancer (CC) are vulnerable to chemotherapy toxicity and death. Establishing simple scores specific for patients with CC to…”
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Synthesis of Mannose and Galactose Oligonucleotide Conjugates by Bi-click chemistry by Pourceau, Gwladys, Meyer, Albert, Vasseur, Jean-Jacques, Morvan, François

“…Glyco oligonucleotide conjugates, each exhibiting two mannose and two galactose residues, were efficiently synthesized by two successive 1,3-dipolar…”
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Oligonucleotide Conjugation by Tyrosine‐Click Reaction by Meyer, Albert, Baraguey, Carine, Vasseur, Jean‐Jacques, Morvan, François

“…N,O‐Diacetyl tyrosine and 3‐(4‐hydroxy‐phenyl)‐propanoic acid were converted into phosphoramidite derivatives and introduced to the 5′‐end of oligonucleotides…”
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Solid Supports for the Synthesis of 3′-Aminooxy Deoxy- or Ribo-oligonucleotides and Their 3′-Conjugation by Oxime Ligation by Noël, Mathieu, Clément-Blanc, Céline, Meyer, Albert, Vasseur, Jean-Jacques, Morvan, François

“…Mono- and triethylene glycol aminooxy derivatives were reacted with levulinic acid, protected with dimethoxytrityl, and immobilized on solid support. The…”
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Design, Synthesis and Characterization of Cyclic NU172 Analogues: A Biophysical and Biological Insight by Riccardi, Claudia, Meyer, Albert, Vasseur, Jean-Jacques, Cavasso, Domenico, Russo Krauss, Irene, Paduano, Luigi, Morvan, François, Montesarchio, Daniela

“…NU172-a 26-mer oligonucleotide able to bind exosite I of human thrombin and inhibit its activity-was the first aptamer to reach Phase II clinical studies as an…”
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Fine-tuning the properties of the thrombin binding aptamer through cyclization: Effect of the 5′-3′ connecting linker on the aptamer stability and anticoagulant activity by Riccardi, Claudia, Meyer, Albert, Vasseur, Jean-Jacques, Russo Krauss, Irene, Paduano, Luigi, Morvan, François, Montesarchio, Daniela

“…[Display omitted] •4 novel cyclic TBAs were synthesized by connecting the 5′- and 3′-ends of the sequence.•Their physico-chemical properties, serum resistance…”
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Charge-Transfer Interactions Stabilize G-Quadruplex-Forming Thrombin Binding Aptamers and Can Improve Their Anticoagulant Activity by Pérez de Carvasal, Kévan, Riccardi, Claudia, Russo Krauss, Irene, Cavasso, Domenico, Vasseur, Jean-Jacques, Smietana, Michael, Morvan, François, Montesarchio, Daniela

“…In the search for optimized thrombin binding aptamers (TBAs), we herein describe the synthesis of a library of TBA analogues obtained by end-functionalization…”
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Azide Solid Support for 3′-Conjugation of Oligonucleotides and Their Circularization by Click Chemistry by Pourceau, Gwladys, Meyer, Albert, Vasseur, Jean-Jacques, Morvan, François

“…A solid support bearing an azido linker was used to synthesize a 3′-azido-alkyl-oligonucleotide by phosphoramidite chemistry. The resulting oligonucleotide was…”
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Structure Binding Relationship of Galactosylated Glycoclusters toward Pseudomonas aeruginosa Lectin LecA Using a DNA-Based Carbohydrate Microarray by Gerland, Béatrice, Goudot, Alice, Ligeour, Caroline, Pourceau, Gwladys, Meyer, Albert, Vidal, Sébastien, Gehin, Thomas, Vidal, Olivier, Souteyrand, Eliane, Vasseur, Jean-Jacques, Chevolot, Yann, Morvan, François

“…Pseudomonas aeruginosa (PA) is a major public health issue due to its impact on nosocomial infections as well as its impact on cystic fibrosis patient…”
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A terminal functionalization strategy reveals unusual binding abilities of anti-thrombin anticoagulant aptamers by Troisi, Romualdo, Riccardi, Claudia, Pérez de Carvasal, Kévan, Smietana, Michael, Morvan, François, Del Vecchio, Pompea, Montesarchio, Daniela, Sica, Filomena

“…Despite their unquestionable properties, oligonucleotide aptamers display some drawbacks that continue to hinder their applications. Several strategies have…”
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Stability Is Not Everything: The Case of the Cyclisation of a Thrombin‐Binding Aptamer by Riccardi, Claudia, Meyer, Albert, Vasseur, Jean‐Jacques, Russo Krauss, Irene, Paduano, Luigi, Oliva, Rosario, Petraccone, Luigi, Morvan, François, Montesarchio, Daniela

“…With the aim of developing a new approach to obtain improved aptamers, a cyclic thrombin‐binding aptamer (TBA) analogue (cycTBA) has been prepared by…”
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Probing naphthalene diimide and 3-hydroxypropylphosphate as end-conjugating moieties for improved thrombin binding aptamers: Structural and biological effects by Riccardi, Claudia, Pérez de Carvasal, Kévan, Platella, Chiara, Meyer, Albert, Smietana, Michael, Morvan, François, Montesarchio, Daniela

“…[Display omitted] •Modified TBAs were synthesized by linking naphthalendiimides (N) and 3-hydroxypropylphosphate (p) at the ends.•Their physico-chemical…”
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Fluorescence Enhancement upon G‑Quadruplex Folding: Synthesis, Structure, and Biophysical Characterization of a Dansyl/Cyclodextrin-Tagged Thrombin Binding Aptamer by De Tito, Stefano, Morvan, François, Meyer, Albert, Vasseur, Jean-Jacques, Cummaro, Annunziata, Petraccone, Luigi, Pagano, Bruno, Novellino, Ettore, Randazzo, Antonio, Giancola, Concetta, Montesarchio, Daniela

“…A novel fluorescent thrombin binding aptamer (TBA), conjugated with the environmentally sensitive dansyl probe at the 3′-end and a β-cyclodextrin residue at…”
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Improved Performance of DNA Microarray Multiplex Hybridization Using Probes Anchored at Several Points by Thiol–Ene or Thiol–Yne Coupling Chemistry by Bañuls, Maria-Jose, Jiménez-Meneses, Pilar, Meyer, Albert, Vasseur, Jean-Jacques, Morvan, François, Escorihuela, Jorge, Puchades, Rosa, Maquieira, Ángel

“…Nucleic acid microarray-based assay technology has shown lacks in reproducibility, reliability, and analytical sensitivity. Here, a new strategy of probe…”
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Thermolytic Reagents to Synthesize 5′‐ or 3′‐Mono(thio)phosphate Oligodeoxynucleotides or 3′‐modified oligodeoxynucleotides by Madaoui, Mimouna, Meyer, Albert, Vasseur, Jean‐Jacques, Morvan, François

“…Methylthioethanol and 2,2′‐thiodiethanol were derivatized into cyanoethyl‐phosphoramidites and solid support and were used to synthesize 5′‐, 3′‐monophosphate…”
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