Search Results - "Mortz, Ejvind"

Monitoring process-related impurities in biologics–host cell protein analysis by Pilely, Katrine, Johansen, Martin Rask, Lund, Rikke Raaen, Kofoed, Thomas, Jørgensen, Thomas Kjærsgaard, Skriver, Lars, Mørtz, Ejvind

“…During biologics development, manufacturers must demonstrate clearance of host cell impurities and contaminants to ensure drug purity, manufacturing process…”
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Delayed bactericidal response of Mycobacterium tuberculosis to bedaquiline involves remodelling of bacterial metabolism by Koul, Anil, Vranckx, Luc, Dhar, Neeraj, Göhlmann, Hinrich W.H., Özdemir, Emre, Neefs, Jean-Marc, Schulz, Melanie, Lu, Ping, Mørtz, Ejvind, McKinney, John D., Andries, Koen, Bald, Dirk

“…Bedaquiline (BDQ), an ATP synthase inhibitor, is the first drug to be approved for treatment of multidrug-resistant tuberculosis in decades. Though BDQ has…”
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Discrimination of Isoleucine and Leucine by Dimethylation-Assisted MS3 by Maibom-Thomsen, Sheila, Heissel, Søren, Mørtz, Ejvind, Højrup, Peter, Bunkenborg, Jakob

“…Protein sequencing by mass spectrometry has transformed the field of biopharmaceutical analysis, but a missing part in the analytical toolkit is the ability to…”
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Evaluation of spectral libraries and sample preparation for DIA-LC-MS analysis of host cell proteins: A case study of a bacterially expressed recombinant biopharmaceutical protein by Heissel, Søren, Bunkenborg, Jakob, Kristiansen, Max Per, Holmbjerg, Anne Fich, Grimstrup, Marie, Mørtz, Ejvind, Kofoed, Thomas, Højrup, Peter

“…Recombinantly expressed biopharmaceutical proteins often undergo a series of purification steps with the aim of removing contaminating material. Depending on…”
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Improved silver staining protocols for high sensitivity protein identification using matrix-assisted laser desorption/ionization-time of flight analysis by Mortz, Ejvind, Krogh, Thomas N., Vorum, Henrik, Görg, Angelika

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Subcellular fractionation of TGF-β1-stimulated lung epithelial cells: A novel proteomic approach for identifying signaling intermediates by Milosevic, Jadranka, Bulau, Patrick, Mortz, Ejvind, Eickelberg, Oliver

“…Members of the transforming growth factor (TGF)-β superfamily are key regulators of lung development and homeostasis, in particular by controlling…”
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The Corky Root Rot Pathogen Pyrenochaeta lycopersici Secretes a Proteinaceous Inducer of Cell Death Affecting Host Plants Differentially by CLERGEOT, Pierre-Henri, SCHULER, Herwig, MØRTZ, Ejvind, BRUS, Maja, VINTILA, Simina, EKENGREN, Sophia

“…Pathogenic isolates of Pyrenochaeta lycopersici, the causal agent of corky root rot of tomato, secrete cell death in tomato 1 (CDiT1), a homodimeric protein of…”
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A novel approach to evaluate ELISA antibody coverage of host cell proteins—combining ELISA‐based immunocapture and mass spectrometry by Pilely, Katrine, Nielsen, Solveig B., Draborg, Anette, Henriksen, Maiken L., Hansen, Søren W. K., Skriver, Lars, Mørtz, Ejvind, Lund, Rikke R.

“…Monitoring host cell proteins (HCPs) is one of the most important analytical requirements in production of recombinant biopharmaceuticals to ensure product…”
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Sequence tag identification of intact proteins by matching tandem mass spectral data against sequence data bases by Mortz, E, O'Connor, P.B, Roepstorff, P, Kelleher, N.L, Wood, T.D, McLafferty, F.W, Mann, M

“…Molecular and fragment ion data of intact 8- to 43-kDa proteins from electrospray Fourier-transform tandem mass spectrometry are matched against the…”
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The quest for ingested peanut protein in human serum by Pahlow Mose, Anja, Mortz, Ejvind, Stahl Skov, Per, Mortz, Charlotte Gotthard, Eller, Esben, Sprogøe, Ulrik, Barington, Torben, Bindslev‐Jensen, Carsten

“…Background There is mounting evidence that systemic uptake of food allergens is key to triggering anaphylaxis. However, direct proof for this theory is still…”
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Identification of proteins in polyacrylamide gels by mass spectrometric peptide mapping combined with database search by Mørtz, E, Vorm, O, Mann, M, Roepstorff, P

“…Mass spectrometric peptide mapping of proteins separated by one-dimensional sodium dodecyl sulphate polyacrylamide gel electrophoresis has been investigated…”
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Isolation and characterization of putative trefoil peptide receptors by Thim, Lars, Mørtz, Ejvind

“…Mammalian trefoil factors (TFFs) constitute a group of three peptides (TFF1, TFF2 and TFF3) widely distributed in the gastrointestinal tract. Although a…”
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Subproteomics: Identification of plasma membrane proteins from the yeast Saccharomyces cerevisiae by Navarre, Catherine, Degand, Hervé, Bennett, Keiryn L., Crawford, Janne S., Mørtz, Ejvind, Boutry, Marc

“…As a consequence of their poor solubility during isoelectric focusing, integral membrane proteins are generally absent from two‐dimensional gel proteome maps…”
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Glycosylation analysis of gel-separated proteins by Küster, Bernhard, Krogh, Thomas N., Mørtz, Ejvind, Harvey, David J.

“…Beyond the identification of proteins involved in a particular physiological situation, many aspects of proteomics require more detailed characterization of…”
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Recommendations on: internal standard criteria, stability, incurred sample reanalysis and recent 483s by the Global CRO Council for Bioanalysis by Lowes, Steve, Jersey, Jim, Shoup, Ronald, Garofolo, Fabio, Savoie, Natasha, Mortz, Ejvind, Needham, Shane, Caturla, Maria Cruz, Steffen, Ray, Sheldon, Curtis, Hayes, Roger, Samuels, Tim, Di Donato, Lorella, Kamerud, John, Michael, Steve, Lin, Zhongping John, Hillier, Jim, Moussallie, Marc, de Souza Teixeira, Leonardo, Rocci, Mario, Buonarati, Mike, Truog, James, Hussain, Saleh, Lundberg, Richard, Breau, Alan, Zhang, Tianyi, Jonker, Jianine, Berger, Neil, Gagnon-Carignan, Sofi, Nehls, Corey, Nicholson, Robert, Hilhorst, Martijn, Karnik, Shane, de Boer, Theo, Houghton, Richard, Smith, Kirk, Cojocaru, Laura, Allen, Mike, Harter, Tammy, Fatmi, Saadya, Sayyarpour, Farhad, Vija, Jenifer, Malone, Michele, Heller, Dennis

“…"The Global CRO Council (GCC) for Bioanalysis was formed in an effort to bring together many CRO leaders to openly discuss bioanalysis and the regulatory…”
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Subcellular fractionation of TGF-beta1-stimulated lung epithelial cells: a novel proteomic approach for identifying signaling intermediates by Milosevic, Jadranka, Bulau, Patrick, Mortz, Ejvind, Eickelberg, Oliver

“…Members of the transforming growth factor (TGF)-beta superfamily are key regulators of lung development and homeostasis, in particular by controlling…”
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Improved silver staining protocols for high sensitivity protein identification using matrix‐assisted laser desorption/ionization‐time of flight analysis by Mortz, Ejvind, Krogh, Thomas N., Vorum, Henrik, Görg, Angelika

“…In proteomics it is essential to be able to detect proteins separated by gel electrophoresis at high sensitivity. Silver staining is currently the most popular…”
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The corky root rot pathogen Pyrenochaeta lycopersici secretes a proteinaceous inducer of cell death affecting host plants differentially by Clergeot, Pierre-Henri, Schuler, Herwig, Mørtz, Ejvind, Brus, Maja, Vintila, Simina, Ekengren, Sophia

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A Urokinase Receptor-associated Protein with Specific Collagen Binding Properties by Behrendt, Niels, Jensen, Ole N., Engelholm, Lars H., Mørtz, Ejvind, Mann, Matthias, Danø, Keld

“…The plasminogen activation cascade system, directed by urokinase and the urokinase receptor, plays a key role in extracellular proteolysis during tissue…”
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Isolation and characterization of putative trefoil peptide receptors by Thim, Lars, Mørtz, Ejvind

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