Search Results - "Morton, Stuart"

Platelet‐derived growth factor‐D and Rho GTPases regulate recruitment of cancer‐associated fibroblasts in cholangiocarcinoma by Cadamuro, Massimiliano, Nardo, Giorgia, Indraccolo, Stefano, Dall'Olmo, Luigi, Sambado, Luisa, Moserle, Lidia, Franceschet, Irene, Colledan, Michele, Massani, Marco, Stecca, Tommaso, Bassi, Nicolò, Morton, Stuart, Spirli, Carlo, Fiorotto, Romina, Fabris, Luca, Strazzabosco, Mario

“…Cholangiocarcinoma (CCA) is characterized by an abundant stromal reaction. Cancer‐associated fibroblasts (CAFs) are pivotal in tumor growth and invasiveness…”
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Protein kinase A-dependent pSer(675) -β-catenin, a novel signaling defect in a mouse model of congenital hepatic fibrosis by Spirli, Carlo, Locatelli, Luigi, Morell, Carola M, Fiorotto, Romina, Morton, Stuart D, Cadamuro, Massimiliano, Fabris, Luca, Strazzabosco, Mario

“…Genetically determined loss of fibrocystin function causes congenital hepatic fibrosis (CHF), Caroli disease (CD), and autosomal recessive polycystic kidney…”
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QSAR Model of Unbound Brain-to-Plasma Partition Coefficient, Kp,uu,brain: Incorporating P-glycoprotein Efflux as a Variable by Dolgikh, Elena, Watson, Ian A, Desai, Prashant V, Sawada, Geri A, Morton, Stuart, Jones, Timothy M, Raub, Thomas J

“…We report development and prospective validation of a QSAR model of the unbound brain-to-plasma partition coefficient, Kp,uu,brain, based on the in-house data…”
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Considerations for Analyzing and Interpreting Data from Biometric Monitoring Technologies in Clinical Trials by Ratitch, Bohdana, Rodriguez-Chavez, Isaac R., Dabral, Abhishek, Fontanari, Adriano, Vega, Julio, Onorati, Francesco, Vandendriessche, Benjamin, Morton, Stuart, Damestani, Yasaman

“…Background: The proliferation and increasing maturity of biometric monitoring technologies allow clinical investigators to measure the health status of trial…”
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Isolation and characterization of biliary epithelial and stromal cells from resected human cholangiocarcinoma: A novel in vitro model to study tumor-stroma interactions by MASSANI, MARCO, STECCA, TOMMASO, FABRIS, LUCA, CARATOZZOLO, EZIO, RUFFOLO, CESARE, FURLANETTO, ALBERTO, MORTON, STUART, CADAMURO, MASSIMILIANO, STRAZZABOSCO, MARIO, BASSI, NICOLÒ

“…Cholangiocarcinoma (CCA) is a devastating malignancy arising from the bile ducts. Cancer-associated fibroblasts (CAFs) are key players in CCA invasiveness and…”
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Leukemia inhibitory factor protects cholangiocarcinoma cells from drug-induced apoptosis via a PI3K/AKT-dependent Mcl-1 activation by Morton, Stuart Duncan, Cadamuro, Massimiliano, Brivio, Simone, Vismara, Marta, Stecca, Tommaso, Massani, Marco, Bassi, Nicolò, Furlanetto, Alberto, Joplin, Ruth Elizabeth, Floreani, Annarosa, Fabris, Luca, Strazzabosco, Mario

“…Cholangiocarcinoma is an aggressive, strongly chemoresistant liver malignancy. Leukemia inhibitory factor (LIF), an IL-6 family cytokine, promotes progression…”
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In silico approaches to predicting cancer potency for risk assessment of genotoxic impurities in drug substances by Bercu, Joel P., Morton, Stuart M., Deahl, J. Thom, Gombar, Vijay K., Callis, Courtney M., van Lier, Robert B.L.

“…The current risk assessment approach for addressing the safety of very small concentrations of genotoxic impurities (GTIs) in drug substances is the threshold…”
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Efficiency Gains in Tracer Identification for Nuclear Imaging: Can In Vivo LC-MS/MS Evaluation of Small Molecules Screen for Successful PET Tracers? by Joshi, Elizabeth M, Need, Anne, Schaus, John, Chen, Zhaogen, Benesh, Dana, Mitch, Charles, Morton, Stuart, Raub, Thomas J, Phebus, Lee, Barth, Vanessa

“…Positron emission tomography (PET) imaging has become a useful noninvasive technique to explore molecular biology within living systems; however, the utility…”
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How well do lipophilicity parameters, MEEKC microemulsion capacity factor, and plasma protein binding predict CNS tissue binding? by Zamek-Gliszczynski, Maciej J, Sprague, Karen E, Espada, Alfonso, Raub, Thomas J, Morton, Stuart M, Manro, Jason R, Molina-Martin, Manuel

“…Brain fraction unbound (Fu) is critical to understanding the pharmacokinetics/dynamics of central nervous system (CNS) drugs, thus several surrogate predictors…”
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Assessing the Impact of Interactive Educational Videos and Screencasts Within Pre-clinical Microanatomy and Medical Physiology Teaching by Robson, Alistair, Scantling-Birch, Yarrow, Morton, Stuart, Anbu, Deepika, Border, Scott

“…Modern medical curricula adopt the use self-directed learning approaches, which frequently include the use of technology enhanced learning resources. Often,…”
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824 Biologic Use in Pediatric Patients Newly Diagnosed With Ulcerative Colitis in the United States, 2010-2013 and 2014-2016 by D'Haens, Geert R., Naegeli, April, Mahoui, Malika, Morton, Stuart, Dong, Yan, Hunter, Theresa

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826 Biologic Use in Pediatric Patients Newly Diagnosed With Crohn’s Disease in the United States, 2010-2013 and 2014-2016 by D'Haens, Geert R., Naegeli, April, Mahoui, Malika, Morton, Stuart, Dong, Yan, Hunter, Theresa

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Protein kinase a‐dependent pSer675‐β‐catenin, a novel signaling defect in a mouse model of congenital hepatic fibrosis by Spirli, Carlo, Locatelli, Luigi, Morell, Carola M., Fiorotto, Romina, Morton, Stuart D., Cadamuro, Massimiliano, Fabris, Luca, Strazzabosco, Mario

“…Genetically determined loss of fibrocystin function causes congenital hepatic fibrosis (CHF), Caroli disease (CD), and autosomal recessive polycystic kidney…”
Get full text

QSAR Model of Unbound Brain-to-Plasma Partition Coefficient, K^sub p,uu,brain^: Incorporating P-glycoprotein Efflux as a Variable by Dolgikh, Elena, Watson, Ian A, Desai, Prashant V, Sawada, Geri A, Morton, Stuart, Jones, Timothy M, Raub, Thomas J

“…We report development and prospective validation of a QSAR model of the unbound brain-to-plasma partition coefficient, K^sub p,uu,brain^, based on the in-house…”
Get full text

Using Similarity Metrics on Real World Data and Patient Treatment Pathways to Recommend the Next Treatment by Haas, Kyle, Morton, Stuart, Gupta, Simone, Mahoui, Malika

“…Non-small-cell lung cancer (NSCLC) is one of the most prevalent types of lung cancer and continues to have an ominous five year survival rate. Considerable…”
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QSAR Model of Unbound Brain-to-Plasma Partition Coefficient, K p,uu,brain: Incorporating P‑glycoprotein Efflux as a Variable by Dolgikh, Elena, Watson, Ian A, Desai, Prashant V, Sawada, Geri A, Morton, Stuart, Jones, Timothy M, Raub, Thomas J

“…We report development and prospective validation of a QSAR model of the unbound brain-to-plasma partition coefficient, K p,uu,brain, based on the in-house data…”
Get full text

Protein kinase a-dependent pSer675-[beta]-catenin, a novel signaling defect in a mouse model of congenital hepatic fibrosis by Spirli, Carlo, Locatelli, Luigi, Morell, Carola M, Fiorotto, Romina, Morton, Stuart D, Cadamuro, Massimiliano, Fabris, Luca, Strazzabosco, Mario

“…Genetically determined loss of fibrocystin function causes congenital hepatic fibrosis (CHF), Caroli disease (CD), and autosomal recessive polycystic kidney…”
Get full text

PKA dependent p-Ser-675β-catenin, a novel signaling defect in a mouse model of Congenital Hepatic Fibrosis by Spirli, Carlo, Locatelli, Luigi, Morell, Carola M., Fiorotto, Romina, Morton, Stuart D., Cadamuro, Massimiliano, Fabris, Luca, Strazzabosco, Mario

“…Genetically-determined loss of fibrocystin function causes Congenital Hepatic Fibrosis (CHF), Caroli Disease (CD) and Autosomal Recessive Polycystic Kidney…”
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Unveiling the role of tumor reactive stroma in cholangiocarcinoma: an opportunity for new therapeutic strategies by Cadamuro, Massimiliano, Morton, Stuart Duncan, Strazzabosco, Mario, Fabris, Luca

“…Cholangiocarcinoma (CCA) is a very aggressive neoplasm, whose incidence has steadily increased in the last decade. Despite its growing epidemiological impact,…”
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Haemodynamic improvement in a child with meningococcal sepsis following methylprednisolone: restoration of beta-adrenergic receptor responsiveness? by O'BRIEN, KAY, STUART MORTON, NEIL

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