Search Results - "Morton, P"

Substrate Rigidity Controls Activation and Durotaxis in Pancreatic Stellate Cells by Lachowski, Dariusz, Cortes, Ernesto, Pink, Daniel, Chronopoulos, Antonios, Karim, Saadia A., P. Morton, Jennifer, del Río Hernández, Armando E.

“…Pancreatic Ductal Adenocarcinoma (PDAC) is an aggressive malignancy characterised by the presence of extensive desmoplasia, thought to be responsible for the…”
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The senescence-associated secretory phenotype induces cellular plasticity and tissue regeneration by Ritschka, Birgit, Storer, Mekayla, Mas, Alba, Heinzmann, Florian, Ortells, Mari Carmen, Morton, Jennifer P, Sansom, Owen J, Zender, Lars, Keyes, William M

“…Senescence is a form of cell cycle arrest induced by stress such as DNA damage and oncogenes. However, while arrested, senescent cells secrete a variety of…”
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Reshaping the Tumor Stroma for Treatment of Pancreatic Cancer by Vennin, Claire, Murphy, Kendelle J., Morton, Jennifer P., Cox, Thomas R., Pajic, Marina, Timpson, Paul

“…Pancreatic cancer is accompanied by a fibrotic reaction that alters interactions between tumor cells and the stroma to promote tumor progression. Consequently,…”
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Nutrient content and stoichiometry of pelagic Sargassum reflects increasing nitrogen availability in the Atlantic Basin by Lapointe, B. E., Brewton, R. A., Herren, L. W., Wang, M., Hu, C., McGillicuddy, D. J., Lindell, S., Hernandez, F. J., Morton, P. L.

“…The pelagic brown macroalgae Sargassum spp. have grown for centuries in oligotrophic waters of the North Atlantic Ocean supported by natural nutrient sources,…”
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Fuel for the Work Required: A Theoretical Framework for Carbohydrate Periodization and the Glycogen Threshold Hypothesis by Impey, Samuel G., Hearris, Mark A., Hammond, Kelly M., Bartlett, Jonathan D., Louis, Julien, Close, Graeme L., Morton, James P.

“…Deliberately training with reduced carbohydrate (CHO) availability to enhance endurance-training-induced metabolic adaptations of skeletal muscle (i.e. the…”
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Macrophage-Released Pyrimidines Inhibit Gemcitabine Therapy in Pancreatic Cancer by Halbrook, Christopher J., Pontious, Corbin, Kovalenko, Ilya, Lapienyte, Laura, Dreyer, Stephan, Lee, Ho-Joon, Thurston, Galloway, Zhang, Yaqing, Lazarus, Jenny, Sajjakulnukit, Peter, Hong, Hanna S., Kremer, Daniel M., Nelson, Barbara S., Kemp, Samantha, Zhang, Li, Chang, David, Biankin, Andrew, Shi, Jiaqi, Frankel, Timothy L., Crawford, Howard C., Morton, Jennifer P., Pasca di Magliano, Marina, Lyssiotis, Costas A.

“…Pancreatic ductal adenocarcinoma (PDA) is characterized by abundant infiltration of tumor-associated macrophages (TAMs). TAMs have been reported to drive…”
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Translating complexity and heterogeneity of pancreatic tumor: 3D in vitro to in vivo models by Heinrich, Marcel A., Mostafa, Ahmed M.R.H., Morton, Jennifer P., Hawinkels, Lukas J.A.C., Prakash, Jai

“…[Display omitted] Pancreatic ductal adenocarcinoma (PDAC) is an extremely aggressive type of cancer with an overall survival rate of less than 7–8%,…”
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Somatostatin Interneurons Facilitate Hippocampal-Prefrontal Synchrony and Prefrontal Spatial Encoding by Abbas, Atheir I., Sundiang, Marina J.M., Henoch, Britt, Morton, Mitchell P., Bolkan, Scott S., Park, Alan J., Harris, Alexander Z., Kellendonk, Christoph, Gordon, Joshua A.

“…Decreased hippocampal-prefrontal synchrony may mediate cognitive deficits in schizophrenia, but it remains unclear which cells orchestrate this…”
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The preclinical gap in pancreatic cancer and radiotherapy by Tesson, Mathias, Morton, Jennifer P

“…Pancreatic ductal adenocarcinoma is an aggressive malignancy with limited treatment options. Chemotherapy offers little benefit and, although there is some…”
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A complex secretory program orchestrated by the inflammasome controls paracrine senescence by Acosta, Juan Carlos, Banito, Ana, Wuestefeld, Torsten, Georgilis, Athena, Janich, Peggy, Morton, Jennifer P., Athineos, Dimitris, Kang, Tae-Won, Lasitschka, Felix, Andrulis, Mindaugas, Pascual, Gloria, Morris, Kelly J., Khan, Sadaf, Jin, Hong, Dharmalingam, Gopuraja, Snijders, Ambrosius P., Carroll, Thomas, Capper, David, Pritchard, Catrin, Inman, Gareth J., Longerich, Thomas, Sansom, Owen J., Benitah, Salvador Aznar, Zender, Lars, Gil, Jesús

“…Oncogene-induced senescence (OIS) is crucial for tumour suppression. Senescent cells implement a complex pro-inflammatory response termed the…”
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CAF Subpopulations: A New Reservoir of Stromal Targets in Pancreatic Cancer by Pereira, Brooke A, Vennin, Claire, Papanicolaou, Michael, Chambers, Cecilia R, Herrmann, David, Morton, Jennifer P, Cox, Thomas R, Timpson, Paul

“…Cancer-associated fibroblasts (CAFs) are one of the most significant components in the tumour microenvironment (TME), where they can perform several…”
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A Novel Method for Chronic Social Defeat Stress in Female Mice by Harris, Alexander Z, Atsak, Piray, Bretton, Zachary H, Holt, Emma S, Alam, Raisa, Morton, Mitchell P, Abbas, Atheir I, Leonardo, E David, Bolkan, Scott S, Hen, René, Gordon, Joshua A

“…Historically, preclinical stress studies have often omitted female subjects, despite evidence that women have higher rates of anxiety and depression. In…”
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Human Skeletal Muscle Possesses an Epigenetic Memory of Hypertrophy by Seaborne, Robert A., Strauss, Juliette, Cocks, Matthew, Shepherd, Sam, O’Brien, Thomas D., van Someren, Ken A., Bell, Phillip G., Murgatroyd, Christopher, Morton, James P., Stewart, Claire E., Sharples, Adam P.

“…It is unknown if adult human skeletal muscle has an epigenetic memory of earlier encounters with growth. We report, for the first time in humans, genome-wide…”
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Quantification of training load distribution in mixed martial arts athletes: A lack of periodisation and load management by Kirk, Christopher, Langan-Evans, Carl, Clark, David R, Morton, James P

“…The aim of this study was to quantify typical training load and periodisation practices of MMA athletes. MMA competitors (n = 14; age = 22.4 ± 4.4 years; body…”
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A Stromal Lysolipid-Autotaxin Signaling Axis Promotes Pancreatic Tumor Progression by Auciello, Francesca R, Bulusu, Vinay, Oon, Chet, Tait-Mulder, Jacqueline, Berry, Mark, Bhattacharyya, Sohinee, Tumanov, Sergey, Allen-Petersen, Brittany L, Link, Jason, Kendsersky, Nicholas D, Vringer, Esmee, Schug, Michelle, Novo, David, Hwang, Rosa F, Evans, Ronald M, Nixon, Colin, Dorrell, Craig, Morton, Jennifer P, Norman, Jim C, Sears, Rosalie C, Kamphorst, Jurre J, Sherman, Mara H

“…Pancreatic ductal adenocarcinoma (PDAC) develops a pronounced stromal response reflecting an aberrant wound-healing process. This stromal reaction features…”
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Matrix stiffness induces epithelial–mesenchymal transition and promotes chemoresistance in pancreatic cancer cells by Rice, A J, Cortes, E, Lachowski, D, Cheung, B C H, Karim, S A, Morton, J P, del Río Hernández, A

“…Increased matrix rigidity associated with the fibrotic reaction is documented to stimulate intracellular signalling pathways that promote cancer cell survival…”
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Hippocampal-Prefrontal Theta Transmission Regulates Avoidance Behavior by Padilla-Coreano, Nancy, Canetta, Sarah, Mikofsky, Rachel M., Alway, Emily, Passecker, Johannes, Myroshnychenko, Maxym V., Garcia-Garcia, Alvaro L., Warren, Richard, Teboul, Eric, Blackman, Dakota R., Morton, Mitchell P., Hupalo, Sofiya, Tye, Kay M., Kellendonk, Christoph, Kupferschmidt, David A., Gordon, Joshua A.

“…Long-range synchronization of neural oscillations correlates with distinct behaviors, yet its causal role remains unproven. In mice, tests of avoidance…”
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Influence of vitamin C and vitamin E on redox signaling: Implications for exercise adaptations by Cobley, James N., McHardy, Helen, Morton, James P., Nikolaidis, Michalis G., Close, Graeme L.

“…The exogenous antioxidants vitamin C (ascorbate) and vitamin E (α-tocopherol) often blunt favorable cell signaling responses to exercise, suggesting that redox…”
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Cancer-Specific Loss of p53 Leads to a Modulation of Myeloid and T Cell Responses by Blagih, Julianna, Zani, Fabio, Chakravarty, Probir, Hennequart, Marc, Pilley, Steven, Hobor, Sebastijan, Hock, Andreas K., Walton, Josephine B., Morton, Jennifer P., Gronroos, Eva, Mason, Susan, Yang, Ming, McNeish, Iain, Swanton, Charles, Blyth, Karen, Vousden, Karen H.

“…Loss of p53 function contributes to the development of many cancers. While cell-autonomous consequences of p53 mutation have been studied extensively, the role…”
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Investment effects of pricing schemes for non-convex markets by Mays, Jacob, Morton, David P., O’Neill, Richard P.

“…•Electricity markets use a variety of approaches to address non-convex costs.•Competing methods affect resource compensation and therefore investment…”
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