Search Results - "Morton, N. M."

Ethnic identity, resettlement stress and depressive affect among Southeast Asian refugees in Canada by Beiser, Morton N.M.N., Hou, Feng

“…Does commitment to an ethnic identity enhance or jeopardize psychological well-being? Using data from a study of Southeast Asian “Boat People”, this study…”
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A Transgenic Model of Visceral Obesity and the Metabolic Syndrome by Masuzaki, Hiroaki, Paterson, Janice, Shinyama, Hiroshi, Morton, Nicholas M., Mullins, John J., Seckl, Jonathan R., Flier, Jeffrey S.

“…The adverse metabolic consequences of obesity are best predicted by the quantity of visceral fat. Excess glucocorticoids produce visceral obesity and diabetes,…”
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Expression of the functional leptin receptor mRNA in pancreatic islets and direct inhibitory action of leptin on insulin secretion by Emilsson, V., Liu, Y. L., Cawthorne, M. A., Morton, N. M., Davenport, M.

“…Expression of the functional leptin receptor mRNA in pancreatic islets and direct inhibitory action of leptin on insulin secretion. V Emilsson , Y L Liu , M A…”
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Urocortin 3 transgenic mice exhibit a metabolically favourable phenotype resisting obesity and hyperglycaemia on a high-fat diet by Jamieson, P. M., Cleasby, M. E., Kuperman, Y., Morton, N. M., Kelly, P. A. T., Brownstein, D. G., Mustard, K. J., Vaughan, J. M., Carter, R. N., Hahn, C. N., Hardie, D. G., Seckl, J. R., Chen, A., Vale, W. W.

“…Aims/hypothesis Urocortins are the endogenous ligands for the corticotropin-releasing factor receptor type 2 (CRFR2), which is implicated in regulating energy…”
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Preadipocyte 11β-Hydroxysteroid Dehydrogenase Type 1 Is a Keto-Reductase and Contributes to Diet-Induced Visceral Obesity in Vivo by De Sousa Peixoto, R. A, Turban, S, Battle, J. H, Chapman, K. E, Seckl, J. R, Morton, N. M

“…Glucocorticoid excess promotes visceral obesity and cardiovascular disease. Similar features are found in the highly prevalent metabolic syndrome in the…”
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Modulation of susceptibility to weight gain and insulin resistance in low birthweight rats by treatment of their mothers with leptin during pregnancy and lactation by STOCKER, C, O'DOWD, J, MORTON, N. M, WARGENT, E, SENNITT, M. V, HISLOP, D, GLUND, S, SECKL, J. R, ARCH, J. R. S, CAWTHORNE, M. A

“…To investigate whether administration of leptin to rats during pregnancy and lactation affects placental 11beta-hydroxysteroid dehydrogenase (11beta-HSD2)…”
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Glucocorticoid receptor haploinsufficiency causes hypertension and attenuates hypothalamic-pituitary-adrenal axis and blood pressure adaptions to high-fat diet by Michailidou, Z, Carter, R.N, Marshall, E, Sutherland, H.G, Brownstein, D.G, Owen, E, Cockett, K, Kelly, V, Ramage, L, Al-Dujaili, E.A.S, Ross, M, Maraki, I, Newton, K, Holmes, M.C, Seckl, J.R, Morton, N.M, Kenyon, C.J, Chapman, K.E

“…Glucocorticoid hormones are critical to respond and adapt to stress. Genetic variations in the glucocorticoid receptor (GR) gene alter…”
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Glucocorticoid metabolism within superficial subcutaneous rather than visceral adipose tissue is associated with features of the metabolic syndrome in South African women by Goedecke, J. H., Wake, D. J., Levitt, N. S., Lambert, E. V., Collins, M. R., Morton, N. M., Andrew, R., Seckl, J. R., Walker, B. R.

“…Summary Objective  Glucocorticoid hyperactivity in adipose tissue, due to up‐regulation of local glucocorticoid reactivation by 11β‐hydroxysteroid…”
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MDR1 deficiency impairs mitochondrial homeostasis and promotes intestinal inflammation by Ho, G-T, Aird, R E, Liu, B, Boyapati, R K, Kennedy, N A, Dorward, D A, Noble, C L, Shimizu, T, Carter, R N, Chew, E T S, Morton, N M, Rossi, A G, Sartor, R B, Iredale, J P, Satsangi, J

“…The multidrug resistance-1 ( MDR1 ) gene encodes an ATP-dependent efflux transporter that is highly expressed in the colon. In mice, loss of MDR1 function…”
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Leptin signalling in pancreatic islets and clonal insulin-secreting cells by Morton, NM, Emilsson, V, de Groot, P, Pallett, AL, Cawthorne, MA

“…Leptin is a cytokine secreted from adipose tissue at a rate commensurate with the size of the body's fat stores. In addition to its anorectic and thermogenic…”
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Metabolic Syndrome without Obesity: Hepatic Overexpression of 11β-Hydroxysteroid Dehydrogenase Type 1 in Transgenic Mice by Paterson, Janice M., Morton, Nicholas M., Fievet, Catherine, Kenyon, Christopher J., Holmes, Megan C., Staels, Bart, Seckl, Jonathan R., Mullins, John J., Evans, Ronald M.

“…In obese humans and rodents there is increased expression of the key glucocorticoid (GC) regenerating enzyme, 11β-hydroxysteroid dehydrogenase type 1…”
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Expression of the functional leptin receptor mRNA in pancreatic islets and direct inhibitory action of leptin on insulin secretion by EMILSSON, V, LIU, Y.-L, CAWTHORNE, M. A, MORTON, N. M, DAVENPORT, M

“…Leptin, encoded for by the mouse ob gene, regulates feeding behavior and energy metabolism. Its receptor (Ob-R) is encoded by the mouse diabetic (db) gene and…”
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Improved Lipid and Lipoprotein Profile, Hepatic Insulin Sensitivity, and Glucose Tolerance in 11β-Hydroxysteroid Dehydrogenase Type 1 Null Mice by Morton, Nicholas M., Holmes, Megan C., Fiévet, Catherine, Staels, Bart, Tailleux, Anne, Mullins, John J., Seckl, Jonathan R.

“…Excess tissue glucocorticoid action may underlie the dyslipidemia, insulin resistance, and impaired glucose tolerance of the metabolic syndrome…”
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Leptin Action in Intestinal Cells by Morton, Nicholas M., Emilsson, Valur, Liu, Yong-Ling, Cawthorne, Michael A.

“…The adipocyte hormone leptin activates signal transducer and activator of transcription 3 (STAT3) in the hypothalamus, mediating increased satiety and…”
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Leptin Inhibits Insulin Secretion and Reduces Insulin mRNA Levels in Rat Isolated Pancreatic Islets by Pallett, Anna L., Morton, Nicholas M., Cawthorne, Michael A., Emilsson, Valur

“…The ob gene product leptin over the concentration range 0.1–100nM demonstrated a U-shaped dose–response inhibition of glucose-stimulated insulin secretion by…”
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Rat Insulinoma-Derived Pancreatic β-cells Express a Functional Leptin Receptor That Mediates a Proliferative Response by Islam, Md.Shahidul, Morton, Nicholas M., Hansson, Anders, Emilsson, Valur

“…In addition to its interaction at hypothalamic sites to affect feeding and energy expenditure, leptin has been shown to exhibit a proliferative response in…”
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Peripheral metabolic actions of leptin by Cawthorne, Micheal A., Morton, Nicholas M., Pallett, Anna L., Ling Liu, Yong, Emilsson, Valur

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The long non-coding RNA Cerox1 is a post transcriptional regulator of mitochondrial complex I catalytic activity by Sirey, Tamara M, Roberts, Kenny, Haerty, Wilfried, Bedoya-Reina, Oscar, Rogatti-Granados, Sebastian, Tan, Jennifer Y, Li, Nick, Heather, Lisa C, Carter, Roderick N, Cooper, Sarah, Finch, Andrew J, Wills, Jimi, Morton, Nicholas M, Marques, Ana Claudia, Ponting, Chris P

“…To generate energy efficiently, the cell is uniquely challenged to co-ordinate the abundance of electron transport chain protein subunits expressed from both…”
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Hepatic hydrogen sulfide levels are reduced in mouse model of Hutchinson-Gilford progeria syndrome by Wilkie, Stephen E, Marcu, Diana E, Carter, Roderick N, Morton, Nicholas M, Gonzalo, Susana, Selman, Colin

“…Hutchinson-Gilford progeria syndrome (HGPS) is a rare human disease characterised by accelerated biological ageing. Current treatments are limited, and most…”
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Novel Adipose Tissue–Mediated Resistance to Diet-Induced Visceral Obesity in 11β-Hydroxysteroid Dehydrogenase Type 1–Deficient Mice by MORTON, Nicholas M, PATERSON, Janice M, MASUZAKI, Hiroaki, HOLMES, Megan C, STAELS, Bart, FIEVET, Catherine, WALKER, Brian R, FLIER, Jeffrey S, MULLINS, John J, SECKL, Jonathan R

“…Novel Adipose Tissue–Mediated Resistance to Diet-Induced Visceral Obesity in 11β-Hydroxysteroid Dehydrogenase Type 1–Deficient Mice Nicholas M. Morton 1 ,…”
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