Search Results - "Morton, Howard E"

Development of a Catalytic Enantioselective Conjugate Addition of 1,3-Dicarbonyl Compounds to Nitroalkenes for the Synthesis of Endothelin-A Antagonist ABT-546. Scope, Mechanism, and Further Application to the Synthesis of the Antidepressant Rolipram by Barnes, David M, Ji, Jianguo, Fickes, Michael G, Fitzgerald, Michael A, King, Steven A, Morton, Howard E, Plagge, Frederick A, Preskill, Margo, Wagaw, Seble H, Wittenberger, Steven J, Zhang, Ji

“…The enantioselective synthesis of endothelin-A antagonist ABT-546 has been accomplished via the discovery and development of a highly selective catalytic…”
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Catalytic Enantioselective Conjugate Addition of 1,3-Dicarbonyl Compounds to Nitroalkenes by Ji, Jianguo, Barnes, David M, Zhang, Ji, King, Steven A, Wittenberger, Steven J, Morton, Howard E

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Preclinical development of an oral anti- Wolbachia macrolide drug for the treatment of lymphatic filariasis and onchocerciasis by Taylor, Mark J, von Geldern, Thomas W, Ford, Louise, Hübner, Marc P, Marsh, Kennan, Johnston, Kelly L, Sjoberg, Hanna T, Specht, Sabine, Pionnier, Nicolas, Tyrer, Hayley E, Clare, Rachel H, Cook, Darren A N, Murphy, Emma, Steven, Andrew, Archer, John, Bloemker, Dominique, Lenz, Franziska, Koschel, Marianne, Ehrens, Alexandra, Metuge, Haelly M, Chunda, Valerinne C, Ndongmo Chounna, Patrick W, Njouendou, Abdel J, Fombad, Fanny F, Carr, Robert, Morton, Howard E, Aljayyoussi, Ghaith, Hoerauf, Achim, Wanji, Samuel, Kempf, Dale J, Turner, Joseph D, Ward, Stephen A

“…There is an urgent global need for a safe macrofilaricide drug to accelerate elimination of the neglected tropical diseases onchocerciasis and lymphatic…”
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A Practical and Scaleable Synthesis of A-224817.0, a Novel Nonsteroidal Ligand for the Glucocorticoid Receptor by Ku, Yi-Yin, Grieme, Tim, Raje, Prasad, Sharma, Padam, Morton, Howard E, Rozema, Mike, King, Steve A

“…A practical and scaleable synthesis of a novel nonsteroidal ligand for the glucocorticoid receptor A-224817.0 1A is described. The synthesis proceeds in seven…”
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Discovery of ABBV-4083, a novel analog of Tylosin A that has potent anti-Wolbachia and anti-filarial activity by von Geldern, Thomas W, Morton, Howard E, Clark, Rick F, Brown, Brian S, Johnston, Kelly L, Ford, Louise, Specht, Sabine, Carr, Robert A, Stolarik, Deanne F, Ma, Junli, Rieser, Matthew J, Struever, Dominique, Frohberger, Stefan J, Koschel, Marianne, Ehrens, Alexandra, Turner, Joseph D, Hübner, Marc P, Hoerauf, Achim, Taylor, Mark J, Ward, Stephen A, Marsh, Kennan, Kempf, Dale J

“…There is a significant need for improved treatments for onchocerciasis and lymphatic filariasis, diseases caused by filarial worm infection. In particular, an…”
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Synthesis of Novel GABA Uptake Inhibitors. 3. Diaryloxime and Diarylvinyl Ether Derivatives of Nipecotic Acid and Guvacine as Anticonvulsant Agents by Knutsen, Lars J. S, Andersen, Knud Erik, Lau, Jesper, Lundt, Behrend F, Henry, Rodger F, Morton, Howard E, Nærum, Lars, Petersen, Hans, Stephensen, Henrik, Suzdak, Peter D, Swedberg, Michael D. B, Thomsen, Christian, Sørensen, Per O

“…(3R)-1-[4,4-bis(3-methyl-2-thienyl)-3-butenyl]-3-piperidinecarboxylic acid 1 (tiagabine, Gabitril) is a potent and selective γ-aminobutyric acid (GABA) uptake…”
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An Efficient Multikilogram Synthesis of ABT-963:  A Selective COX-2 Inhibitor by Kerdesky, Francis A. J, Leanna, M. Robert, Zhang, Ji, Li, Wenke, Lallaman, John E, Ji, Jianguo, Morton, Howard E

“…An efficient chemical process for the multikilogram synthesis of ABT-963 (3) is described. The potent and selective COX-2 inhibitor was prepared in four steps…”
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Asymmetric Synthesis of A-240610.0 via a New Atropselective Approach for Axially Chiral Biaryls with Chirality Transfer by Ku, Yi-Yin, Grieme, Tim, Raje, Prasad, Sharma, Padam, King, Steve A, Morton, Howard E

“…A new approach for atropselective preparation of axially chiral biaryl was developed. This process proceeded through a chirality transfer from a stereogenic…”
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Symmetrical alkoxysilyl ethers. A new class of alcohol-protecting groups. Preparation of tert-butoxydiphenylsilyl ethers by Gillard, John W, Fortin, Rejean, Morton, Howard E, Yoakim, Christiane, Quesnelle, Claude A, Daignault, Sylvain, Guindon, Yvan

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Efficient Route to 1-Dimethylsulfamoyl-4-iodoimidazole, Isomerisation of 1-Dimethylsulfamoyl-5-iodoimidazole to 1-Dimethylsulfamoyl-4-iodoimidazole by H. Premchandran, Ramiya, Bhagavatula, Lakshmi, J. Plata, Daniel, A. King, Steven, E. Morton, Howard

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An Efficient Synthesis of the Taxane-Derived Anticancer Agent ABT-271 by DeMattei, John A., Leanna, M. Robert, Li, Wenke, Nichols, Paul J., Rasmussen, Michael W., Morton, Howard E.

“…ABT-271, 1, has been identified as a promising anticancer agent. ABT-271 is a novel taxane possessing a C9-(R)-hydroxyl group as opposed to a C9-ketone which…”
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Efficient asymmetric synthesis of ABT-594; a potent, orally effective analgesic by Lynch, John K., Holladay, Mark W., Ryther, Keith B., Bai, Hao, Hsiao, Chi-Nung, Morton, Howard E., Dickman, Daniel A., Arnold, William, King, Steven A.

“…A concise asymmetric synthesis of ( R)-2-chloro-5-(2-azetidinylmethoxy)pyridine (ABT-594) is presented in which the key intermediate t-butoxycarbonyl protected…”
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Synthesis of the C-13 Side Chain Precursors of the 9-Dihydrotaxane Analogue ABT-271 by Leanna, M. Robert, DeMattei, John A, Li, Wenke, Nichols, Paul J, Rasmussen, Michael, Morton, Howard E

“…N-Boc-l-Leucinol was converted to two C-13 side chain precursors of the 9-dihydrotaxane analogue ABT-271. The trans-oxazolidine acid 4 and the cis-Boc-lactam…”
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Synthesis of 2‘-O-Benzoyl-3-keto-6-O-propargyl-11,12-carbamoyl Erythromycin A by Kerdesky, Francis A. J, Premchandran, Ramiya, Wayne, Gregory S, Chang, Sou-Jen, Pease, Jonathan P, Bhagavatula, Lakshmi, Lallaman, John E, Arnold, William H, Morton, Howard E, King, Steven A

“…An efficient and practical synthesis of 2‘-O-benzoyl-3-keto-6-O-propargyl-11,12-carbamoyl erythromycin A (4) is described. The semisynthetic macrolide was…”
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Dimethylboron bromide and diphenylboron bromide: cleavage of acetals and ketals by Guindon, Yvan, Yoakim, Christiane, Morton, Howard E

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Confirmation and prevention of halogen exchange: practical and highly efficient one-pot synthesis of dibromo- and dichloropyridazinones by Zhang, Ji, Morton, Howard E., Ji, Jianguo

“…Commercially available anilines were converted by a two step, one-pot process to the corresponding pyridazinones in good to excellent yields. During the…”
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The enantioselective synthesis of the potent dopamine D1 agonist (1R,3S)-3-(1'-adamantyl)-1-(aminomethyl)-3,4-dihydro-5,6-dihydroxy-1H-2-benzopyran (A77636) by DeNinno, Michael P, Perner, Richard J, Morton, Howard E, DiDomenico, Stanley

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Dimethylboron bromide--interconversion of protecting groups: preparation of MTM [(methylthio)methyl] ethers, O,S-acetals, and cyanomethyl ethers by Morton, Howard E, Guindon, Yvan

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Deoxygenation of sulfoxides with boron bromide reagents by Guindon, Yvan, Atkinson, Joseph G, Morton, Howard E

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beta.-Acylvinyl anion equivalents: preparation of 1-lithio-3-(tert-butyldimethylsiloxy)-1,3-cyclohexadiene and its reaction with electrophiles by Piers, Edward, Morton, Howard E

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