Search Results - "Morton, David A.V."

Investigating the interactions of amino acid components on a mannitol-based spray-dried powder formulation for pulmonary delivery: A design of experiment approach by Sou, Tomás, Orlando, Laurence, McIntosh, Michelle P., Kaminskas, Lisa M., Morton, David A.V.

“…Combining an amino acid and a sugar is a known strategy in the formulation of spray or freeze dried biomolecule powder formulations. The effect of the amino…”
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The role of force control agents in high-dose dry powder inhaler formulations by Begat, Philippe, Morton, David A V, Shur, Jagdeep, Kippax, Paul, Staniforth, John N, Price, Robert

“…The aim of this study was to determine the aerosolisation and aerodynamic properties of model inhalation particles (salbutamol sulphate and budesonide) upon…”
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Effect of mechanical dry particle coating on the improvement of powder flowability for lactose monohydrate: A model cohesive pharmaceutical powder by Zhou, Qi (Tony), Qu, Li, Larson, Ian, Stewart, Peter J., Morton, David A.V.

“…The aim of this study was to evaluate the effect of an intensive dry coating process on the improvement in flow behaviours for fine cohesive lactose powders as…”
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Importance of particle size and shape on the tensile strength distribution and de-agglomeration of cohesive powders by Das, Shyamal C., Behara, Srinivas Ravindra Babu, Morton, David A.V., Larson, Ian, Stewart, Peter J.

“…The purpose of the study was to understand the role of particle size and shape changes in modifying agglomerate strength distribution and de-agglomeration of…”
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The kinetics of cohesive powder de-agglomeration from three inhaler devices by Behara, Srinivas Ravindra Babu, Larson, Ian, Kippax, Paul, Morton, David A.V., Stewart, Peter

“…The purpose of the current investigation is to understand the kinetics of de-agglomeration (kd) of micronised salbutamol sulphate (SS) and lactohale 300…”
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The Influence of Force Control Agents on the Cohesive-Adhesive Balance in Dry Powder Inhaler Formulations by Begat, Philippe, Price, Robert, Harris, Haggis, Morton, David A.V., Staniforth, John N.

“…The aim of the study was to investigate the specific influence of force control agents (FCAs) (leucine, lecithin and magnesium stearate) on the interfacial…”
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Pharmaceutical dry powder blending and scale-up: Maintaining equivalent mixing conditions using a coloured tracer powder by Barling, David, Morton, David A.V., Hapgood, Karen

“…The identification and optimisation of operating conditions and selection of an appropriate mixer for the manufacturing of pharmaceutical dry powders is…”
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Relationship between surface concentration of l-leucine and bulk powder properties in spray dried formulations by Mangal, Sharad, Meiser, Felix, Tan, Geoffrey, Gengenbach, Thomas, Denman, John, Rowles, Matthew R., Larson, Ian, Morton, David A.V.

“…[Display omitted] The amino acid l-leucine has been demonstrated to act as a lubricant and improve the dispersibility of otherwise cohesive fine particles. It…”
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On the Methods to Measure Powder Flow by Tan, Geoffrey, Morton, David A V, Larson, Ian

“…The flow of powders can often play a critical role in the manufacturing of pharmaceutical products. Many of these processes require good, consistent and…”
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Improving aerosolization of drug powders by reducing powder intrinsic cohesion via a mechanical dry coating approach by Zhou, Qi Tony, Qu, Li, Larson, Ian, Stewart, Peter J., Morton, David A.V.

“…The aim of this study was to investigate the effect of coating on the aerosolization of three model micronized powders. Three model powder materials…”
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Investigation of the Changes in Aerosolization Behavior Between the Jet-Milled and Spray-Dried Colistin Powders Through Surface Energy Characterization by Jong, Teresa, Li, Jian, Morton, David A V, Zhou, Qi Tony, Larson, Ian

“…This study aimed to investigate the surface energy factors behind improved aerosolization performance of spray-dried colistin powder formulations compared with…”
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New developments in dry powder pulmonary vaccine delivery by Sou, Tomás, Meeusen, Els N, de Veer, Michael, Morton, David A.V, Kaminskas, Lisa M, McIntosh, Michelle P

“…Pulmonary immunization has gained increased recognition as a means of triggering both a mucosal and systemic immune response without the use of needles. The…”
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Improving powder flow properties of a cohesive lactose monohydrate powder by intensive mechanical dry coating by Zhou, Qi, Armstrong, Brian, Larson, Ian, Stewart, Peter J, Morton, David A V

“…The objective of this study was to improve the cohesive lactose powder flowability. A cohesive lactose monohydrate powder was processed in either a tumbling…”
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Influence of coating material on the flowability and dissolution of dry-coated fine ibuprofen powders by Qu, Li, Zhou, Qi (Tony), Denman, John A., Stewart, Peter J., Hapgood, Karen P., Morton, David A.V.

“…[Display omitted] This study investigates the effects of a variety of coating materials on the flowability and dissolution of dry-coated cohesive ibuprofen…”
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Understanding the influence of powder flowability, fluidization and de-agglomeration characteristics on the aerosolization of pharmaceutical model powders by Zhou, Qi Tony, Armstrong, Brian, Larson, Ian, Stewart, Peter J., Morton, David A.V.

“…The aim of this study was to investigate the influence of the intrinsic inter-particulate cohesion of model pharmaceutical powders on their aerosolization from…”
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Particle Engineering Via Mechanical Dry Coating in the Design of Pharmaceutical Solid Dosage Forms by Qu, Li, Morton, David A V, Zhou, Qi Tony

“…Cohesive powders are problematic in the manufacturing of pharmaceutical solid dosage forms because they exhibit poor flowability, fluidization and…”
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Designing a multi-component spray-dried formulation platform for pulmonary delivery of biopharmaceuticals: The use of polyol, disaccharide, polysaccharide and synthetic polymer to modify solid-state properties for glassy stabilisation by Sou, Tomás, Forbes, Robert T., Gray, Jason, Prankerd, Richard J., Kaminskas, Lisa M., McIntosh, Michelle P., Morton, David A.V.

“…For a dry powder formulation platform to be suitable for pulmonary delivery of potent biopharmaceuticals, e.g., proteins and peptides, it has to be not only…”
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A strategy to evaluate the surface energy of high packing efficiency fine powders via inverse gas chromatography by Tan, Geoffrey, Qu, Li, Morton, David A.V., Larson, Ian

“…The determination of the surface energy of free-flowing fine powders through IGC analysis can be technically challenging. These powders can have high packing…”
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Investigation of the extent of surface coating via mechanofusion with varying additive levels and the influences on bulk powder flow properties by Zhou, Qi (Tony), Qu, Li, Gengenbach, Thomas, Denman, John A., Larson, Ian, Stewart, Peter J., Morton, David A.V.

“…The objective of this study was to investigate if the coating extent created by a mechanofusion process corresponded with observed changes in bulk powder…”
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The cohesive-adhesive balances in dry powder inhaler formulations I: Direct quantification by atomic force microscopy by Begat, Philippe, Morton, David A V, Staniforth, John N, Price, Robert

“…To obtain a quantitative assessment of the cohesive and adhesive force balance within dry powder inhaler formulations. The atomic force microscope (AFM)…”
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