Search Results - "Mortimer, S."

Development and physiological functions of the lymphatic system: insights from human genetic studies of primary lymphedema by Martin-Almedina, Silvia, Mortimer, Peter S., Ostergaard, Pia

“…Primary lymphedema is a long-term (chronic) condition characterized by tissue lymph retention and swelling that can affect any part of the body, although it…”
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Effect of genotype, gender and age on sheep meat quality and a case study illustrating integration of knowledge by Hopkins, D.L., Mortimer, S.I.

“…Subtle breed differences exist for meat quality traits and the Merino does stand out, although many comparisons are confounded by production site or lack of…”
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The classification and diagnostic algorithm for primary lymphatic dysplasia: an update from 2010 to include molecular findings by Connell, FC, Gordon, K, Brice, G, Keeley, V, Jeffery, S, Mortimer, PS, Mansour, S, Ostergaard, P

“…Historically, primary lymphoedema was classified into just three categories depending on the age of onset of swelling; congenital, praecox and tarda…”
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Self-care treatment for lymphoedema of lymphatic filariasis using integrative medicine by Narahari, Saravu R, Aggithaya, Madhur G, Ryan, Terence J, Muralidharan, Kunnathody, Franks, Peter J, Moffatt, Christine, Mortimer, Peter S

“…Lymphatic filariasis (LF) is a neglected tropical disease presenting mainly as lymphoedema (elephantiasis). At present, LF is not effectively treated…”
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Genetic variation in colour stability traits of lamb cuts under two packaging systems by Mortimer, S.I., Jacob, R.H., Kearney, G., Hopkins, D.L., Warner, R.D.

“…Data from samples of longissmus lumborum (LL) and semimembranosus (SM) muscles from 391 lamb carcasses, which had been packaged in overwrap (OW) or high oxygen…”
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Multisubstrate isotope labeling and metagenomic analysis of active soil bacterial communities by Verastegui, Y, Cheng, J, Engel, K, Kolczynski, D, Mortimer, S, Lavigne, J, Montalibet, J, Romantsov, T, Hall, M, McConkey, B J, Rose, D R, Tomashek, J J, Scott, B R, Charles, T C, Neufeld, J D

“…Soil microbial diversity represents the largest global reservoir of novel microorganisms and enzymes. In this study, we coupled functional metagenomics and DNA…”
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EPHB4 kinase-inactivating mutations cause autosomal dominant lymphatic-related hydrops fetalis by Martin-Almedina, Silvia, Martinez-Corral, Ines, Holdhus, Rita, Vicente, Andres, Fotiou, Elisavet, Lin, Shin, Petersen, Kjell, Simpson, Michael A, Hoischen, Alexander, Gilissen, Christian, Jeffery, Heather, Atton, Giles, Karapouliou, Christina, Brice, Glen, Gordon, Kristiana, Wiseman, John W, Wedin, Marianne, Rockson, Stanley G, Jeffery, Steve, Mortimer, Peter S, Snyder, Michael P, Berland, Siren, Mansour, Sahar, Makinen, Taija, Ostergaard, Pia

“…Hydrops fetalis describes fluid accumulation in at least 2 fetal compartments, including abdominal cavities, pleura, and pericardium, or in body tissue. The…”
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Investigation of clinical characteristics and genome associations in the 'UK Lipoedema' cohort by Grigoriadis, Dionysios, Sackey, Ege, Riches, Katie, van Zanten, Malou, Brice, Glen, England, Ruth, Mills, Mike, Dobbins, Sara E, Lee, Li Ling, Jeffery, Steve, Dong, Liang, Savage, David B, Mortimer, Peter S, Keeley, Vaughan, Pittman, Alan, Gordon, Kristiana, Ostergaard, Pia

“…Lipoedema is a chronic adipose tissue disorder mainly affecting women, causing excess subcutaneous fat deposition on the lower limbs with pain and tenderness…”
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Enhancing Soil Organic Matter as a Route to the Ecological Intensification of European Arable Systems by Garratt, M. P. D., Bommarco, R., Kleijn, D., Martin, E., Mortimer, S. R., Redlich, S., Senapathi, D., Steffan-Dewenter, I., Świtek, S., Takács, V., van Gils, S., van der Putten, W. H., Potts, S. G.

“…Soil organic matter (SOM) is declining in most agricultural ecosystems, impacting multiple ecosystem services including erosion and flood prevention, climate…”
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Cairo consensus on the IVF laboratory environment and air quality: report of an expert meeting by Mortimer, D., Cohen, J., Mortimer, S.T., Fawzy, M., McCulloh, D.H., Morbeck, D.E., Pollet-Villard, X., Mansour, R.T., Brison, D.R., Doshi, A., Harper, J.C., Swain, J.E., Gilligan, A.V.

“…This proceedings report presents the outcomes from an international Expert Meeting to establish a consensus on the recommended technical and operational…”
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Case Report: Progressive central conducting lymphatic abnormalities in the RASopathies. Two case reports, including successful treatment by MEK inhibition by Gordon, Kristiana, Moore, Matthew, Van Zanten, Malou, Pearce, Julian, Itkin, Maxim, Madden, Brendan, Ratnam, Lakshmi, Mortimer, Peter S, Nagaraja, Rani, Mansour, Sahar

“…The RASopathies are a group of genetic conditions resulting from mutations within the RAS/mitogen-activated protein kinase (RAS-MAPK) pathway. Lymphatic…”
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Genetic parameters for meat quality traits of Australian lamb meat by Mortimer, S.I., van der Werf, J.H.J., Jacob, R.H., Hopkins, D.L., Pannier, L., Pearce, K.L., Gardner, G.E., Warner, R.D., Geesink, G.H., Hocking Edwards, J.E., Ponnampalam, E.N., Ball, A.J., Gilmour, A.R., Pethick, D.W.

“…Genetic parameters were estimated for a range of meat quality traits recorded on Australian lamb meat. Data were collected from Merino and crossbred progeny of…”
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Genetic parameters for wool traits, live weight, and ultrasound carcass traits in Merino sheep by Mortimer, S I, Hatcher, S, Fogarty, N M, van der Werf, J H J, Brown, D J, Swan, A A, Greeff, J C, Refshauge, G, Edwards, J E Hocking, Gaunt, G M

“…Genetic correlations between 29 wool production and quality traits and live weight and ultrasound fat depth (FAT) and eye muscle depth (EMD) traits were…”
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PSENEN and NCSTN Mutations in Familial Hidradenitis Suppurativa (Acne Inversa) by Pink, Andrew E., Simpson, Michael A., Brice, Glen W., Smith, Catherine H., Desai, Nemesha, Mortimer, Peter S., Barker, Jonathan N.W.N., Trembath, Richard C.

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Mutations in KIF11 Cause Autosomal-Dominant Microcephaly Variably Associated with Congenital Lymphedema and Chorioretinopathy by Ostergaard, Pia, Simpson, Michael A., Mendola, Antonella, Vasudevan, Pradeep, Connell, Fiona C., van Impel, Andreas, Moore, Anthony T., Loeys, Bart L., Ghalamkarpour, Arash, Onoufriadis, Alexandros, Martinez-Corral, Ines, Devery, Sophie, Leroy, Jules G., van Laer, Lut, Singer, Amihood, Bialer, Martin G., McEntagart, Meriel, Quarrell, Oliver, Brice, Glen, Trembath, Richard C., Schulte-Merker, Stefan, Makinen, Taija, Vikkula, Miikka, Mortimer, Peter S., Mansour, Sahar, Jeffery, Steve

“…We have identified KIF11 mutations in individuals with syndromic autosomal-dominant microcephaly associated with lymphedema and/or chorioretinopathy. Initial…”
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Phase II study of ceralasertib (AZD6738) in combination with durvalumab in patients with advanced gastric cancer by Kwon, Minsuk, Kim, Gahyun, Kim, Ryul, Kim, Kyu-Tae, Kim, Seung Tae, Smith, Simon, Mortimer, Peter G S, Hong, Jung Yong, Loembé, Arsene-Bienvenu, Irurzun-Arana, Itziar, Koulai, Loumpiana, Kim, Kyoung-Mee, Kang, Won Ki, Dean, Emma, Park, Woong-Yang, Lee, Jeeyun

“…BackgroundTargeting the DNA damage repair (DDR) pathways is an attractive strategy for boosting cancer immunotherapy. Ceralasertib (AZD6738) is an oral kinase…”
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Analysis of the coding regions of VEGFR3 and VEGFC in Milroy disease and other primary lymphoedemas by Connell, F. C, Ostergaard, P, Carver, C, Brice, G, Williams, N, Mansour, S, Mortimer, P. S, Jeffery, Steve

“…Milroy disease (hereditary lymphoedema type I, MIM 153100) is a congenital onset primary lymphoedema with autosomal dominant inheritance. Mutations in the…”
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A critical review of the physiological importance and analysis of sperm movement in mammals by Mortimer, S T

“…The identification of human sperm hyperactivated motility has potential importance in sperm function tests, as well as in quality control assays and in…”
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A Novel Splice-Site Mutation in VEGFC Is Associated with Congenital Primary Lymphoedema of Gordon by Nadarajah, Noeline, Schulte, Dörte, McConnell, Vivienne, Martin-Almedina, Silvia, Karapouliou, Christina, Mortimer, Peter S, Jeffery, Steve, Schulte-Merker, Stefan, Gordon, Kristiana, Mansour, Sahar, Ostergaard, Pia

“…Lymphedema is characterized by chronic swelling of any body part caused by malfunctioning or obstruction in the lymphatic system. Primary lymphedema is often…”
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Human lymphatic pumping measured in healthy and lymphoedematous arms by lymphatic congestion lymphoscintigraphy by Modi, S., Stanton, A. W. B., Svensson, W. E., Peters, A. M., Mortimer, P. S., Levick, J. R.

“…Axillary surgery for breast cancer partially obstructs lymph outflow from the arm, chronically raising the lymphatic smooth muscle afterload. This may lead to…”
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