Search Results - "Mortensen, D L"

Insulin-Like Growth Factor Binding Protein-1 Induces Insulin Release in the Rat by Mortensen, D. L, Won, W. B, Siu, J, Reifsnyder, D, Gironella, M, Etcheverry, T, Clark, R. G

“…Injections of human insulin-like growth factor binding protein (hIGFBP-1) are reported to induce hyperglycemia in the rat, suggesting that IGFBP-1 acutely…”
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Insulin-like growth factor-1 and growth hormone (GH) have distinct and overlapping anabolic effects in GH-deficient rats by Clark, R G, Mortensen, D L, Carlsson, L M

“…The anabolic activity of recombinant human growth hormone (rhGH) and insulin-like growth factor 1 (rhlGF-1) given either alone or together were studied in two…”
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Recombinant human growth hormone (GH)-binding protein enhances the growth-promoting activity of human GH in the rat by Clark, R G, Mortensen, D L, Carlsson, L M, Spencer, S A, McKay, P, Mulkerrin, M, Moore, J, Cunningham, B C

“…To address the role of the GH-binding protein (GHBP) in GH physiology, two forms of recombinant human GHBP (rhGHBP) were given alone or in combination with…”
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Growth Hormone Secretagogues Stimulate the Hypothalamic-Pituitary-Adrenal Axis and Are Diabetogenic in the Zucker Diabetic Fatty Rat by Clark, R. G., Thomas, G. B., Mortensen, D. L., Won, W. B., Ma, Y. H., Tomlinson, E. E., Fairhall, K. M., Robinson, I. C. A. F.

“…Abstract Besides stimulating GH release, some GH secretagogues also release ACTH and adrenal steroids. Several novel classes of potent GH secretagogues have…”
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Molecular Mimics of Insulin-like Growth Factor 1 (IGF-1) for Inhibiting IGF-1:  IGF-Binding Protein Interactions by Lowman, Henry B, Chen, Yvonne M, Skelton, Nicholas J, Mortensen, Deborah L, Tomlinson, Elizabeth E, Sadick, Michael D, Robinson, Iain C. A. F, Clark, Ross G

“…IGF-1 (insulin-like growth factor 1) is a 70-residue protein hormone which has both metabolic and mitogenic activities mediated through IGF-1 binding to cell…”
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The obese growth hormone (GH)-deficient dwarf rat: body fat responses to patterned delivery of GH and insulin-like growth factor-I by Clark, R G, Mortensen, D L, Carlsson, L M, Carlsson, B, Carmignac, D, Robinson, I C

“…We describe a new animal model of obesity and GH deficiency and report the effects on body fat of administering (GH) and insulin-like growth factor (IGF-I) in…”
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Recombinant human growth hormone (GH)-binding protein enhances the growth-promoting activity of human GH in the rat by Clark, R G, Mortensen, D L, Carlsson, L M, Spencer, S A, McKay, P, Mulkerrin, M, Moore, J, Cunningham, B C

“…To address the role of the GH-binding protein (GHBP) in GH physiology, two forms of recombinant human GHBP (rhGHBP) were given alone or in combination with…”
Get full text

Differential long-term effects of insulin-like growth factor-I (IGF-I) growth hormone (GH), and IGF-I plus GH on body growth and IGF binding proteins in hypophysectomized rats by Fielder, P J, Mortensen, D L, Mallet, P, Carlsson, B, Baxter, R C, Clark, R G

“…The long-term effects of recombinant human insulin-like growth factor-I (rhIGF-I) and GH (rhGH) on body growth and the IGF-I/IGF binding protein…”
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Binding protein-3-selective insulin-like growth factor I variants: engineering, biodistributions, and clearance by Dubaquié, Y, Mortensen, D L, Intintoli, A, Hogue, D A, Nakamura, G, Rancatore, P, Lester, P, Sadick, M D, Filvaroff, E, Fielder, P J, Lowman, H B

“…Insulin-like growth factor I (IGF-I) is a potent anabolic peptide that mediates most of its pleiotropic effects through association with the IGF type I…”
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Growth hormone secretagogues stimulate the hypothalamic-pituitary-adrenal axis and are diabetogenic in the Zucker diabetic fatty rat by Clark, R G, Thomas, G B, Mortensen, D L, Won, W B, Ma, Y H, Tomlinson, E E, Fairhall, K M, Robinson, I C

“…Besides stimulating GH release, some GH secretagogues also release ACTH and adrenal steroids. Several novel classes of potent GH secretagogues have recently…”
Get full text

The obese growth hormone (GH)-deficient dwarf rat: body fat responses to patterned delivery of GH and insulin-like growth factor-I by Clark, R G, Mortensen, D L, Carlsson, L M, Carlsson, B, Carmignac, D, Robinson, I C

“…We describe a new animal model of obesity and GH deficiency and report the effects on body fat of administering (GH) and insulin-like growth factor (IGF-I) in…”
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Growth Hormone Secretagogues: Characterization, Efficacy, and Minimal Bioactive Conformation by McDowell, Robert S., Elias, Kathleen A., Stanley, Mark S., Burdick, Daniel J., Burnier, John P., Chan, Kathryn S., Fairbrother, Wayne J., Hammonds, R. Glenn, Gladys S.Ingle, Jacobsen, Neil E., Mortensen, Deborah L., Rawson, Thomas E., Won, Wesley B., Clark, Ross G., Somers, Todd C.

“…Another class of growth hormone (GH) secretagogues has been discovered by altering the backbone structure of a flexible linear GH-releasing peptide (GHRP). In…”
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Insulin-like growth factor binding protein-1 induces insulin release in the rat by Mortensen, D L, Won, W B, Siu, J, Reifsnyder, D, Gironella, M, Etcheverry, T, Clark, R G

“…Injections of human insulin-like growth factor binding protein (hIGFBP-1) are reported to induce hyperglycemia in the rat, suggesting that IGFBP-1 acutely…”
Get full text

An Effector-Reduced Anti- -Amyloid (A ) Antibody with Unique A  Binding Properties Promotes Neuroprotection and Glial Engulfment of A by Adolfsson, O., Pihlgren, M., Toni, N., Varisco, Y., Buccarello, A. L., Antoniello, K., Lohmann, S., Piorkowska, K., Gafner, V., Atwal, J. K., Maloney, J., Chen, M., Gogineni, A., Weimer, R. M., Mortensen, D. L., Friesenhahn, M., Ho, C., Paul, R., Pfeifer, A., Muhs, A., Watts, R. J.

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Differential long-term effects of insulin-like growth factor-I (IGF-I) growth hormone (GH), and IGF-I plus GH on body growth and IGF binding proteins in hypophysectomized rats by Fielder, P J, Mortensen, D L, Mallet, P, Carlsson, B, Baxter, R C, Clark, R G

“…The long-term effects of recombinant human insulin-like growth factor-I (rhIGF-I) and GH (rhGH) on body growth and the IGF-I/IGF binding protein…”
Get full text

Pharmacokinetics and Pharmacodynamics of Multiple Weekly Subcutaneous Efalizumab Doses in Patients With Plaque Psoriasis by Mortensen, Deborah L., Walicke, Patricia A., Wang, Xiaolin, Kwon, Paul, Kuebler, Peter, Gottlieb, Alice B., Krueger, James G., Leonardi, Craig, Miller, Bruce, Joshi, Amita

“…Efalizumab pharmacokinetics, pharmacodynamics, and efficacy were assessed after subcutaneous administration of 1.0 or 2.0 mg/kg/wk for 12 weeks with 12 weeks…”
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Growth Hormone Secretagogues Stimulate the Hypothalamic-Pituitary-Adrenal Axis and Are Diabetogenic in the Zucker Diabetic Fatty Rat 1 by Clark, R. G., Thomas, G. B., Mortensen, D. L., Won, W. B., Ma, Y. H., Tomlinson, E. E., Fairhall, K. M., Robinson, I. C. A. F.

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Growth Hormone Secretagogues Stimulate the Hypothalamic-Pituitary-Adrenal Axis and Are Diabetogenic in the Zucker Diabetic Fatty Rat1 by Clark, R. G, Thomas, G. B, Mortensen, D. L, Won, W. B, Ma, Y. H, Tomlinson, E. E, Fairhall, K. M, Robinson, I. C. A. F

“…Besides stimulating GH release, some GH secretagogues also release ACTH and adrenal steroids. Several novel classes of potent GH secretagogues have recently…”
Get full text