Search Results - "Morten, Michael J"

The essential elements for the noncovalent association of two DNA ends during NHEJ synapsis by Zhao, Bailin, Watanabe, Go, Morten, Michael J., Reid, Dylan A., Rothenberg, Eli, Lieber, Michael R.

“…One of the most central questions about the repair of a double-strand DNA break (DSB) concerns how the two free DNA ends are brought together — a step called…”
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Conformational and migrational dynamics of slipped-strand DNA three-way junctions containing trinucleotide repeats by Hu, Tianyu, Morten, Michael J., Magennis, Steven W.

“…Expansions of CAG/CTG trinucleotide repeats in DNA are the cause of at least 17 degenerative human disorders, including Huntington’s Disease. Repeat…”
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Single-molecule imaging reveals replication fork coupled formation of G-quadruplex structures hinders local replication stress signaling by Lee, Wei Ting C., Yin, Yandong, Morten, Michael J., Tonzi, Peter, Gwo, Pam Pam, Odermatt, Diana C., Modesti, Mauro, Cantor, Sharon B., Gari, Kerstin, Huang, Tony T., Rothenberg, Eli

“…Guanine-rich DNA sequences occur throughout the human genome and can transiently form G-quadruplex (G4) structures that may obstruct DNA replication, leading…”
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Crowding-Induced Hybridization of Single DNA Hairpins by Baltierra-Jasso, Laura E, Morten, Michael J, Laflör, Linda, Quinn, Steven D, Magennis, Steven W

“…It is clear that a crowded environment influences the structure, dynamics, and interactions of biological molecules, but the complexity of this phenomenon…”
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Structural and functional basis of inositol hexaphosphate stimulation of NHEJ through stabilization of Ku-XLF interaction by Kefala Stavridi, Antonia, Gontier, Amandine, Morin, Vincent, Frit, Philippe, Ropars, Virginie, Barboule, Nadia, Racca, Carine, Jonchhe, Sagun, Morten, Michael J, Andreani, Jessica, Rak, Alexey, Legrand, Pierre, Bourand-Plantefol, Alexa, Hardwick, Steven W, Chirgadze, Dimitri Y, Davey, Paul, De Oliveira, Taiana Maia, Rothenberg, Eli, Britton, Sebastien, Calsou, Patrick, Blundell, Tom L, Varela, Paloma F, Chaplin, Amanda K, Charbonnier, Jean-Baptiste

“…Abstract The classical Non-Homologous End Joining (c-NHEJ) pathway is the predominant process in mammals for repairing endogenous, accidental or programmed DNA…”
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Genome-wide alterations of uracil distribution patterns in human DNA upon chemotherapeutic treatments by Pálinkás, Hajnalka L, Békési, Angéla, Róna, Gergely, Pongor, Lőrinc, Papp, Gábor, Tihanyi, Gergely, Holub, Eszter, Póti, Ádám, Gemma, Carolina, Ali, Simak, Morten, Michael J, Rothenberg, Eli, Pagano, Michele, Szűts, Dávid, Győrffy, Balázs, Vértessy, Beáta G

“…Numerous anti-cancer drugs perturb thymidylate biosynthesis and lead to genomic uracil incorporation contributing to their antiproliferative effect. Still, it…”
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High-affinity RNA binding by a hyperthermophilic single-stranded DNA-binding protein by Morten, Michael J., Gamsjaeger, Roland, Cubeddu, Liza, Kariawasam, Ruvini, Peregrina, Jose, Penedo, J. Carlos, White, Malcolm F.

“…Single-stranded DNA-binding proteins (SSBs), including replication protein A (RPA) in eukaryotes, play a central role in DNA replication, recombination, and…”
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KRAS4A directly regulates hexokinase 1 by Amendola, Caroline R., Mahaffey, James P., Parker, Seth J., Ahearn, Ian M., Chen, Wei-Ching, Zhou, Mo, Court, Helen, Shi, Jie, Mendoza, Sebastian L., Morten, Michael J., Rothenberg, Eli, Gottlieb, Eyal, Wadghiri, Youssef Z., Possemato, Richard, Hubbard, Stevan R., Balmain, Allan, Kimmelman, Alec C., Philips, Mark R.

“…The most frequently mutated oncogene in cancer is KRAS , which uses alternative fourth exons to generate two gene products (KRAS4A and KRAS4B) that differ only…”
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Quantitative super-resolution imaging of pathological aggregates reveals distinct toxicity profiles in different synucleinopathies by Morten, Michael J, Sirvio, Liina, Rupawala, Huzefa, Mee Hayes, Emma, Franco, Aitor, Radulescu, Carola, Ying, Liming, Barnes, Samuel J, Muga, Arturo, Ye, Yu

“…Protein aggregation is a hallmark of major neurodegenerative disorders. Increasing data suggest that smaller aggregates cause higher toxic response than…”
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Guidelines for DNA recombination and repair studies: Mechanistic assays of DNA repair processes by Klein, Hannah L, Ang, Kenny K H, Arkin, Michelle R, Beckwitt, Emily C, Chang, Yi-Hsuan, Fan, Jun, Kwon, Youngho, Morten, Michael J, Mukherjee, Sucheta, Pambos, Oliver J, El Sayyed, Hafez, Thrall, Elizabeth S, Vieira-da-Rocha, João P, Wang, Quan, Wang, Shuang, Yeh, Hsin-Yi, Biteen, Julie S, Chi, Peter, Heyer, Wolf-Dietrich, Kapanidis, Achillefs N, Loparo, Joseph J, Strick, Terence R, Sung, Patrick, Van Houten, Bennett, Niu, Hengyao, Rothenberg, Eli

“…Genomes are constantly in flux, undergoing changes due to recombination, repair and mutagenesis. , many of such changes are studies using reporters for…”
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Monitoring amyloid-β 42 conformational change using a spray-printed graphene electrode by Li, Bing, Zhang, Guohui, Tahirbegi, Islam Bogachan, Morten, Michael J., Tan, Haijie

“…[Display omitted] •Development of highly reproducible spray-printed graphene electrochemical sensors.•Use of spray-printed graphene sensors to monitor…”
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Stacking-induced fluorescence increase reveals allosteric interactions through DNA by Morten, Michael J, Lopez, Sergio G, Steinmark, I Emilie, Rafferty, Aidan, Magennis, Steven W

“…Abstract From gene expression to nanotechnology, understanding and controlling DNA requires a detailed knowledge of its higher order structure and dynamics…”
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Binding dynamics of a monomeric SSB protein to DNA: a single-molecule multi-process approach by Morten, Michael J, Peregrina, Jose R, Figueira-Gonzalez, Maria, Ackermann, Katrin, Bode, Bela E, White, Malcolm F, Penedo, J Carlos

“…Single-stranded DNA binding proteins (SSBs) are ubiquitous across all organisms and are characterized by the presence of an OB…”
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Surface Charge Control of Quantum Dot Blinking by Quinn, Steven D, Rafferty, Aidan, Dick, Emma, Morten, Michael J, Kettles, Fraser J, Knox, Chloe, Murrie, Mark, Magennis, Steven W

“…A characteristic property of colloidal semiconductor nanocrystal quantum dots (QDs) is their emission intermittency. Although a unifying theory of QD…”
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Conformational Heterogeneity in a Fully Complementary DNA Three-Way Junction with a GC-Rich Branchpoint by Toulmin, Anita, Baltierra-Jasso, Laura E, Morten, Michael J, Sabir, Tara, McGlynn, Peter, Schröder, Gunnar F, Smith, Brian O, Magennis, Steven W

“…DNA three-way junctions (3WJs) are branched structures that serve as important biological intermediates and as components in DNA nanostructures. We recently…”
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Sub‐Ensemble Monitoring of DNA Strand Displacement Using Multiparameter Single‐Molecule FRET by Baltierra‐Jasso, Laura E., Morten, Michael J., Magennis, Steven W.

“…Non‐enzymatic DNA strand displacement is an important mechanism in dynamic DNA nanotechnology. Here, we show that the large parameter space that is accessible…”
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Single-Molecule Fluorescence Detection of a Synthetic Heparan Sulfate Disaccharide by Dalton, Charlotte E., Quinn, Steven D., Rafferty, Aidan, Morten, Michael J., Gardiner, John M., Magennis, Steven W.

“…The first single‐molecule fluorescence detection of a structurally‐defined synthetic carbohydrate is reported: a heparan sulfate (HS) disaccharide fragment…”
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Cover Feature: Sub‐Ensemble Monitoring of DNA Strand Displacement Using Multiparameter Single‐Molecule FRET (ChemPhysChem 5/2018) by Baltierra‐Jasso, Laura E., Morten, Michael J., Magennis, Steven W.

“…The Cover Feature illustrates the use of multiparameter single‐molecule fluorescence spectroscopy as a sensitive tool for monitoring strand displacement from…”
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Probing DNA Dynamics: Stacking‐Induced Fluorescence Increase (SIFI) versus FRET by Morten, Michael J., Steinmark, I. Emilie, Magennis, Steven W.

“…Stacking‐induced fluorescence increase (SIFI) was introduced recently as a method to probe DNA structure and dynamics using only a single fluorescent label…”
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Cover Feature: Probing DNA Dynamics: Stacking‐Induced Fluorescence Increase (SIFI) versus FRET (ChemPhotoChem 9/2020) by Morten, Michael J., Steinmark, I. Emilie, Magennis, Steven W.

“…The Cover Feature depicts the fluorescent dye Cy3 stacking in a gap in a DNA double helix. The Cy3 emission can be strongly enhanced upon stacking, which is…”
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